Attentional networks in neurodegenerative diseases: anatomical and functional evidence from the Attention Network Test

Sarrias-Arrabal, Esteban; Izquierdo-Ayuso, Guillermo; Vázquez‐Marrufo, Manuel

doi:10.1016/j.nrleng.2020.05.022

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…The orienting network depends on the joint regulation of the dorsal and ventral attention networks and is mainly distributed in the bilateral intraparietal sulcus, frontal middle gyrus, frontal eye field, and middle temporal gyrus (Farrant & Uddin, 2015 ). In contrast, the executive control network relies on the anterior cingulate cortex, prefrontal cortex and subcortical structures such as the basal ganglia and cerebellum as well as their projections into the entire cortex (Markett et al, 2022 ; Sarrias-Arrabal et al, 2023 ), mainly in the anterior cingulate gyrus, middle frontal gyrus, superior frontal gyrus, and thalamus (Matsumoto & Tanaka, 2004 ). A longitudinal voxel-based 18 F Fluorodeoxyglucose positron emission tomography (18 F-FDG-PET) study demonstrated persistent hypometabolism of prefrontal lobes in COVID-19 patients with attentional disorders (Kas et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19

Lin,

Gao,

et al. 2024

Brain Imaging and Behavior

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Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly transmissible and pathogenic. Patients with mild cases account for the majority of those infected with coronavirus disease 2019 (COVID-19). Although there is evidence that many patients with COVID-19 have varying degrees of attentional impairment, little is known about how SARS-COV-2 affects attentional function. This study included a high-risk healthcare population divided into groups of healthcare workers (HCWs) with mild COVID-19 (patient group, n = 45) and matched healthy HCWs controls (HC group, n = 42), who completed general neuropsychological background tests and Attention Network Test (ANT), and underwent resting-state functional magnetic resonance imaging (rs-fMRI) using amplitude of low-frequency fluctuation (ALFF) to assess altered brain activity; Selective impairment occurred in orienting and executive control networks, but not in alert network, in the patient group, and widespread cognitive impairment encompassing general attention, memory, and executive dysfunction. Moreover, the patient group had significantly lower ALFF values in the left superior and left middle frontal gyri than the HC group. SARS-COV-2 infection may have led to reduced brain activity in the left superior and left middle frontal gyri, thus impairing attentional orienting and executive control networks, which may explain the development of attentional deficits after COVID-19.

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Section: Discussionmentioning

confidence: 99%

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19

Lin,

Gao,

et al. 2024

Brain Imaging and Behavior

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“…Understanding the anatomical and functional basis of Alzheimer's is one of the great challenges of neuroscience [9]. The three attentional networks (alert, orientation, and executive) described by Posner et al [9] are globally affected due to frontostriatal and frontoparietal degeneration, a decrease in occipital volume, and the loss of gray and white matter [10]. These findings were analyzed with an attention network test (ANT) [9] and other functional tests.…”

Section: Introductionmentioning

confidence: 99%

“…These findings were analyzed with an attention network test (ANT) [9] and other functional tests. Previous data could explain the impairment in cognitive performance and, consequently, the necessity of treatments that stimulate attentional networks [10].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, other types of feedback could be considered based on the therapies' objectives: terminal/delayed feedback, simultaneous/immediate feedback, descriptive feedback, prescriptive feedback, knowledge of the result (KR), and knowledge of the performance (KP), among others. If therapy is applied through video games, the results could improve because, in addition to their working movement and three attentional networks [10], patients enjoy themselves, and the social interactions between generations are increased [18]. Previous studies have already shown the benefits of video game use for balance and risk of falling [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Physical–Cognitive Tasks Including Feedback-Based Technology for Alzheimer’s Disorder in a Randomized Experimental Pilot Study

Benitez-Lugo,

Vazquez-Marrufo,

Pinero-Pinto

et al. 2023

JCM

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Introduction: Alzheimer’s disease causes great changes, with the prefrontal cortex being the most frequently damaged zone; these changes affect physical and cognitive behavior and compromise autonomy. Objective: The objective of this study was to evaluate the effects of physical–cognitive tasks on memory, attention, balance, gait, and risk of falling in Alzheimer’s by using feedback-based technology. Methods: Forty patients with Alzheimer’s were recruited from an Alzheimer’s Association; of these, 15 met the inclusion criteria and were included in the pilot RCT (eight in the control group; seven in the experimental group). Assessment tools: The Cognitive Mini-Examination Scale, Oddball Test and Attention Network, Berg Scale, Tinetti, Timed Up and Go, and Geriatric Deterioration Scale. The experimental group was treated with physical–cognitive tasks by using combined feedback-based technology (visual, acoustic, simultaneous, immediate, and terminal feedback, as well as knowledge of the results and performance) under the supervision of physiotherapists twice per week for 16 thirty-minute sessions. The control group underwent their usual care (pharmacological treatment, mobility exercises, and cognitive stimulation sessions). Result: In the experimental group, the contrast tests showed differences for the re-test (except in attention), with the significative Timed Up and Go test being significant (p = 0.020). The interaction between groups showed significant differences for the experimental group according to the MEC (p = 0.029; d = 0.14) and Tinetti (p = 0.029; d = 0.68). Discussion/Conclusion: Memory, balance, gait, and risk of falling improved in the Alzheimer’s patients through the use of physical–cognitive tasks involving combined feedback-based technology. The effects on attention were inconclusive. The outcomes should be treated with caution due to the sample. This can promote intergenerational bonds, use at home, and adherence to treatment.

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Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

Tabibian,

Azimzadeh,

Shaygannejad

et al. 2023

Sci Rep

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Behavioral aspects and underlying pathology of attention deficit in multiple sclerosis (MS) remain unknown. This study aimed to clarify impairment of attention and its relationship with MS-related fatigue. Thirty-four relapse-remitting MS (RRMS), 35 secondary-progressive MS (SPMS) and 45 healthy controls (HC) were included. Results of psychophysics tasks (attention network test (ANT) and Posner spatial cueing test) and fatigue assessments (visual analogue scale and modified fatigue impact scale (MFIS)) were compared between groups. In ANT, attentional network effects were not different between MS phenotypes and HC. In Posner task, RRMS or SPMS patients did not benefit from valid cues unlike HC. RRMS and SPMS patients had less gain in exogenous trials with 62.5 ms cue-target interval time (CTIT) and endogenous trials with 250 ms CTIT, respectively. Total MFIS was the predictor of gain in 250 ms endogenous blocks and cognitive MFIS predicted orienting attentional effect. Executive attentional effect in RRMS patients with shorter disease duration and orienting attentional effect in longer diagnosed SPMS were correlated with MFIS scores. The pattern of attention deficit in MS differs between phenotypes. Exogenous attention is impaired in RRMS patients while SPMS patients have deficit in endogenous attention. Fatigue trait predicts impairment of endogenous and orienting attention in MS.

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Attentional networks in neurodegenerative diseases: anatomical and functional evidence from the Attention Network Test

Cited by 5 publications

References 47 publications

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19

Analysis of Physical–Cognitive Tasks Including Feedback-Based Technology for Alzheimer’s Disorder in a Randomized Experimental Pilot Study

Patterns of attention deficit in relapsing and progressive phenotypes of multiple sclerosis

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