Attention Modulates Neural Responses to Unpredictable Emotional Faces in Dorsolateral Prefrontal Cortex

Ran, Guangming; Chen, Xu; Zhang, Qi; Ma, Yue; Zhang, Xing

doi:10.3389/fnhum.2016.00332

Cited by 14 publications

(10 citation statements)

References 57 publications

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“…Studies in which the left DLPFC was stimulated have seen diminished engagement with angry faces (De Raedt et al, 2010;Mondino, Thiffault, & Fecteau, 2015;Moulier et al, 2016) associated with increased activity in other areas of the brain, such as the right DLPFC, the left orbitofrontal cortex, and the dorsal anterior cingulate cortex. For fearful faces, however, the literature suggests that there is a general amplified response after inhibitory rTMS to the right DLPFC (Zwanzger et al, 2014), not the left, as the right DLPFC appears to modulate facial fear-specific reactions (Ran et al, 2016). The dorsomedial PFC also seems to be involved in this facial processing circuit, as rTMS seems to worsen performance for angry and fearful faces (Balconi and Bortolotti, 2012).…”

Section: Discussionmentioning

confidence: 99%

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Dumitru

Rocchi

Saini

et al. 2020

Cogn Affect Behav Neurosci

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Repetitive transcranial magnetic stimulation is a potential treatment option for depression, with the newer intermittent theta-burst stimulation (iTBS) protocols providing brief intervention. However, their mechanism of action remains unclear. We investigated the hypothesis that iTBS influences brain circuits involved in emotion processing that are also affected by antidepressants. We predicted that iTBS would lead to changes in performance on emotion-processing tasks. We investigated the effects of intermittent TBS (iTBS) over the left dorsolateral prefrontal cortex (DLPFC) on the processing of emotional information (word recall and categorization, facial emotion recognition, and decision-making) in 28 healthy volunteers by contrasting these effects with those of sham stimulation. Each volunteer received iTBS and sham stimulation in a blinded crossover design and completed the emotion-processing tasks before and after stimulation. Compared to sham stimulation, iTBS increased positive affective processing for word recall, yet had an unexpected effect on facial emotion recognition for happy and sad faces. There was no evidence of an effect on decision-making or word categorization. We found support for our hypothesis that iTBS influences emotion processing, though some changes were not in the expected direction. These findings suggest a possible common mechanism of action between iTBS and antidepressants, and a complex neural circuitry involved in emotion processing that could potentially be tapped into via brain stimulation. Future research should investigate the neural correlates of emotion processing more closely to inform future iTBS protocols.

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Section: Discussionmentioning

confidence: 99%

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Dumitru

Rocchi

Saini

et al. 2020

Cogn Affect Behav Neurosci

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“…A similar result of source localization has been found in previous fMRI studies, which found that the N170 components were located in the right occipital gyrus (e.g., Qiu et al, 2008 ). Although some studies have employed the frequency cue to manipulate the prediction ( Barbalat et al, 2013 ; Chen et al, 2015 ; Ran et al, 2016a , c ), such frequency manipulation is not optimal. It is nice to adopt a contingent probability design in further research as it is more informative than the frequency manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…To test these hypotheses, we adopted a variant of the cue-target paradigm that we employed previously ( Chen et al, 2015 ; Ran et al, 2016c ). An instruction cue was used to manipulate participants’ prediction bias toward the corresponding emotion.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Top-Down Prediction on Emotional Face Processing in Social Anxiety

Ran

Chen

2017

Front. Psychol.

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There is evidence that people with social anxiety show abnormal processing of emotional faces. To investigate the impact of top-down prediction on emotional face processing in social anxiety, brain responses of participants with high and low social anxiety (LSA) were recorded, while they performed a variation of the emotional task, using high temporal resolution event-related potential techniques. Behaviorally, we reported an effect of prediction with higher accuracy for predictable than unpredictable faces. Furthermore, we found that participants with high social anxiety (HSA), but not with LSA, recognized angry faces more accurately than happy faces. For the P100 and P200 components, HSA participants showed enhanced brain activity for angry faces compared to happy faces, suggesting a hypervigilance to angry faces. Importantly, HSA participants exhibited larger N170 amplitudes in the right hemisphere electrodes than LSA participants when they observed unpredictable angry faces, but not when the angry faces were predictable. This probably reflects the top-down prediction improving the deficiency at building a holistic face representation in HSA participants.

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“…Future studies may investigate whether this influence is affected by emotional arousal and/or the interaction between valence and arousal. Finally, it has been shown that the effects of cue uncertainty are modulated by several factors, such as the intolerance of cue uncertainty (Gole et al, 2012), attention (e.g., Ran et al, 2016) and obsessive-compulsive symptoms (e.g., Dieterich et al, 2017). As we did not collect data regarding these issues, it is still unknown whether these factors affected the results of the present study.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Cue Valence Influences the Effects of Cue Uncertainty on ERP Responses to Emotional Events

Lin

Liang

Liu

et al. 2020

Front. Hum. Neurosci.

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Individuals often predict consequences, particularly emotional consequences, according to emotional or non-emotional signals conveyed by environmental cues (i.e., emotional and non-emotional cues, respectively). Some of these cues signify the consequences with certainty (i.e., certain cues), whereas others do not (i.e., uncertain cues). Several event-related potential (ERP) studies regarding non-emotional cues have suggested that the effects of cue uncertainty on attention to emotional events occur in both perception and evaluation processes. However, due to the limitations of previous studies, it is unclear what the effects of cue uncertainty would be in an emotional cue condition. Moreover, it is uncertain whether the effects of cue uncertainty are affected by cue valence (i.e., emotional and non-emotional cues). To address these questions, we asked participants to view cues and then to view emotional (positive or negative) pictures. The cues either did or did not indicate the emotional content of the picture. In the emotional cue condition, happy and fearful faces were used as certain cues indicating upcoming positive and negative pictures, respectively, and neutral faces were used as uncertain cues. In the non-emotional cue condition, scrambled faces outlined in red and blue indicated upcoming positive and negative pictures, respectively, and scrambled faces outlined in green served as uncertain cues. The results showed that for negative pictures, ERP responses in a time range between 60 and 1,000 ms were shifted to a more negative direction in a certain condition than in the uncertain condition when the cues were emotional. However, the effect was the reverse for positive pictures. This effect of cue uncertainty was similar in the non-emotional cue-negative condition. In contrast, there was no effect of cue uncertainty in the non-emotional cue-positive condition. Therefore, the findings indicate that cue uncertainty modulates attention toward emotional events when the events are signified by emotional cues. The findings may also suggest that cue valence modulates the effects of cue uncertainty on attention to emotional events.

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Attention Modulates Neural Responses to Unpredictable Emotional Faces in Dorsolateral Prefrontal Cortex

Cited by 14 publications

References 57 publications

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers

The Impact of Top-Down Prediction on Emotional Face Processing in Social Anxiety

Cue Valence Influences the Effects of Cue Uncertainty on ERP Responses to Emotional Events

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