Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite

Zhang, Jinsong; Peng, Dungeng; Lu, Huiqi; Liu, Qingliang

doi:10.1016/j.taap.2007.09.010

Cited by 27 publications

(10 citation statements)

References 35 publications

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“…Enhancement of DNA repair could be a mechanism of chemoprevention and only very few compounds have been yet shown to act by this mechanism [30]. Furthermore, Zhang et al [31] inferred that selenium only enhances DNA repair of normal tissues as a consequence of the selective modulation of selenium on Nrf2 in tumor and normal tissues [32], supporting the SeMet supplementation of cancer patients treated with chemotherapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes

Laffón

Valdiglesias

Pásaro

et al. 2009

Biol Trace Elem Res

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The objective of this work was to evaluate the effects of selenomethionine (SeMet) on the induction, repair, and persistence of DNA damage in human leukocytes challenged with bleomycin (BLM). Comet assay was used to determine DNA strand breaks and hOGG1 for the specific recognition of oxidative damage. Leukocytes were (A) stimulated with phytohemagglutinin, (B) damaged with BLM, and (C) incubated to allow DNA repair. Comet assay was performed after each phase. SeMet (50 microM) was supplemented either during phase A, B, or C, or AB, or ABC. Treatment with SeMet decreased BLM-induced stand breaks when added during phase AB. Results obtained after the repair period indicate that SeMet favors repair of DNA damage especially when applied during phase AB. The comparison between DNA damage before and after repair showed that BLM-induced damage was repaired better in the presence of SeMet. Our results showed antigenotoxic effect of SeMet on BLM-induced DNA and also on repair and persistence of this damage when applied before and simultaneously with BLM.

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Section: Discussionmentioning

confidence: 99%

The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes

Laffón

Valdiglesias

Pásaro

et al. 2009

Biol Trace Elem Res

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“…The utilization of 7 as the source of selenium within the dose range required for the moderation of cisplatin toxicity is the same as that of 6 , an important finding as 7 is significantly less toxic than 6 . Thus 7 effectively decreases cisplatin toxicity without disturbing its therapeutic effect on tumours, thereby improving the therapeutic efficacy of cisplatin …”

Section: Anti‐cancer Potential Of Molecular Selenium Compoundsmentioning

confidence: 99%

Anti‐cancer potential of selenium‐ and tellurium‐containing species: opportunities abound!

Seng

Tiekink

2012

Applied Organom Chemis

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An overview highlighting the anti-cancer potential of (bio-essential) selenium-and tellurium-containing species, with an emphasis on biological targets and mechanisms of action, is presented. Studies thus far have focused on selenium(II) compounds (along withto a lesser extentinorganic selenium and selenium nanoparticles) which often successfully exploit the inherent anti-oxidizing ability of selenium. Significantly less work has been conducted in developing anti-cancer tellurium compounds, yet two tellurium(IV) species are proven, clinically, as anti-cancer agents. Given the prevalence of the disease and the accumulated insights into mechanisms of action, the continued development of selenium-and tellurium-containing molecules is an area deserving greater attention.

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“…In the present study, we used the classical H22 ascites tumor-bearing mice model [20,21] to explore the potential synergistic effect of CI SCFE combined with BLM and investigate the underlying mechanism in the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice

Yang

Sun

Liang

et al. 2017

IJMS

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Bleomycin (BLM), a family of anti-tumor drugs, was reported to exhibit severe side effects limiting its usage in clinical treatment. Therefore, finding adjuvants that enhance the anti-tumor effect and reduce the detrimental effect of BLM is a prerequisite. Chrysanthemum indicum, an edible flower, possesses abundant bioactivities; the supercritical-carbon dioxide fluid extract from flowers and buds of C. indicum (CISCFE) have strong anti-inflammatory, anti-oxidant, and lung protective effects. However, the role of CISCFE combined with BLM treatment on tumor-bearing mice remains unclear. The present study aimed to investigate the potential synergistic effect and the underlying mechanism of CISCFE combined with BLM in the treatment of hepatoma 22 (H22) tumor-bearing mice. The results suggested that the oral administration of CISCFE combined with BLM could markedly prolong the life span, attenuate the BLM-induced pulmonary fibrosis, suppress the production of pro-inflammatory cytokines (interleukin-6), tumor necrosis factor-α, activities of myeloperoxidase, and malondiadehyde. Moreover, CISCFE combined with BLM promoted the ascites cell apoptosis, the activities of caspases 3 and 8, and up-regulated the protein expression of p53 and down-regulated the transforming growth factor-β1 by activating the gene expression of miR-29b. Taken together, these results indicated that CISCFE could enhance the anti-cancer activity of BLM and reduce the BLM-induced pulmonary injury in H22 tumor-bearing mice, rendering it as a potential adjuvant drug with chemotherapy after further investigation in the future.

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Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite

Cited by 27 publications

References 35 publications

The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes

The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes

Anti‐cancer potential of selenium‐ and tellurium‐containing species: opportunities abound!

Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice

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