Attentional functioning is impaired during acute hypoglycaemia in people with Type 1 diabetes

McAulay, Vincent; Deary, Ian J.; Sommerfield, A. J.; Frier, Brian M.

doi:10.1111/j.1464-5491.2005.01795.x

Cited by 30 publications

(22 citation statements)

References 36 publications

(42 reference statements)

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“…Luchsinger et al (2007) have argued that the amnestic type is more typical for diabetes-associated mild cognitive dysfunction because non-amnestic cognitive impairment may be due to other factors, including vascular risk factors. In our study, visual and verbal working memory excluding short-term memory was impaired, indicating that tasks with higher cognitivethat is, executive-demands may be more sensitive for detecting cognitive dysfunction in diabetes (see also Heller &Macdonald, 1996, andMcAulay et al, 2006). Bruehl et al (2007) found elevated plasma cortisol levels and declarative memory deficits in middle-aged individuals with DM2 indicating hypothalamic-pituitaryadrenocortical (HPA) hyperactivity.…”

Section: Discussionmentioning

confidence: 67%

“…Some researchers discovered specific cognitive deficits, including impaired information processing speed and memory (e.g., Gold et al, 2007;McAulay, Deary, Sommerfield, & Frier, 2006;Warren, Zammitt, Deary, & Frier, 2007), while others reported reduced performance particularly in tasks that require higher mental efficiency (e.g., Brands, Bissels, et al, 2007;Watari et al, 2006; for a review, see also Heller & Macdonald, 1996). The presence and severity of cognitive impairments appear to be associated with the duration of illness and glycemic control.…”

mentioning

confidence: 95%

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The Relationship Between Adult Neuropsychological Profiles and Diabetic Patients' Glycemic Control

Zihl¹,

Schaaf²,

Zillmer³

2010

Applied Neuropsychology

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The purpose of this study was to assess, in relation to metabolic control, the cognitive, depressive, and anxiety symptoms among 40 adult patients (age: 18-60 years) with either type 1 (n = 28) or type 2 (n = 12) diabetes mellitus (DM1, DM2). Nineteen healthy subjects matched for age, gender, and education served as the control group. For most cognitive domains, no significant performance differences were found between subjects from the diabetic groups and control subjects. However, diabetes patients demonstrated reduced information processing accuracy along with impaired visual and verbal working memory performance. In addition, psychopathology scores were significantly elevated but did not reach the clinical criteria for depression or anxiety. Overall, there were no significant differences between diabetic subgroups, and no significant correlation was found between cognitive performance, psychopathology scores, and HbA1c values for either subgroup. Thus, patients with DM1 or DM2 may show mild-to-moderate cognitive impairment as well as subtle psychopathological symptoms. While cognitive impairments may be understood in terms of diabetes-associated cognitive dysfunction, psychopathological symptoms may also result from unsuccessful coping with high task demands in everyday life activities. The outcome of the current study underscores the importance of early clinical neuropsychological standardized assessment as well as the diagnosis of cognitive and psychopathological symptoms in adult patients with diabetes.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 95%

The Relationship Between Adult Neuropsychological Profiles and Diabetic Patients' Glycemic Control

Zihl¹,

Schaaf²,

Zillmer³

2010

Applied Neuropsychology

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“…The video required sustained attention for around 10 min, and attention has been shown to be impaired during hypoglycaemia [33,34]. Deterioration of visual information processing may have reduced the subjects' ability to glean information from the video [11,12].…”

Section: Discussionmentioning

confidence: 99%

The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes

et al. 2006

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Aims/hypothesis Global memory performance is impaired during acute hypoglycaemia. This study assessed whether moderate hypoglycaemia disrupts learning and recall in isolation, and utilised a novel test of prospective memory which may better reflect the role of memory in daily life than conventional tests. Subjects and methods Thirty-six subjects with type 1 diabetes participated, 20 with normal hypoglycaemia awareness (NHA) and 16 with impaired hypoglycaemia awareness (IHA). Each underwent a hypoglycaemic clamp with target blood glucose 2.5 mmol/l. Prior to hypoglycaemia, subjects attempted to memorise instructions for a prospective memory task, and recall was assessed during hypoglycaemia. Subjects then completed the learning and immediate recall stages of three conventional memory tasks (word recall, story recall, visual recall) during hypoglycaemia. Euglycaemia was restored and delayed memory for the conventional tasks was tested. The same procedures were completed in euglycaemic control studies (blood glucose 4.5 mmol/l). Results Hypoglycaemia impaired performance significantly on the prospective memory task (p=0.004). Hypoglycaemia also significantly impaired both immediate and delayed recall for the word and story recall tasks (p<0.01 in each case). There was no significant deterioration of performance on the visual memory task. The effect of hypoglycaemia did not differ significantly between subjects with NHA and IHA. Conclusions/interpretation Impaired performance on the prospective memory task during hypoglycaemia demonstrates that recall is disrupted by hypoglycaemia. Impaired performance on the conventional memory tasks demonstrates that learning is also disrupted by hypoglycaemia. Results of the prospective memory task support the relevance of these findings to the everyday lives of people with diabetes.

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“…In adults, the executive function and memory function were both significantly affected by severe hypoglycaemia [53,55,58,[72][73][74][75][76][77][78][79][80].…”

Section: Hypoglycaemiamentioning

confidence: 99%

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

Tonoli¹,

Heyman

Roelands³

et al. 2013

J Diabetes Metab

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Type 1 Diabetes (T1D) can have a significant impact on brain structure and function. This so-called 'diabetesassociated cognitive decline' (DACD) can be attributed to diverse biochemical and neurochemical pathways which are caused by hyperglycaemia, hypoglycaemia, but also by c-peptide and insulin deficiency. Besides the positive effects of exercise on the acute and chronic glycaemic control in T1D patients, a growing number of studies also documented the beneficial influence of exercise on aspects of cognition and performance. Therefore, the purpose of the present narrative review is to discuss the associative aspects between a DACD and its' proposed mechanisms and the potential beneficial effect of exercise on a DACD.

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Attentional functioning is impaired during acute hypoglycaemia in people with Type 1 diabetes

Cited by 30 publications

References 36 publications

The Relationship Between Adult Neuropsychological Profiles and Diabetic Patients' Glycemic Control

The Relationship Between Adult Neuropsychological Profiles and Diabetic Patients' Glycemic Control

The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

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