Attention modulates the gating of primary somatosensory oscillations

Wiesman, Alex I.; Wilson, Tony W.

doi:10.1016/j.neuroimage.2020.116610

Cited by 77 publications

(67 citation statements)

References 64 publications

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“…Based on these analyses, the time-frequency windows that contained statistically significant oscillatory events across all participants and conditions were subjected to a beamforming analysis. A detailed description of this approach is available in a recent paper [90] .…”

Section: Methodsmentioning

confidence: 99%

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

et al. 2020

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Background Despite living a normal lifespan, at least 35% of persons with HIV (PWH) in resource-rich countries develop HIV-associated neurocognitive disorder (HAND). This high prevalence of cognitive decline may reflect accelerated ageing in PWH, but the evidence supporting an altered ageing phenotype in PWH has been mixed. Methods We examined the impact of ageing on the orienting of visual attention in PWH using dynamic functional mapping with magnetoencephalography (MEG) in 173 participants age 22–72 years-old (94 uninfected controls, 51 cognitively-unimpaired PWH, and 28 with HAND). All MEG data were imaged using a state-of-the-art beamforming approach and neural oscillatory responses during attentional orienting were examined for ageing, HIV, and cognitive status effects. Findings All participants responded slower during trials that required attentional reorienting. Our functional mapping results revealed HIV-by-age interactions in left prefrontal theta activity, alpha oscillations in the left parietal, right cuneus, and right frontal eye-fields, and left dorsolateral prefrontal beta activity ( p <.005). Critically, within PWH, we observed a cognitive status-by-age interaction, which revealed that ageing impacted the oscillatory gamma activity serving attentional reorienting differently in cognitively-normal PWH relative to those with HAND in the left temporoparietal, inferior frontal gyrus, and right prefrontal cortices ( p <.005). Interpretation This study provides key evidence supporting altered ageing trajectories across vital attention circuitry in PWH, and further suggests that those with HAND exhibit unique age-related changes in the oscillatory dynamics serving attention function. Additionally, our neural findings suggest that age-related changes in PWH may serve a compensatory function. Funding National Institutes of Health, USA.

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Section: Methodsmentioning

confidence: 99%

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

et al. 2020

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“…During recording, each participant completed a visual-somatosensory oddball paradigm ( Fig. 1 ; Wiesman and Wilson, 2020 ). Stimuli from the two sensory modalities were presented in alternation.…”

Section: Methodsmentioning

confidence: 99%

“…MEG data acquisition, structural coregistration, preprocessing, and sensor-/source-level analyses for both experiments followed a similar pipeline as a number of previous manuscripts from our laboratory ( Kurz et al, 2017 ; Proskovec et al, 2018a ; Spooner et al, 2018 , 2019 ; Wiesman et al, 2017a ; Wiesman and Wilson, 2019 , 2020 ). All recordings took place in a one-layer magnetically-shielded room with active shielding engaged for environmental noise compensation.…”

Section: Methodsmentioning

confidence: 99%

Multi-spectral oscillatory dynamics serving directed and divided attention

et al. 2020

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Attention-related amplification of neural representations of external stimuli has been well documented in the visual domain, however, research concerning the oscillatory dynamics of such directed attention is relatively sparse in humans. Specifically, it is unknown which spectrally-specific neural responses are mainly impacted by the direction and division of attention, as well as whether the effects of attention on these oscillations are spatially disparate. In this study, we use magnetoencephalography and a visual-somatosensory oddball task to investigate the whole-brain oscillatory dynamics of directed ( Experiment 1 ; N = 26) and divided ( Experiment 2 ; N = 34) visual attention. Sensor-level data were transformed into the time-frequency domain and significant responses from baseline were imaged using a frequency-resolved beamformer. We found that multi-spectral cortical oscillations were stronger when attention was sustained in the visual space and that these effects exhibited informative spatial distributions that differed by frequency. More specifically, we found stronger frontal theta (4–8 Hz), frontal and occipital alpha (8–14 Hz), occipital beta (16–22 Hz), and frontal gamma (74–84 Hz) responses when visual attention was sustained than when it was directed away from the visual domain. Similarly, in the divided attention condition, we observed stronger fronto-parietal theta activity and temporo-parietal alpha and beta oscillations when visual attention was sustained toward the visual stimuli than divided between the visual and somatosensory domains. Investigating how attentional gain is implemented in the human brain is essential for better understanding how this process is degraded in disease, and may provide useful targets for future therapies.

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“…All imaging procedures were done with the Brain Electrical Source Analysis (BESA) software (BESA v7.0; Grafelfing, Germany). For additional methodological detail, please see our recent paper (Wiesman & Wilson, 2020).…”

Section: Methodsmentioning

confidence: 99%

The somatosensory cortical activity in individuals with cerebral palsy displays an aberrant developmental trajectory

Trevarrow

Kleinsmith

Taylor

et al. 2020

The Journal of Physiology

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Key points Individuals with cerebral palsy (CP) have a reduced somatosensory cortical response Somatosensory cortical response strength decreases from adolescence to early adulthood Somatosensory cortical responses in youth with CP are similar to adult controls Individuals with CP may have aberrant maturation of the somatosensory system Abstract Numerous studies have documented tactile and proprioceptive deficits in children with cerebral palsy (CP) and linked these with weaker somatosensory cortical activity. However, whether such aberrations in somatosensory processing extend and/or progress into adulthood remains poorly understood. In the current study, we used magnetoencephalography (MEG) to investigate the primary somatosensory responses in a sample of individuals with CP (N = 42; age = 9–28 years) and a cohort of healthy controls (N = 23; age range = 11–23 years). Briefly, transient electrical stimulation was applied to the right tibial nerve, and standardized low‐resolution brain electromagnetic tomography (sLORETA) was used to image the dynamic somatosensory cortical response. We found that the strength of somatosensory cortical activity within the 112–252 ms time window was significantly reduced in the individuals with CP compared with the healthy controls (HC = 286.53 ± 30.51, 95% CI [226.74, 346.32]; CP = 208.30 ± 19.66,CI [169.77, 246.83], P = 0.0126). These results corroborate previous findings of aberrant somatosensory cortical activity in individuals with CP. Our results also suggest that the somatosensory cortical activity tends to become weaker with age, with a similar rate of neurophysiological change in individuals with CP and healthy controls (P = 0.8790). Visualization of regression models fitted to the data imply that youth with CP may have somatosensory cortical activity similar to adult controls. These findings suggest that some individuals with CP exhibit an aberrant developmental trajectory of their somatosensory system.

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Attention modulates the gating of primary somatosensory oscillations

Cited by 77 publications

References 64 publications

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

Multi-spectral oscillatory dynamics serving directed and divided attention

The somatosensory cortical activity in individuals with cerebral palsy displays an aberrant developmental trajectory

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