Attention deficit hyperactivity disorder and its association with heavy metals in children from northern Chile

Muñoz, Manuel J.; Rubilar, Paola; Valdés, Macarena; Muñoz-Quezada, María Teresa; Gómez, Andrea; Saavedra, Marta; Iglesias, Verónica

doi:10.1016/j.ijheh.2020.113483

Cited by 23 publications

(7 citation statements)

References 33 publications

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“…A study was conducted on hair samples of children with ADHD and revealed that children's hair lead concentrations ranged from less than one to 11.3 ppm (μg/g) with an observed notably striking relation between ADHD and hair lead levels. Children with a blood lead level ≥ 5 μg/dl doubled the risk of developing ADHD whereas, in inorganic arsenic, a greater risk is observed only when urinary inorganic arsenic concentration is in the highest quintile [21].…”

Section: Discussionmentioning

confidence: 96%

Lead Hair Level Impact on Mongolian Children with Attention Deficit Hyperactivity Disorder

Amgalan¹,

Avirmed²,

Enkhjargal³

et al. 2020

ODEM

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Section: Discussionmentioning

confidence: 96%

Lead Hair Level Impact on Mongolian Children with Attention Deficit Hyperactivity Disorder

Amgalan¹,

Avirmed²,

Enkhjargal³

et al. 2020

ODEM

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“…At the collective level, amphetamines outperformed methylphenidate, atomoxetine, and guanfacine. A greater reaction to amphetamines was shown in 28% of patients, whereas methylphenidate was seen in 16% of patients through crossover R.C.T.s (Muñoz et al, 2020). In case 1, the patient's mom and dad, and coaches stated that he showed substantial progress in his ability to maintain attention and follow directions, as well as in his ability to complete particular school projects and remain focused during his basketball and soccer games.…”

Section: Efficacy and Effectivenessmentioning

confidence: 98%

“…These studies would definitely outperform other methods. Along with these therapies, medication (Muñoz et al, 2020) is an important part of treating ADHD (Muñoz et al, 2020). Several meta-analyses, such as the National Institute of Excellence's, have shown the effectiveness and tolerance of stimulant medication.…”

Section: Treatmentmentioning

confidence: 99%

Case Study on ADHD with Supportive Literature

2024

PSSRP

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“…La acumulación de metales puede generar distintas enfermedades. El arsénico (As) favorece el desarrollo de enfermedad cardiovascular (Kononenko y Frishman, 2021), así como cáncer de piel, pulmón, vejiga e hígado (Palma-Lara et al, 2020), trastorno por déficit de atención e hiperactividad (Muñoz et al, 2020) y neuropatía periférica (He et al, 2021); mientras que la acumulación de Cr propicia cáncer en pulmón, seno paranasal y cavidad nasal (Deere et al, 2022), dermatitis atípica (Özkaya y Elin-Aslan, 2021), trastorno del espectro autista (Wise et al, 2022) y esquizofrenia (Saghazadeh et al, 2020). La toxicidad del Fe puede generar anemia (Torti y Torti, 2020), cáncer de mama, próstata y riñón (Lal, 2020), Enfermedad de Parkinson (Thomas et al, 2020) y Enfermedad de Alzheimer (Peng et al, 2021).…”

Section: Enfermedades Asociadas a La Intoxicación De Metalesunclassified

Efecto citotóxico de iones metálicos

Hernández-Baltazar,

Rivadeneyra-Domínguez,

Pensado-Guevara

et al. 2024

UVserva

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Los iones metálicos con actividad biológica como el cobalto, cobre, cromo, hierro y magnaneso participan en la nutrición, respiración, mantenimiento y comunicación celular. Otros iones como el arsénico, cadmio, mercurio y plomo, que si bien son importantes para la dinámica de suelos y ecosistemas, no son parte del mantenimiento de la homeostásis celular, por el contrario su acumulación exacerbada en el organismo puede favorecer alteraciones patofisiológicas. En los últimos años, la exposición a iones metálicos tóxicos ha ido en aumento debido a su consumo en alimentos, o por exposición ambiental u ocupacional, favoreciéndo patologías a nivel de sistema respiratorio, gastrointestinal, músculo esquelético y sistema nervioso. En órganos de la cavidad abdominal como el hígado y riñón, así como torácicos (pulmón y corazón), los efectos tóxicos son evidentes por la presencia de atrofia celular, edemas e inflamación. A nivel del Sistema Nervioso Central, la neurotoxicidad inducida por iones metálicos se caracteriza por estrés celular exacerbado, neurodegeneración y neuroinflamación. La falla órganica sistémica en combinanción con daño neuronal podría generar disfunción metabólica asociada a desregulación en la síntesis y liberación de neurotransmisores, lo cual podría derivar en alteraciones cognitivas y motoras. En este artículo presentamos una breve revisión del impacto de iones metálicos como el cobalto, cobre, cromo y hierro en la supervivencia celular; y en contraste, el efecto citotóxico del arsénico, cadmio, mercurio y plomo; asimismo, las estrategias usadas para la detección de intoxicación mediante análisis clínico y métodos espectroscópicos o de genómica usados en investigación científica. Cytotoxic effect of metal ions: A brief review Metal ions such as cobalt, copper, chromium, iron and manganese are involved in nutrition, respiration, maintenance and cell communication. However, heavy metal such as arsenic, cadmium, mercury and lead, which are key for soil dynamics, are not necessary to maintain homeostasis. On the contrary, exacerbated levels of heavy metals in cells induce morphophysiological alterations. Till date, exposure to metal ions has been increasing due to their consumption in junk food; due to environmental or occupational exposure favoring respiratory, gastrointestinal, skeletal muscle and neurological diseases. In peritoneal organs such as the liver and kidney, or thoracic organs for example in lung and heart, the toxic effects are evident by the presence of cell atrophy, edema and inflammation. At the central nervous system level, metal ion-induced neurotoxicity is characterized by increased cellular stress, neurodegeneration and neuroinflammation. The combination of systemic organ failure and neuronal damage might lead to metabolic dysfunction and deregulation in the synthesis and release of neurotransmitters, which could further generate cognitive and motor alterations. In this article, we, for the first time present a brief review of the impact of metal ions, such as cobalt, copper, chromium, iron, as key agents for cell survival. In contrast, the cytotoxic effect of arsenic, cadmium, mercury and lead; furthermore, the strategies used for the metal ions-based intoxication detection by clinical analysis or new methods used in scientific research.

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Attention deficit hyperactivity disorder and its association with heavy metals in children from northern Chile

Cited by 23 publications

References 33 publications

Lead Hair Level Impact on Mongolian Children with Attention Deficit Hyperactivity Disorder

Lead Hair Level Impact on Mongolian Children with Attention Deficit Hyperactivity Disorder

Case Study on ADHD with Supportive Literature

Efecto citotóxico de iones metálicos

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