Attention deficit and hyperactivity disorder symptoms respond to gluten-free diet in patients with coeliac disease

Kristensen, Vendel; Valeur, Jørgen; Brackmann, Stephan; Jahnsen, Jørgen; Brunborg, Cathrine; Tveito, Kari

doi:10.1080/00365521.2019.1608467

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…It is worthwhile to reconcile our findings with those of previous studies with CD patients. The mean GSRS score in our study (28.3) was in the range of other patient populations on GFD from different countries (21.0-30.4) [58,59]. Females reported significantly more problems on GSRS compared to males, which is in line with the existing literature suggesting that women with CD experience a greater deterioration in their HRQoL than men [60][61][62][63][64].…”

Section: Discussionsupporting

confidence: 89%

Health utilities and willingness to pay in adult patients with coeliac disease in Hungary

et al. 2023

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Background Coeliac disease (CD) is a life-long food-related disorder with a global prevalence of approximately 1%. Patients with CD often experience reduced health-related quality of life that could improve with a strict adherence to a gluten-free diet (GFD). Objectives To obtain visual analogue scale (VAS), time trade-off (TTO) and willingness-to-pay (WTP) values amongst patients with CD. Methods In 2020–2021, a cross-sectional online survey was conducted amongst 312 adult CD patients in Hungary. Patients completed the Gastrointestinal Symptom Rating Scale (GSRS) and evaluated their current health and three hypothetical health state vignettes defined based on dietary adherence using VAS, conventional 10-year TTO and WTP. Multivariate regressions were used to explore the effect of patients’ demographic and clinical characteristics on utility and WTP values. Results Mean VAS values for current health and ‘CD with strict adherence to GFD’, ‘CD with loose adherence to GFD’ and ‘CD without GFD’ hypothetical health states were 79.69 ± 18.52, 85.36 ± 16.18, 62.44 ± 19.91 and 36.69 ± 25.83, respectively. Corresponding mean TTO utilities were: 0.90 ± 0.19, 0.91 ± 0.20, 0.87 ± 0.23 and 0.76 ± 0.29. Mean annual WTP values for returning to full health were: €845 ± 1077, €648 ± 1002, €862 ± 1135 and €1251 ± 1496. Older age at diagnosis, male sex, more severe gastrointestinal symptoms (GSRS) and having comorbidities were associated with lower VAS and TTO or higher WTP values for current own health (p < 0.05). Conclusion This is the first study to report TTO utilities for CD health states. Strict adherence to the GFD may result in substantial health gains in symptomatic patients. Utilities and WTP results can be used to estimate benefits of GFD in cost-utility and cost–benefit analyses.

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Section: Discussionsupporting

confidence: 89%

Health utilities and willingness to pay in adult patients with coeliac disease in Hungary

et al. 2023

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“…Among 31 newly diagnosed, as many as 26 patients significantly worse assume themselves in the Adult ADHD Self-Report Scale v1.1 Symptoms Checklist (ASRS) survey than the healthy control group. After using a gluten-free diet, their survey results improved significantly, and there was no statistically significant difference between them and between the control group [41].…”

Section: The Influence Of Diet On An Attention-deficit Hyperactivity mentioning

confidence: 89%

Relationship between the diet and psychiatric diseases such as depression, anxiety and attention-deficit hyperactivity disorder (ADHD)

Kozyra¹,

Zimnicki²,

Kaczerska³

et al. 2020

J Educ Health Sport

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Introduction: Some people try to treat psychiatric diseases such as attention-deficit hyperactivity disorder (ADHD), depression and anxiety by practising some diets. But do they even work and have any scientific confirmation? The aim of the study: The aim of this study is to find out the relationship and influence of the diet on psychiatric diseases such as ADHD, depression and anxiety. Material and method: The research of the scientific articles was made on a database of PubMed and Google Scholar. Description of the state of knowledge: The results indicate that the lack of some nutrients such as vitamins B1, B2, B3, B6, B12, C, A, D, E, folic acid, zinc, iodine, selenium, iron, calcium, potassium, phosphorus, magnesium and chrome may increase the risk of having depression symptoms. Unhealthy diet full of trans fats, red meat and lacking of fruit and vegetables may also lead to depression. Similar results were find due to the anxiety level and the diet. When it comes to ADHD, children with this disease had lower level of vitamins B 12 , B 6, D and folic acids. Among the newly diagnosed celiac disease people, the majority showed ADHD symptoms. After the introduction of the gluten-free diet, the symptoms of the disease subsided. Summary: The results show the huge influence of the diet on the diseases such as depression, anxiety and ADHD.

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“…Comparable results between individual scores of IN and HYP in the ADHD population using the ADHD-IV checklist were seen [ 40 ]. Prior to treatment, patients with CeD had significantly higher total ASRS scores, inattention sub-scores, and hyperactivity sub-scores than healthy controls, showing a larger improvement in the inattention versus hyperactivity domain of 4.4 versus 1.9 [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

The Association between ADHD and Celiac Disease in Children

Gaur

2022

Children

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Controversy around the association between celiac disease (CeD) and attention deficit hyperactive disorder (ADHD) was addressed by a systematic review in 2015, ultimately showing no association. Since 2015, there have been several studies showing an association between celiac disease and attention deficit hyperactive disorder. This is an updated systematic review. Background: Most experts agree on the recommendation to not screen as part of the standard of care for ADHD in persons with CeD or vice versa. Simultaneously, they propose that untreated patients with CeD and neurological symptoms such as chronic fatigue, inattention, pain, and headache could be predisposed to ADHD-like behavior, namely inattention (which may be alleviated by following a gluten-free diet). The inattentive subtype of ADHD that encompasses the symptoms of inattention is phenotypically heterogeneous, as it includes the clinical construct of sluggish cognitive tempo (SCT). SCT symptoms overlap with the neurological manifestations of CeD. Methods: A systematic search (PRISMA) of PubMed, Google Scholar, EMBASE, Web of Science, Stanford Lane, SCOPUS, and Ovid was conducted for articles up to 21 February 2022. Of these, 23 studies met the criteria. Results: Out of the 23 studies, 13 showed a positive association between ADHD and CeD. Most studies that showed a positive association had been published in the last five years. Inconsistencies in the results remain due to the heterogeneous methodology used, specifically for ADHD and the outcome questionnaires, as well as a lack of reporting on ADHD subtypes. Conclusion: There is an association between ADHD and celiac disease. The current methodological limitations will be lessened if we examine the subtypes of ADHD.

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Attention deficit and hyperactivity disorder symptoms respond to gluten-free diet in patients with coeliac disease

Cited by 11 publications

References 30 publications

Health utilities and willingness to pay in adult patients with coeliac disease in Hungary

Health utilities and willingness to pay in adult patients with coeliac disease in Hungary

Relationship between the diet and psychiatric diseases such as depression, anxiety and attention-deficit hyperactivity disorder (ADHD)

The Association between ADHD and Celiac Disease in Children

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