Attention-Deficit Hyperactivity Disorder–Associated Impulsive Aggression Treated With Lamotrigine

Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice

“…LTG, beyond the anti-epilepsy role, has also been approved for the maintenance treatment of bipolar disorder by the FDA and may also treat depression and mania. 59 It has shown potential in treating some symptoms in adult attention deficit hyperactivity disorder (ADHD) 60 , 61 , 62 and ASDs, 63 , 64 though its effectiveness is controversial. Some clinical studies reported that LTG could improve attention and social eye contact in autistic children, 64 while another randomized controlled trial reported no effect based on the checklists of diagnostic autistic behavioral criteria.…”

Attention-Deficit/Hyperactivity Disorder–Associated Impulsive Aggression

“…However, it is sometimes still complicated in a small portion of patients. 1 HCV can still recur in some patients. It is crucial to distinguish between relapse and reinfection.…”

“…In a recent article in the Journal, Sablaban et al 1 reported on an interesting case of a 30-year-old woman with adult attention-deficit/hyperactivity disorder (ADHD) and impulsive aggression who responded ultimately favorably to lamotrigine. Few points are noteworthy mentioning.…”