Attention to emotion modulates fMRI activity in human right superior temporal sulcus

Narumoto, Jin; Okada, Tomohisa; Sadato, Norihiro; Fukui, Kenji; Yonekura, Yoshiharu

doi:10.1016/s0926-6410(01)00053-2

Cited by 310 publications

(219 citation statements)

References 42 publications

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“…Again, it is possible that N2 corresponds to explicit gaze processing. Explicit facial processing, and thus attention to the face, has been reported to enhance superior temporal sulcus (STS) activation (Hoffman & Haxby, 2000;Narumoto, Okada, Sadato, Fukui, & Yonekura, 2001). Preferential activation of N2 in response to direct gaze was observed only to targets, not to non-targets in the present study, which also suggests the attentional modulation of N2.…”

Section: Discussionsupporting

confidence: 54%

Deviant gaze processing in children with autism: an ERP study

et al. 2005

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Section: Discussionsupporting

confidence: 54%

Deviant gaze processing in children with autism: an ERP study

et al. 2005

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“…Although some studies have shown parietal cortex activation during emotional processing tasks [29,41,48,50,57,59], the present study raises the question of whether attentional demands are driving such effects. Some of the studies showing dorsal activation have used tasks in which the emotional information is task-relevant, which may have consequently introduced a confound between emotional and attentional factors.…”

Section: Dorsal Regionsmentioning

confidence: 57%

Emotion?attention network interactions during a visual oddball task

Fichtenholtz

2004

Cognitive Brain Research

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Emotional and attentional functions are known to be distributed along ventral and dorsal networks in the brain, respectively. However, the interactions between these systems remain to be specified. The present study used event-related functional magnetic resonance imaging (fMRI) to investigate how attentional focus can modulate the neural activity elicited by scenes that vary in emotional content. In a visual oddball task, aversive and neutral scenes were presented intermittently among circles and squares. The squares were frequent standard events, whereas the other novel stimulus categories occurred rarely. One experimental group [N = 10] was instructed to count the circles, whereas another group [N = 12] counted the emotional scenes. A main effect of emotion was found in the amygdala (AMG) and ventral frontotemporal cortices. In these regions, activation was significantly greater for emotional than neutral stimuli but was invariant to attentional focus. A main effect of attentional focus was found in dorsal frontoparietal cortices, whose activity signaled task-relevant target events irrespective of emotional content. The only brain region that was sensitive to both emotion and attentional focus was the anterior cingulate gyrus (ACG). When circles were task-relevant, the ACG responded equally to circle targets and distracting emotional scenes. The ACG response to emotional scenes increased when they were task-relevant, and the response to circles concomitantly decreased. These findings support and extend prominent network theories of emotion -attention interactions that highlight the integrative role played by the anterior cingulate. D

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“…The activation in the frontal regions for the autism group was mostly limited to the right hemisphere, whereas the frontal activation of the control group was bilateral. The autism group did not show activation in the superior and middle gyri of the right posterior temporal lobes, areas associated with processing of social information (e.g., Ojemann et al 1992;Haxby et al 1994;Puce et al 1998;Allison et al 2000;Critchley et al 2000;Narumoto et al 2001;Pelphrey et al 2004), whereas the control group did display activation in these locations. In general, the level of activation in a number of areas increased with working memory load for both groups.…”

Section: Brain Activation Resultsmentioning

confidence: 88%

fMRI Investigation of Working Memory for Faces in Autism: Visual Coding and Underconnectivity with Frontal Areas

et al. 2007

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Brain activation and functional connectivity were investigated in high functioning autism using functional magnetic resonance imaging in an n-back working memory task involving photographic face stimuli. The autism group showed reliably lower activation compared with controls in the inferior left prefrontal area (involved in verbal processing and working memory maintenance) and the right posterior temporal area (associated with theory of mind processing). The participants with autism also showed activation in a somewhat different location in the fusiform area than the control participants. These results suggest that the neural circuitry of the brain for face processing in autism may be analyzing the features of the face more as objects and less in terms of their human significance. The functional connectivity results revealed that the abnormal fusiform activation was embedded in a larger context of smaller and less synchronized networks, particularly indicating lower functional connectivity with frontal areas. In contrast to the underconnectivity with frontal areas, the autism group showed no underconnectivity among posterior cortical regions. These results extend previous findings of abnormal face perception in autism by demonstrating that the abnormalities are embedded in an abnormal cortical network that manages to perform the working memory task proficiently, using a visually oriented, asocial processing style that minimizes reliance on prefrontal areas.

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Attention to emotion modulates fMRI activity in human right superior temporal sulcus

Cited by 310 publications

References 42 publications

Deviant gaze processing in children with autism: an ERP study

Deviant gaze processing in children with autism: an ERP study

Emotion?attention network interactions during a visual oddball task

fMRI Investigation of Working Memory for Faces in Autism: Visual Coding and Underconnectivity with Frontal Areas

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