Attenuated Heart Rate Recovery Following Exercise Testing in Overweight Young Men with Untreated Obstructive Sleep Apnea

Hargens, Trent A.; Guill, Stephen G.; Zedalis, Donald; Gregg, John M.; Nickols‐Richardson, Sharon M.; Herbert, William G.

doi:10.1093/sleep/31.1.104

Cited by 48 publications

(62 citation statements)

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“…In a cohort of morbidly obese patients, Vanhecke et al [7] found that those with OSA had slower HRR than those without. Similarly, Hargens et al [8] demonstrated that overweight young men with OSA had significantly slower HRR than men with similar body mass index but without OSA and men with normal weight and without OSA. Thus, the results of these studies were overall consistent.…”

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confidence: 89%

Heart rate recovery in obstructive sleep apnea: scientific toy or clinical tool?

Maeder

2011

Sleep Breath

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confidence: 89%

Heart rate recovery in obstructive sleep apnea: scientific toy or clinical tool?

Maeder

2011

Sleep Breath

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“…The impact of obstructive sleep apnoea (OSA) on exercise capacity remains unclear, given some studies have shown that this disorder reduces exercise capacity (2-6), whereas others have found no differences in exercise capacity OSA populations (7)(8)(9)(10)(11)(12). factors impact aerobic capacity, as measured by cardiopulmonary exercise testing (CPET).…”

Section: Study Subjectsmentioning

confidence: 99%

“…Furthermore, only one study has included CPET measurements obtained A delayed heart rate (HR) recovery after CPET is considered a predictor of overall mortality (16). Some studies have shown that patients with OSA have an ttenuated HR recovery that is dependent on OSA severity (3,5,11,17). A possible mechanism involves reduced parasympathetic activity, which is observed in patients with OSA during the recovery phase of exercise (11).…”

Section: Study Subjectsmentioning

confidence: 99%

“…Some studies have shown that patients with OSA have an ttenuated HR recovery that is dependent on OSA severity (3,5,11,17). A possible mechanism involves reduced parasympathetic activity, which is observed in patients with OSA during the recovery phase of exercise (11). However, HR recovery in patients with A has primarily been analysed in men because previous studies have included only a small number of women (3,11,17).…”

Section: Study Subjectsmentioning

confidence: 99%

“…A possible mechanism involves reduced parasympathetic activity, which is observed in patients with OSA during the recovery phase of exercise (11). However, HR recovery in patients with A has primarily been analysed in men because previous studies have included only a small number of women (3,11,17). This bias is of particular importance, given HR recovery might be decreased in women compared with men in some populations, such as those fected with heart disease (18).…”

Section: Study Subjectsmentioning

confidence: 99%

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Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

et al. 2017

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INTRODUCTION:To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA). METHODS:Twenty-four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 a index [AHI] <15 h-1) and moderate-to-severe (AHI RESULTS: For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min were found between moderate-to-severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds in the patients with moderate-to-severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation index (r =-0.679, p=.044). CONCLUSION:Exercise capacity is not different bet Nevertheless, patients with moderatethose with milder OSA. Finally, the oxygen desaturation index is related to this slower chron Keywords: Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity. Received March 20, 2017; Accepted May 11, 2017 Copyright: © 2017 Authors. This is an open License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and sourc credited. Editor: Javier Jareño Cite as: Carpio C., Santiago A., Gómez-Mendieta M., Caballero P., Martín capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrom IBJ Plus 2017 1(1):e0004. Funding: The author(s) declared that no grants were involved in supporting this work. To study exercise capacity and heart rate (HR) recovery after peak exercise in morbidly obese female patients with obstructive sleep apnoea (OSA).four morbidly obese female patients (36.17 ± 9.20 years and 45.20 ± 5.41 kg.m diagnosed with OSA underwent cardiopulmonary exercise testing (CPET) for assessment of peak oxygen uptake (V'O2) and heart rate (HR) recovery at 30, 60 and 90 seconds. Comparisons were made between mild (apnoea severe (AHI ≥15 h-1) OSA.For the entire study population, peak V'O2 was 15.58 ± 2.44 ml.min-1.kg-1. No differences in peak V'O2 severe and mild OSA (16.11 ± 2.37 vs. 15.19 ± 2.50 ml.min respectively). HR recovery registered at any time after the peak workload also did not differ between both groups. Nonetheless, the percentage of HR decrease at 90 seconds of recovery time was almost statistically significantly lower severe OSA (p=.073), and it was negatively correlated with the oxygen desaturation Exercise capacity is not different between patients with mild and moderate -to-severe OSA tend to have a slower HR recovery response to exercise than those with milder OSA. Finally, the oxygen desaturation index is related to this slower chronotropic response.Obstructive sleep apnoea, Exercise test, Female, Heart rate, Obesity.May 11, 2017; Published May 23, 2017...

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Heart Rate Recovery and Oxygen Kinetics After Exercise in Obstructive Sleep Apnea Syndrome

Nanas

Sakellariou

Kapsimalakou

et al. 2010

Clinical Cardiology

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Background: Patients who suffer from obstructive sleep apnea (OSA) have a decreased exercise capacity and abnormal autonomic nervous function. However, the kinetics of early oxygen (O 2 ) and heart rate recovery (HRR) have not been described. Materials and Methods:We evaluated 21 men with moderate to severe OSA (mean age: 48 ± 11 yrs, mean apnea-hypopnea index [AHI]: 55 ± 13) and without known heart disease and 10 healthy men matched for age and body mass index (BMI; controls). Men with OSA underwent overnight polysomnography, and both groups underwent symptom-limited incremental cardiopulmonary exercise testing (CPET). We recorded the CPET parameters including peak O 2 uptake (VO 2 p), kinetics of early O 2 recovery by the first degree slope of VO 2 during the first minute (VO 2 /t slope), the time required for a 50% decline of VO 2 p during recovery (T 1/2 ), and early heart rate recovery (HRR = HR at maximal exercise − HR at 1 min of recovery), as well as the chronotropic reserve to exercise ([CR] = [peak HR − resting HR/220 − age − resting HR] × 100). Patients with OSA had a lower VO 2 p (28.7 ± 4.0 vs 34.7 ± 6.2 mL/kg/min), VO 2 /t slope (1.04 ± 0.3 vs 1.4 ± 0.17 mL/kg/min 2 ), and T 1/2 (74 ± 10 vs 56 ± 6 sec) compared to controls (all P < 0.001). In addition, both HRR and CR were lower in the OSA group (22.0 ± 7.0 vs 31.0 ± 6.0 bpm,P:0.003, and 79.0% ± 15% vs 99.0% ± 13.0%, P:0.01, respectively). Conclusions: Patients with OSA demonstrate reduced exercise capacity, delayed oxygen kinetics, and reduced HRR. These data point to abnormal oxygen delivery and/or oxidative function of the peripheral muscles and impaired autonomic nervous activity in OSA patients.

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Attenuated Heart Rate Recovery Following Exercise Testing in Overweight Young Men with Untreated Obstructive Sleep Apnea

Abstract: We found that OSA elicits alterations in the cardiovascular response post exercise, reflected by an attenuated HR recovery. This may indicate an imbalance in the autonomic regulation of HR. Exercise tests may provide utility in risk stratification for those at risk for OSA.

Cited by 48 publications

References 36 publications

Heart rate recovery in obstructive sleep apnea: scientific toy or clinical tool?

Heart rate recovery in obstructive sleep apnea: scientific toy or clinical tool?

Exercise capacity and heart rate recovery response to exercise in morbidly obese female patients with obstructive sleep apnoea syndrome.

Heart Rate Recovery and Oxygen Kinetics After Exercise in Obstructive Sleep Apnea Syndrome

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