“…Currently, it is unclear to what extent activation of the immune system contributes to the peripheral neuropathy observed in our tamoxifen-treated mice. Analysis of several other myelin mutants including Mpz, Pmp22, and Cx32 mice has shown, however, that macrophage activation strongly contributes to the observed peripheral nerve damage, but also paves the way for repair (Carenini et al, 2001;Kobsar et al, 2002Kobsar et al, , 2005Kobsar et al, , 2006; reviewed in Martini et al, 2008). Therefore, it will be interesting in future studies to dissect the contribution of neuroinflammatory processes to the peripheral neuropathy elicited by Sox10 deletion in the adult.…”