Attention impairment in temporal lobe epilepsy: A neurophysiological approach via analysis of the P300 wave

Bocquillon, P.; Dujardin, Kathy; Betrouni, Nacim; Phalempin, Valérian; Houdayer, Elise; Bourriez, Jean‐Louis; Derambure, Philippe; Szurhaj, William

doi:10.1002/hbm.20666

Cited by 35 publications

(26 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Latencies in our patients amounted 373 ms for the Fz, and 377 ms for the Cz which is consistent with the statements of other authors [26]. Considering the latency of the P3a potentials (frontally localized) the most frequently quoted value is 220-280 ms, and for the P3b potentials (centroparietally localized) is 310-380 ms [27]. Parameters of the P3 potential primarily reflect basic cognitive domains such as attention and memory.…”

Section: Figure 1 P300 Latencies Of the Control Group And Group Withsupporting

confidence: 78%

P300 event related potential application to cognitive status assessment of the patients with subclinical hypothyroidism

Dejanović¹,

Ivetic²,

Nestorović³

et al. 2015

Praxis Med

View full text Add to dashboard Cite

SUMMARYDisturbances of thyroid function are often accompanied by cognitive and affective disorders. Assessment of cognitive status in the patients with subclinical hypothyroidism represents a possibility for early diagnostics of cognitive impairment and timely introduction of necessary pharmacotherapy treatment. The aim of this study was to quantify whether there are P3 event related potential (ERP) deviations as electrophysiological markers of cognitive activity in patients with subclinical hypothyroidism. P300 potentials were examined in thirty patients with subclinical hypothyroidism and in 30 healthy subjects of the control group. P300 was recorded using the classic auditory oddball paradigm, with 20% of target and 80% of non-target stimuli. The results analysis showed a significantly longer latency P300 and reduced amplitude P300 in subjects with subclinical hypothyroidism compared to euthyroid subjects. There is also a statistically significant negative correlation between the results of a mini mental state examination and the P300 latency at Fz electrode (r= -0.47, p <0.01) and Cz electrode (r= -0.43, p =0.017). P300 ERP is important in the evaluation of patients with subclinical hypothyroidism, due to the sensitivity in the detection cognitive disorders.

show abstract

Section: Figure 1 P300 Latencies Of the Control Group And Group Withsupporting

confidence: 78%

P300 event related potential application to cognitive status assessment of the patients with subclinical hypothyroidism

Dejanović¹,

Ivetic²,

Nestorović³

et al. 2015

Praxis Med

View full text Add to dashboard Cite

show abstract

“…We found significant regional associations of frontal and temporal h FA with performance on tasks of attention, tested using the Digit Span Forward, Continuous Performance Task, and Switching of Attention (digits) tasks, the latter two of which depend on processing speed, and therefore index neural network function. Moreover, the frontal 39–41 and temporal lobes 42 both directly play an important role in attention. The significant association of hFA in the thalamus with emotional PCS is not surprising given susceptibility of the thalamus to mTBI and its role as the brains major relay network, with extensive limbic and prefrontal connectivity 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Changes in Anisotropy Are Associated with Outcomes in Mild Traumatic Brain Injury

Strauß

Kim

Branch

et al. 2016

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

Background and Purpose This prospective longitudinal study identifies early diffusion tensor imaging biomarkers of mild traumatic brain injury that significantly relate to outcomes at 1 year following injury. Materials and Methods DTI was performed on 39 mild traumatic brain injury subjects within 16 days of injury and 40 controls; 26 mild traumatic brain injury subjects returned for follow-up at 1 year. We identified subject-specific regions of abnormally high and low fractional anisotropy, and calculated mean fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity across all white matter voxels brain-wide, and across each of several white matter regions. Assessment of cognitive performance and symptom burden was performed at 1 year. Results Significant associations of brain-wide DTI measures and outcomes included: mean radial diffusivity and mean diffusivity with memory; mean fractional anisotropy, radial diffusivity and mean diffusivity with health-related quality of life. Significant differences in outcomes were found between subjects with and without abnormally high fractional anisotropy for the following white matter regions and outcome measures: left frontal lobe and left temporal lobe with attention at 1 year, left and right cerebelli with somatic post-concussion symptoms at 1 year, and right thalamus with emotional post-concussion symptoms at 1 year. Conclusion Individualized assessment of DTI abnormalities significantly relates to long-term outcomes in mild traumatic brain injury. Abnormally high fractional anisotropy is significantly associated with better outcomes, and might represent an imaging correlate of post-injury compensatory processes.

show abstract

“…There have been a number of investigations in recent years of ERPs in patients with seizure disorders (e.g., Fukai et al, 1990; Zgorzalewicz and Nowak, 2000; Zgorzalewicz, 2006; Chayasirisobhon et al, 2007; Bocquillon et al, 2008). The focus and the methods used in these studies were different from the present one, thereby precluding any direct comparison of results.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the attention impairment in absence epilepsy: Comparison of visual and auditory P300

Duncan

Mirsky

Lovelace

et al. 2009

International Journal of Psychophysiology

View full text Add to dashboard Cite

We report an investigation of P300 measures of information processing in patients with generalized epilepsy of the absence type and those with complex partial epilepsy. Studies have demonstrated that absence patients perform more poorly than complex partial patients on behavioral tests of sustained attention (the Continuous Performance Test, or CPT). Duncan (1988) reported that P300 was significantly reduced in a group of absence patients as compared with healthy controls. The present investigation was undertaken to compare the attention deficit in absence patients to that in complex partial seizure patients. Thus, ERPs were recorded while participants with absence seizure disorder, complex partial seizure disorder, and healthy controls performed auditory and visual versions of the CPT. A significant reduction in the amplitude of P300 on the visual CPT was observed in both groups of seizure patients as compared to controls. In contrast, P300 on the auditory CPT was reduced only in the group with absence seizures. These ERP data support and amplify previous behavioral findings of the impaired capacity of absence patients to mobilize and sustain attentional resources. Auditory sustained attention seems to be more affected by the pathophysiology of absence epilepsy than visual attention. Two possible factors may be involved: (a) There are separate visual and auditory attention systems in the brain, and the latter is more vulnerable than the former (Duncan et al., 2005); and (b) Auditory processing depends on intact mechanisms in the brainstem, which are dysfunctional in patients with absence seizures.

show abstract

Attention impairment in temporal lobe epilepsy: A neurophysiological approach via analysis of the P300 wave

Abstract: This reduction may reflect direct, local cortical dysfunction caused by the epileptic focus or more complex interference between epileptic networks and normal attentional pathways.

Cited by 35 publications

References 60 publications

P300 event related potential application to cognitive status assessment of the patients with subclinical hypothyroidism

P300 event related potential application to cognitive status assessment of the patients with subclinical hypothyroidism

Bidirectional Changes in Anisotropy Are Associated with Outcomes in Mild Traumatic Brain Injury

Assessment of the attention impairment in absence epilepsy: Comparison of visual and auditory P300

Contact Info

Product

Resources

About