Attenuated allergic inflammatory response in the lungs during lactation

Ochoa-Amaya, Julieta E.; Marino, Larissa P.; Tobaruela, Carla N.; Namazu, Lilian Bernadete; Calefi, Atílio Sersun; Margatho, Rafael Oliveira; Gonçalves, Vagner; Queiroz‐Hazarbassanov, Nicolle; Klein, Marianne; Palermo-Neto, João; Oliveira, Ana Paula Ligeiro de; Massoco, Cristina de Oliveira; Felício, Luciano Freitas

doi:10.1016/j.lfs.2016.03.027

Cited by 8 publications

(6 citation statements)

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“…These receptors have a critical role in mediating inflammatory and immune responses, contributing to chronic inflammatory conditions in various disorders such as chronic inflammatory pulmonary disease, asthma, and inflammatory bowel disease [25]. Domperidone-treated animals showed a strong reduction in the intensity of pulmonary allergic inflammation, airway eosinophilia, mucus hypersecretion [13, 14], and P2X7R receptor expression. Consistent with the idea of an effect of prolactin in this circumstance, these hyperprolactinemic animals did not present a statistically significant difference from naive rats.…”

Section: Discussionmentioning

confidence: 99%

“…During the immune response, prolactin stimulates T cells, B cells, natural killer cells, macrophages, neutrophils, CD34-hematopoietic cells, and antigen-presenting dendritic cells [11, 12]. Previously, our group has demonstrated that both domperidone-induced and lactation hyperprolactinemia are capable of attenuating allergic lung inflammation in rats [13, 14] by decreasing leukocyte counts in bronchoalveolar lavage, reducing mucus production, and increasing the expression of IL-4, IL-6, IL-10, TNF-α, and IFN-γ in the lungs [15]. …”

Section: Introductionmentioning

confidence: 99%

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Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Ochoa-Amaya

Queiroz‐Hazarbassanov

Namazu

et al. 2018

Neuroimmunomodulation

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Purpose: We have previously shown that domperidone-induced short-term hyperprolactinemia reduces the lung’s allergic inflammatory response in an ovalbumin antigenic challenge model. Since purinergic receptor P2X7R activity leads to proinflammatory cytokine release and is possibly related to the pathogenesis of allergic respiratory conditions, the present study was designed to investigate a possible involvement of purinergic and prolactin receptors in this phenomenon. Methods: To induce hyperprolactinemia, domperidone was injected intraperitoneally in rats at a dose of 5.1 mg × kg^–1 per day for 5 days. P2X7 expression was evaluated by lung immunohistochemistry while prolactin receptor expression in bronchoalveolar lavage leukocytes was analyzed through flow cytometry. Results: Previous reports demonstrated that rats subjected to short-term hyperprolactinemia exhibited a decrease in leukocyte counts in bronchoalveolar lavage, especially granulocytes. Here, it is revealed that hyperprolactinemia promotes an increased expression of prolactin receptors in granulocytes. Also, increased expression of purinergic P2X7R observed in allergic animals was significantly reduced by hyperprolactinemia. Conclusions: Both purinergic and prolactin receptor expression changes occur during the anti-asthmatic effect of hyperprolactinemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Ochoa-Amaya

Queiroz‐Hazarbassanov

Namazu

et al. 2018

Neuroimmunomodulation

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“…A asma é uma doença inflamatória crônica das vias aéreas, na qual várias células têm papel fundamental tais como os eosinófilos, mastócitos, neutrófilos, células dendríticas e linfócitos T (Boulet et al, 2015;Ochoa -Amaya et al, 2016).…”

Section: Introductionunclassified

Efeito do estresse pré-natal na regulação da inflamação alérgica pulmonar no modelo murino de asma experimental

Gonçalves¹,

Oliveira²,

Kieling³

2016

Orinoquia

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Devido ao seu rápido crescimento, o feto é particularmente vulnerável a insultos e modificações no millieu hormonal. Este fato sugere que situações adversas experimentadas pela mãe grávida podem alterar o desenvolvimento e a saúde da prole, explicado principalmente pela permeabilidade da barreira placentária a diversos hormônios e substâncias. O objetivo deste trabalho foi estudar o efeito do estresse pré-natal na regulação da inflamação alérgica pulmonar, empregando o modelo murino de asma experimental. Para este propósito foram utilizadas camundongas virgens da linhagem Swiss, com 50 dias de idade. Foi empregado o modelo de choque nas patas para promover o estresse pré-natal e o modelo do "metrô de Nova

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“…It has been suggested that in patients with HIV infection, dopaminergic adaptive mechanisms maintain their blood PRL at a high but physiological concentration, which stimulates CD4+ T lymphocyte proliferation and increases viral apoptosis [35] . Also, by enhancing PRL in appropriate amounts, and in even in some cases by inducing short-term mild hyperprolactinemia, intervertebral disc degeneration, graft-versus-host disease, asthma and allergic lung inflammation have been toned down [23] , [31] , [36] , [37] . In this context, it may be noted that mild hyperprolactinemia is normally harmless as many physiological causes like pregnancy, lactation, sleep, and stress [38] raise plasma PRL level.…”

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confidence: 99%

Repurposing prolactin as a promising immunomodulator for the treatment of COVID-19: Are common Antiemetics the wonder drug to fight coronavirus?

Sen¹

2020

Medical Hypotheses

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Prolactin (PRL), the well-known lactogenic hormone, plays a crucial role in immune function given the fact that long term hypoprolactinemia (serum prolactin level below normal) can even lead to death from opportunistic infection. High blood PRL level is known to provide an immunological advantage in many pathological conditions (with some exceptions like autoimmune diseases) and women, because of their higher blood PRL level, get an advantage in this regard. It has been reported that by controlled enhancement of blood PRL level (within the physiological limit and in some cases a little elevated above the normal to induce mild hyperprolactinemia) using dopamine antagonists such immune-stimulatory advantage can led to survival of the patients in many critical conditions. Here it is hypothesized that through controlled augmentation of blood PRL level using dopamine antagonists like domperidone/metoclopramide, which are commonly used drugs for the treatment of nausea and vomiting, both innate and adaptive immunity can be boosted to evade or tone down COVID-19. The hypothesis is strengthened from the fact that at least seven little-understood salient observations in coronavirus patients can apparently be explained by considering the role of enhanced PRL in line with the proposed hypothesis and hence, clinical trials (both therapeutic and prophylactic) on the role of enhanced PRL on the course and outcome of coronavirus patients should be conducted accordingly.

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Attenuated allergic inflammatory response in the lungs during lactation

Abstract: Lactating female rats presented less intense allergic lung inflammation. Our findings suggest that lactation may protect females from asthmatic crises.

Cited by 8 publications

References 46 publications

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs

Efeito do estresse pré-natal na regulação da inflamação alérgica pulmonar no modelo murino de asma experimental

Repurposing prolactin as a promising immunomodulator for the treatment of COVID-19: Are common Antiemetics the wonder drug to fight coronavirus?

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