Attentional network changes in subjective cognitive decline

Esmaeili, Mahdieh; Nejati, Vahid; Shati, Mohsen; Vatan, Reza Fadaei; Chehrehnegar, Negin; Foroughan, Mahshid

doi:10.1007/s40520-021-02005-8

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…In addition, a few longitudinal follow-up and prospective analyses were conducted. The descriptive studies corroborated the existence of a direct relationship between subjective cognitive complaints and the impairment of several executive processes, such as attention, working memory, initiative, cognitive flexibility, inhibition, planning, monitoring, verbal fluency, decision making and goal-directed behaviors [36,39,42,[45][46][47][48]. These functions were directly associated with selfreported complaints from participants but also their informants [34,41,43,44].…”

Section: Resultssupporting

confidence: 63%

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

Webster-Cordero

2022

Geriatrics

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Subjective cognitive complaints correspond to a heterogeneous construct that frequently occurs in the early stages of older adult life. Despite being a common source of worry for middle-aged people, it can be underestimated when clinical and neuropsychological assessments discard any underlying pathological processes. Negative age stereotyping but also self-stereotyping can contribute to doing so. Although its diagnosis is a challenge, its implication as a possible predictor of mild cognitive impairment or dementia increases the interest in its early diagnosis and intervention. The present systematic review analyzes the empirical data on the relationship between these complaints and early executive dysfunction with possible predictive value for preclinical stages of dementia. The sixteen papers obtained from the PubMed and Embase databases were exploratory, cross-sectional and prospective in scope. The studies corroborated the relationship between subjective cognitive complaints and some executive processes, which is noteworthy since many people with subjective executive complaints progress to dementia. The relational studies confirmed that impaired executive performance is associated with CSF biomarkers and reduced cortical volume in specific brain regions. However, the heterogeneity of reports in these studies demands stronger efforts in future research with specific tools applied in clinical and neuropsychological assessments and analyzed under a gender perspective.

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Section: Resultssupporting

confidence: 63%

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

Webster-Cordero

2022

Geriatrics

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“…This association is expected due to the demonstrated associations between rostral-middle LC integrity and objective cognitive performance (Hämmerer et al, 2018; Dahl et al, 2019; Elman et al, 2021) assuming subjective cognitive decline is an indirect measure of actual declines in cognitive function. Subjective cognitive decline may also capture subtle problems in higher order cognitive processing, arousal, and attention when objective testing is normal, as suggested by studies showing disruption of neural networks (Smart et al, 2014; Tu et al, 2018) and lowered alertness to stimuli (Esmaeili et al, 2021). We did not hypothesize relationships between caudal LC region and subjective cognitive decline, although this was investigated to assess regional specificity of effects.…”

Section: Introductionmentioning

confidence: 99%

Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age

Bell

Elman

Beck

et al. 2022

J Int Neuropsychol Soc

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Objectives: Abnormal tau, a hallmark Alzheimer’s disease (AD) pathology, may appear in the locus coeruleus (LC) decades before AD symptom onset. Reports of subjective cognitive decline are also often present prior to formal diagnosis. Yet, the relationship between LC structural integrity and subjective cognitive decline has remained unexplored. Here, we aimed to explore these potential associations. Methods: We examined 381 community-dwelling men (mean age = 67.58; SD = 2.62) in the Vietnam Era Twin Study of Aging who underwent LC-sensitive magnetic resonance imaging and completed the Everyday Cognition scale to measure subjective cognitive decline along with their selected informants. Mixed models examined the associations between rostral-middle and caudal LC integrity and subjective cognitive decline after adjusting for depressive symptoms, physical morbidities, and family. Models also adjusted for current objective cognitive performance and objective cognitive decline to explore attenuation. Results: For participant ratings, lower rostral-middle LC contrast to noise ratio (LCCNR) was associated with significantly greater subjective decline in memory, executive function, and visuospatial abilities. For informant ratings, lower rostral-middle LCCNR was associated with significantly greater subjective decline in memory only. Associations remained after adjusting for current objective cognition and objective cognitive decline in respective domains. Conclusions: Lower rostral-middle LC integrity is associated with greater subjective cognitive decline. Although not explained by objective cognitive performance, such a relationship may explain increased AD risk in people with subjective cognitive decline as the LC is an important neural substrate important for higher order cognitive processing, attention, and arousal and one of the first sites of AD pathology.

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“…There were significant improvements within group: 1) in STM and L in LD group; 2) in STM, A, L, and P in the SCI group; and 3) in TO, ST and STM in the LD group. These findings are important for several reasons: 1) First, STM may be of great relevance given that it declines as people age (Esmaeili et al, 2022). Besides, the existence of an age-dependent relational link in STM could be explained, by less cognitive control (Schmiedek, 2009); 2) Secondly, spoken language impairment can be one of the first signs of cognitive impairment (Beltrami et al, 2018); 3) Third, a significant degree of attention processing problems can be seen in subjective cognitive decline (Esmaeili et al, 2022); and frequently results in deficits in cognitive domains such as memory, TO (Ribeiro et al, 2006) and SO (Quimas et al, 2022) in MCI.…”

Section: Discussionmentioning

confidence: 99%

Effects of cognitive stimulation program on cognition and mood in older adults, stratified by cognitive levels: A randomized controlled trial

Gómez-Soria

Ferreira

Oliván-Blázquez

et al. 2023

Archives of Gerontology and Geriatrics

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Attentional network changes in subjective cognitive decline

Cited by 5 publications

References 30 publications

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age

Effects of cognitive stimulation program on cognition and mood in older adults, stratified by cognitive levels: A randomized controlled trial

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