Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD

McDermott, Timothy J.; Badura-Brack, Amy S.; Becker, Katherine M.; Ryan, Tara J.; Bar‐Haim, Yair; Pine, Daniel S.; Khanna, Maya M.; Heinrichs‐Graham, Elizabeth; Wilson, Tony W.

doi:10.3758/s13415-016-0459-7

Cited by 28 publications

(18 citation statements)

References 51 publications

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“…Each participant completed 128 trials and the task lasted approximately 14 minutes. This same task was previously used in two normative studies and three other clinical studies by our group 21 28 36 37 38 .…”

Section: Methodsmentioning

confidence: 99%

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

Wilson

Proskovec

Heinrichs‐Graham

et al. 2017

Sci Rep

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Impairments in working memory are among the most prevalent features of HIV-associated neurocognitive disorders (HAND), yet their origins are unknown, with some studies arguing that encoding operations are disturbed and others supporting deficits in memory maintenance. The current investigation directly addresses this issue by using a dynamic mapping approach to identify when and where processing in working memory circuits degrades. HIV-infected older adults and a demographically-matched group of uninfected controls performed a verbal working memory task during magnetoencephalography (MEG). Significant oscillatory neural responses were imaged using a beamforming approach to illuminate the spatiotemporal dynamics of neuronal activity. HIV-infected patients were significantly less accurate on the working memory task and their neuronal dynamics indicated that encoding operations were preserved, while memory maintenance processes were abnormal. Specifically, no group differences were detected during the encoding period, yet dysfunction in occipital, fronto-temporal, hippocampal, and cerebellar cortices emerged during memory maintenance. In addition, task performance in the controls covaried with occipital alpha synchronization and activity in right prefrontal cortices. In conclusion, working memory impairments are common and significantly impact the daily functioning and independence of HIV-infected patients. These impairments likely reflect deficits in the maintenance of memory representations, not failures to adequately encode stimuli.

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Section: Methodsmentioning

confidence: 99%

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

Wilson

Proskovec

Heinrichs‐Graham

et al. 2017

Sci Rep

Self Cite

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“…Similarly, patients with PTSD exhibit abnormal oscillatory activity in prefrontal, supramarginal, and interior parietal regions that correlates with working memory deficit. These abnormalities are eliminated after successful attention training to improve working memory, suggesting that this biomarker can help monitor and evaluate treatment effectiveness [84].…”

Section: Human Studies: Identifying Activity-based Biomarkersmentioning

confidence: 99%

Circuit-Based Biomarkers for Mood and Anxiety Disorders

Xia

Kheirbek

2020

Trends in Neurosciences

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Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment. Distributed Neural Circuits Underly Mood and Anxiety Disorders Mood and anxiety disorders disrupt basic functions of individuals' lives, and are among the leading causes of disability [1]. In the USA, it is estimated that at a given timepoint, 10-20% of adults are impacted, and 20-30% of adults will experience a mood or anxiety disorder at some point in their lives (https://www.hcp.med.harvard.edu/ncs). However, most existing treatments are not effective [2,3]; largely due to a lack of clear understanding of disease etiology. The search for effective treatment is further complicated by the fact that mood and anxiety disorders are heterogeneous syndromes with various subtypes, where patients present diverse symptoms even for the same disorder, and often respond differently to the same treatment [4-7]. Highlights Mood and anxiety disorders are complex neural-circuit-based conditions that arise from dysfunctions across multiple cell types, brain regions, and circuits. Recent efforts in identifying circuit-based biomarkers using brain-wide activity patterns have shown promising results in stratifying disorder subtypes and identifying effective treatments for patients with mood and anxiety disorders.

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“…Recent developments in cognitive and neuroscientific interventions that aim to enhance working memory or improve attention control (McDermott et al, 2016), transcranial magnetic stimulation (TMS; Kozel et al, 2019), and new technologies such as virtual reality (Reger et al, 2016) have also shown promise as augmentation interventions.…”

Section: I) Enhancing Existing Treatmentsmentioning

confidence: 99%

Treatment of military-related post-traumatic stress disorder: challenges, innovations, and the way forward

Forbes

Pedlar

Adler

et al. 2019

International Review of Psychiatry

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Attention training improves aberrant neural dynamics during working memory processing in veterans with PTSD

Cited by 28 publications

References 51 publications

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

Circuit-Based Biomarkers for Mood and Anxiety Disorders

Treatment of military-related post-traumatic stress disorder: challenges, innovations, and the way forward

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