Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis

Cascio, Nella Lo; Saba, Riccardo; Hauser, Marta; Vernal, Ditte Lammers; Al-Jadiri, Aseel; Borenstein, Yehonatan; Sheridan, E. Marcia; Kishimoto, Toshifumi; Armando, Marco; Vicari, Stefano; Nastro, Paolo Fiori; Girardi, Paolo; Gebhardt, Eva; Kane, John M.; Auther, Andrea M.; Carrión, Ricardo; Cornblatt, Barbara A.; Schimmelmann, Benno G.; Schultze‐Lutter, Frauke; Correll, Christoph U.

doi:10.1007/s00787-016-0832-7

Cited by 27 publications

(20 citation statements)

References 56 publications

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“…In our study, most PRSS reported APS at baseline, a larger proportion also presented ANS, while few showed GR plus deterioration, in line with results from other child and adolescent PRS studies (Cascio et al, 2016;Meyer et al, 2005;Spada et al, 2016;Ziermans et al, 2011).…”

Section: Prs Sample Baseline Clinical Characteristicssupporting

confidence: 92%

“…Although the majority of these patients (61.5%) took medication combined with psychological intervention, a considerable number (38.5%) showed pharmacological treatment as the only intervention provided. Recent reports show similar rates of pharmacological treatment (Cascio et al, ; Ziermans et al, ). Some 65.9% of PRSS had at least one DSM‐IV‐TR diagnosis, providing an explanation for the high rates of pharmacological treatment observed.…”

Section: Discussionmentioning

confidence: 70%

“…Although the majority of these patients (61.5%) took medication combined with psychological intervention, a considerable number (38.5%) showed pharmacological treatment as the only intervention provided. Recent reports show similar rates of pharmacological treatment (Cascio et al, 2016;Ziermans et al, 2011). (Schimmelmann, Michel, Martz-Irngartinger, Linder, & Schultze-Lutter, 2015;Schultze-Lutter et al, 2015) could be indicators that UHR criteria need to consider developmental characteristics in this population to improve detection, as other authors have suggested (Schultze-Lutter, Hubl, Schimmelmann, & Michel, 2017).…”

Section: Authors Describe the Earlier Stage Of The Traditional Mcgorrmentioning

confidence: 69%

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Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Dolz

Tor

Serna

et al. 2018

Early Intervention Psych

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Aim: Despite the interest in psychosis risk syndrome (PRS) in children and adolescents, information on the syndrome in this population is scarce.Methods: Prospective naturalistic multi-site study in which 10-to 17-year-old help-seeking subjects who met PRS criteria (positive or negative attenuated symptoms; brief limited intermittent psychotic symptoms; genetic risk or schizotypal personality disorder plus impairment in functioning) were included, along with 45 age and sex-matched healthy controls (HC). All subjects were clinically and functionally assessed. Results: Ninety-one PRS subjects (PRSS) with a mean age of 15.5 AE 1.4 met inclusion criteria (IC). Compared with HC, PRSS presented worse global and academic functioning in the previous year, had experienced more psychiatric and psychological problems, and presented gestational ages outside the normal range. More than 80% of PRSS met ≥2 IC, with 65.9% having one Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision diagnosis, and 61.7% of those having ≥2 diagnoses. Some 49.5% of PRSS had a first-or second-degree family history (FH) of psychosis. Patients with first-and second-degree FH do not differ in their clinical expression.Conclusions: Children and adolescents with PRS are a patient group with a pattern of neurodevelopmental impairment and clinical complexity similar to patients with schizophrenia spectrum disorders, highlighting the importance of assessing these variables in child and adolescent samples. PRSS with first-and second-degree relatives with FH do not present differences in their clinical presentation, suggesting that including these two groups of patients in the genetic risk criteria would enrich knowledge of these criteria. K E Y W O R D Schild and adolescent, clinical high risk for psychosis, psychosis, psychosis risk syndrome

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Section: Prs Sample Baseline Clinical Characteristicssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 70%

“…Although the majority of these patients (61.5%) took medication combined with psychological intervention, a considerable number (38.5%) showed pharmacological treatment as the only intervention provided. Recent reports show similar rates of pharmacological treatment (Cascio et al, 2016;Ziermans et al, 2011). (Schimmelmann, Michel, Martz-Irngartinger, Linder, & Schultze-Lutter, 2015;Schultze-Lutter et al, 2015) could be indicators that UHR criteria need to consider developmental characteristics in this population to improve detection, as other authors have suggested (Schultze-Lutter, Hubl, Schimmelmann, & Michel, 2017).…”

Section: Authors Describe the Earlier Stage Of The Traditional Mcgorrmentioning

confidence: 69%

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Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Dolz

Tor

Serna

et al. 2018

Early Intervention Psych

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“…Results have not been long in coming and we now have good evidence that many mental disorders in children and adolescents are statistically associated with soft and early signs and symptoms. Three papers are dealing with this question in this issue of ECAP [3,4,8], in areas as diverse as ADHD (attention deficit/hyperactivity disorder), psychosis or educational achievement.…”

Section: Introductionmentioning

confidence: 99%

Early detection of child and adolescent mental disorders: some elements of a necessary debate

Falissard

2016

Eur Child Adolesc Psychiatry

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“…This area of conflict is influenced by many different and important factors, among others, by clinicians' uncertainties about the validity of the CHR state in people with highly complex symptom combinations, mostly multiple comorbid psychiatric disorders, additional biological and environmental risk factors, and often frequent childhood adversities. In fact, several recent studies suggest that at least the psychosis CHR criteria may affect a higher proportion of adolescents than adults, with emergence of CHR criteria-based symptomatology at the same time as other mental disorders emerge, complicating the clinical picture [140][141][142]. Furthermore, in a program focusing predominantly on adolescents, younger age of onset of CHR criteria within adolescence was associated with lower conversion rates to psychosis [21].…”

mentioning

confidence: 99%

Pharmacotherapy in Children and Adolescents at Clinical-High Risk for Psychosis and Bipolar Disorder

2016

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This review aims to describe the importance of i) detecting individuals at clinical high-risk for psychosis (schizophrenia) or bipolar disorder, especially in children and adolescents, in order to enable early intervention, and ii) evaluating different intervention strategies, especially pharmacotherapy, during the subsyndromal or "prodromal" stages of these severe and often debilitating disorders. The different approaches regarding the psychotic and bipolar clinical high-risk state are discussed, including reasons and evidence for early (pharmacological) intervention and risks of treatment vs. non-treatment. Only 10 prospective studies of antipsychotics (randomized=4) and 6 prospective studies of non-antipsychotic pharmacologic agents (randomized=3, i. e., omega-3 fatty acids=2, glycine=1) for the psychotic clinical high-risk state and only 4 prospective studies of mood stabilizing medications for the bipolar clinical high-risk state (randomized=2, i. e., lithium=1, valproate=1) were detected. Based on the minimal efficacy data, adverse effect risks, especially in pediatric populations, nonspecific psychopathology, and unknown true risk for the development of either psychosis or bipolar disorder or of chronically disabling symptoms and disability, medication treatment currently remains second choice after psychosocial intervention. Additional research in this area is clearly needed in order to shed more light on the relevance and predictive value of potentially prodromal symptoms, their identification and most appropriate management options.

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Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis

Cited by 27 publications

References 56 publications

Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Early detection of child and adolescent mental disorders: some elements of a necessary debate

Pharmacotherapy in Children and Adolescents at Clinical-High Risk for Psychosis and Bipolar Disorder

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