Attention-deficit/hyperactivity disorder (ADHD) association with the DAT1 core promoter −67 T allele

Ohadi, Mina; Shirazi, Elham; Tehranidoosti, Mehdi; Moghimi, Narges; Keikhaee, Mohammad Reza; Ehssani, Sima; Aghajani, Ali; Najmabadi, Hossein

doi:10.1016/j.brainres.2006.05.024

Cited by 20 publications

(16 citation statements)

References 24 publications

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“…A allele frequency of rs2975226 polymorphism was 14.4% and G allele frequency of rs6347 was 11.6% in our study, which are similar to that in other Asian populations (Jeong et al 2004; Shibuya et al 2009). However, A allele frequency of rs2975226 polymorphism is 69.2–76% in Iranian (Keikhaee et al 2005; Khodayari et al 2004; Ohadi et al 2006) and 47% in European Caucasians (Rubie et al 2001; Stober et al 2006). G allele frequency of rs6347 polymorphism is 27–28.6% in European Caucasians (Friedel et al 2007; Lind et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Neither single‐marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese

Yeh

Tao

et al. 2010

Genes Brain and Behavior

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Much evidence suggests that dysfunction of dopamine transporter-mediated dopamine transmission may be involved in the pathophysiology of substance abuse and dependence. The aim of this study was to examine whether the dopamine transporter gene (DAT1; SLC6A3) is associated with the development of heroin dependence (HD) and whether DAT1 influences personality traits in patients with HD. Polymorphisms of DAT1 were analyzed in a case-control study of 1046 Han Chinese (615 patients and 431 controls). All participants were screened using a Chinese version of the modified Schedule of Affective Disorder and SchizophreniaLifetime and all patients met the criteria for HD. Furthermore, a Chinese version of the Tridimensional Personality Questionnaire (TPQ) was used to assess personality traits in the patient group and examine the association between their personality traits and DAT1 polymorphisms. Of the patient group, 271 completed the TPQ. No statistically significant differences in allele or genotype frequencies of all investigated variants between HD patients and controls were observed. In haplotype analyses, four haplotype blocks of DAT1 were not associated with the development of HD. These DAT1 polymorphisms did not influence novelty seeking and harm avoidance scores in HD patients. This study suggests that the DAT1 gene may not contribute to the risk of HD and specific personality traits in HD among the Han Chinese population.

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Section: Discussionmentioning

confidence: 99%

Neither single‐marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese

Yeh

Tao

et al. 2010

Genes Brain and Behavior

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“…A c c e p t e d M a n u s c r i p t region of the DAT1 gene with two further SNP markers [14,21]. In 2006, it was reported that a SNP polymorphism located 67bp upstream to the translation start site was associated with ADHD in a small Iranian population [21].…”

Section: Page 8 Of 11mentioning

confidence: 99%

“…In 2006, it was reported that a SNP polymorphism located 67bp upstream to the translation start site was associated with ADHD in a small Iranian population [21]. Subsequently in 2007…”

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confidence: 99%

Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder

Doyle

Simpson

Park

et al. 2009

Neuroscience Letters

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ABSTRACT:Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multi-centre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1)

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“…Therefore, it is likely that HESR family members recognize a binding site different from that recognized by other bHLH family members. In addition, a functional single nucleotide polymorphism (SNP; −67 A/T) in the promoter was reported to be associated with personality traits, ADHD, and bipolar disorder (Greenwood and Kelsoe, 2003; Ohadi et al, 2006, 2007; Shibuya et al, 2009). This SNP may be a point of interaction with HESR family members.…”

Section: Discussionmentioning

confidence: 99%

DD ArtPix

2011

Developmental Dynamics

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DD ArtPix is a picture gallery of images related to papers published recently in Developmental Dynamics. Most were considered for cover photos, but only one cover photo can be chosen each month. Our authors produce not only excellent science but also excellent art. DD ArtPix provides a sampling of this art for our readers' viewing pleasure. To emphasize their artistic value, images are sometimes manipulated in Photoshop.Images were provided courtesy of authors from the following articles: Dev. Dyn. 240:577-588 (top), 663-673 (bottom).

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Attention-deficit/hyperactivity disorder (ADHD) association with the DAT1 core promoter −67 T allele

Cited by 20 publications

References 24 publications

Neither single‐marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese

Neither single‐marker nor haplotype analyses support an association between the dopamine transporter gene and heroin dependence in Han Chinese

Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder

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