Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans

Ohara, Shuichi; Crone, Nathan E.; Weiss, Nirit; Lenz, Fred A.

doi:10.1016/j.clinph.2004.02.023

Cited by 101 publications

(87 citation statements)

References 87 publications

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“…This is supposed to index the action of top-down mechanisms over low-level sensory structures, and is in agreement with neuroimaging and intracranial EEG studies demonstrating early activity changes in SI, SII, insula, and anterior cingulate cortex (Hofbauer et al, 2001;Bantick et al, 2002;Ohara et al, 2004). In contrast with this, emotional effects on cortical SEPs were in our experiment much later than attentional effects previously reported.…”

Section: Time Analysis Of Cortical Pain-related Responses: Emotion Vecontrasting

confidence: 56%

Emotional Modulation of Pain: Is It the Sensation or What We Recall?

Godinho¹,

Magnin²,

Frot³

et al. 2006

J. Neurosci.

134

105

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Emotions modulate pain perception, although the mechanisms underlying this phenomenon remain unclear. In this study, we show that intensity reports significantly increased when painful stimuli were concomitant to images showing human pain, whereas pictures with identical emotional values but without somatic content failed to modulate pain. Early somatosensory responses (Ͻ200 ms) remained unmodified by emotions. Conversely, late responses showed a significant enhancement associated with increased pain ratings, localized to the right prefrontal, right temporo-occipital junction, and right temporal pole. In contrast to selective attention, which enhances pain ratings by increasing sensory gain, emotions triggered by seeing other people's pain did not alter processing in SI-SII (primary and second somatosensory areas), but may have biased the transfer to, and the representation of pain in short-term memory buffers (prefrontal), as well as the affective assignment to this representation (temporal pole). Memory encoding and recall, rather than sensory processing, appear to be modulated by empathy with others' physical suffering.

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Section: Time Analysis Of Cortical Pain-related Responses: Emotion Vecontrasting

confidence: 56%

Emotional Modulation of Pain: Is It the Sensation or What We Recall?

Godinho¹,

Magnin²,

Frot³

et al. 2006

J. Neurosci.

134

105

View full text Add to dashboard Cite

show abstract

“…This could be either due to recruitment of small-diameter fibers -which is in accordance with has been seen for pulse stimulation [10,11] but not for sinusoidal stimuli [24] -or discomfort perceived due to the higher intensities. In addition, studies with laser stimuli (i.e., used to assess nociceptive conduction) have shown that after stimulation there is a profile of alpha ERS followed by ERD, at the primary somatosensory, parasylvian and medial frontal cortices [28], which differs from the profile observed in the present study. Nevertheless, to assess whether the nociceptive system was actually involved, it would be needed to evaluate ERD/ERS patterns due to nociceptive stimulation (i.e., temperature) with further stimuli.…”

Section: Discussioncontrasting

confidence: 57%

Untitled

2017

JNSK

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Little is known about the changes in ongoing cortical rhythms due to application of the steady-state sinusoidal electrical stimuli of 3 kHz, although it has been shown to elicit tactile sensations. In addition, it is known that somatosensory stimulation attenuates ongoing alpha rhythm in centroparietal cortex. Thus, the present work aimed to evaluate alpha rhythm alterations in sensorimotor area and sensations perceived with application of 3 kHz sinusoidal stimulus. Sensory perception threshold (ST) was measured in ten healthy volunteers for posterior stimulation in three distinct stimulus intensities (1.1xST, 2xST and 3xST). Cognitive evaluation of perceived sensations was obtained through questionnaires and cortical alpha rhythm blockade profile was evaluated through the classical event-related synchronization/ desynchronization method. Results showed alpha attenuation in the central cortex bilaterally, in the ipsilateral pre-frontal cortex and contralateral parietal cortex during stimulation. Moreover, there was a tendency of bilateral centroparietal alpha rhythm desynchronization increase with stimulus intensity. In conclusion, sinusoidal electrical stimulation may be useful for disease diagnostics and treatment as well as neurofeedback for brain-machine interface (BMI) applications. Patients may benefit from the novel objective method proposed for assessment of tactile perception, mainly, who might not have their cognition preserved (e.g., stroke).

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“…In most reports, LEP are recorded from the scalp, where they are limited by muscle and blink artifacts, by low-pass and spatial filtering at the scalp, skull, and CSF (Cooper et al 1965;Gevins et al 1994;Lenz et al 1998Lenz et al , 2000Ohara et al 2004aOhara et al , 2004bOhara et al , 2004cPfurtscheller and Cooper, 1975;Valeriani et al 2000;Vogel et al 2003;Wang et al 2007), and by large interelectrode distances (Garcia-Larrea et al 2003). We have applied subdural recordings, a technique that brings increased resolution and clarity to the study of human S1 cortical pain mechanisms (Ohara et al 2004b;Scherg 1992).…”

Section: Discussionmentioning

confidence: 99%

Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex

Baumgärtner

Vogel

Ohara

et al. 2011

Journal of Neurophysiology

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The cortical potentials evoked by cutaneous application of a laser stimulus (laser evoked potentials, LEP) often include potentials in the primary somatic sensory cortex (S1), which may be located within the subdivisions of S1 including Brodmann areas 3A, 3B, 1, and 2. The precise location of the LEP generator may clarify the pattern of activation of human S1 by painful stimuli. We now test the hypothesis that the generators of the LEP are located in human Brodmann area 1 or 3A within S1. Local field potential (LFP) source analysis of the LEP was obtained from subdural grids over sensorimotor cortex in two patients undergoing epilepsy surgery. The relationship of LEP dipoles was compared with dipoles for somatic sensory potentials evoked by median nerve stimulation (SEP) and recorded in area 3B (see Baumgärtner U, Vogel H, Ohara S, Treede RD, Lenz FA. J Neurophysiol 104: 3029–3041, 2010). Both patients had an early radial dipole in S1. The LEP dipole was located medial, anterior, and deep to the SEP dipole, which suggests a nociceptive dipole in area 3A. One patient had a later tangential dipole with positivity posterior, which is opposite to the orientation of the SEP dipole in area 3B. The reversal of orientations between modalities is consistent with the cortical surface negative orientation resulting from superficial termination of thalamocortical neurons that receive inputs from the spinothalamic tract. Therefore, the present results suggest that the LEP may result in a radial dipole consistent with a generator in area 3A and a putative later tangential generator in area 3B.

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Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans

Cited by 101 publications

References 87 publications

Emotional Modulation of Pain: Is It the Sensation or What We Recall?

Emotional Modulation of Pain: Is It the Sensation or What We Recall?

Untitled

Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex

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