Attenuation of amyotrophic lateral sclerosis via stem cell and extracellular vesicle therapy: An updated review
Gavin Lockard,
Jonah Gordon,
Samantha Schimmel
et al.
Abstract:Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurological disease characterized by upper and lower motor neuron degeneration. Though typically idiopathic, familial forms of ALS are commonly composed of a superoxide dismutase 1 (SOD1) mutation. Basic science frequently utilizes SOD1 models in vitro and in vivo to replicate ALS conditions. Therapies are sparse; those that exist in the market extend life minimally, thus driving the demand for research to identify novel therapeutics. Transplantation of s… Show more
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