Attention and spatial cognition: Neural and anatomical substrates of visual neglect

Lunven, Marine; Bartolomeo, Paolo

doi:10.1016/j.rehab.2016.01.004

Cited by 86 publications

(62 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our cortical thickness and diffusion results suggest an implication of left prefrontal cortex in prism-induced neglect compensation, consistent with the observation that effective PA in neglect is facilitated by TMS-based disinhibition of the left motor cortex (O'Shea et al, 2017). Altogether, these findings fit well with the fronto-parietal organization of attention networks in the primate brain (Lunven & Bartolomeo, 2017) . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 13 Two possibilities can explain the difference in cortical thickness in the contralesional hemisphere.…”

Section: Discussionsupporting

confidence: 90%

Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

Visual neglect is a frequent and disabling consequence of right hemisphere damage. Previous evidence demonstrated a probable role of posterior callosal dysfunction in the chronic persistence of neglect signs. Prism adaptation is a non-invasive and convenient technique to rehabilitate chronic visual neglect, but it is not effective in all patients. Here we hypothesized that prism adaptation improves left neglect by facilitating compensation through the contribution of the left, undamaged hemisphere. To test this hypothesis, we assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Consistent with our hypothesis, patients who benefitted from prism adaptation had a thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere.Additionally, these patients had higher microstructural integrity of the body and genu of the corpus callosum. These callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Thus, prism adaptation may ameliorate signs of left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits for neglect compensation. Highlights:• Visual neglect is a disabling condition resulting from right hemisphere damage • Prism adaptation is a promising therapy, but not all patients respond • We assessed the anatomical predictors of patients' response to prism adaptation • Study of cortical thickness and white matter integrity • Importance of fronto-parietal networks in the left, healthy hemisphere for recovery • Importance of callosal connections in the genu and body for recovery

show abstract

Section: Discussionsupporting

confidence: 90%

Anatomical predictors of successful prism adaptation in chronic visual neglect

Lunven

Rode

Bourlon

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Damage to the superior longitudinal fasciculus is also a key cause of the spatial neglect syndrome (e.g. Shinoura et al, 2009; Ptak & Schnider, 2010; Chechlacz et al, 2012; Lunven & Bartolomeo, 2016). …”

Section: Discussionmentioning

confidence: 99%

Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

et al. 2017

View full text Add to dashboard Cite

Reduced global motion sensitivity, relative to global static form sensitivity, has been found in children with many neurodevelopmental disorders, leading to the “dorsal stream vulnerability” hypothesis (Braddick et al, Neuropsychologia, 2003). Individual differences in typically developing children’s global motion thresholds have been shown to be associated with variations in specific parietal cortical areas (Braddick et al, J Cog Neuro, 2016). Here, in 125 children aged 5–12 years, we relate individual differences in global motion and form coherence thresholds to fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF), a major fiber tract communicating between parietal lobe and anterior cortical areas. We find a positive correlation between FA of the right SLF and individual children’s sensitivity to global motion coherence, while FA of the left SLF shows a negative correlation. Further analysis of parietal cortical area data shows that this is also asymmetrical, showing a stronger association with global motion sensitivity in the left hemisphere. None of these associations hold for an analogous measure of global form sensitivity. We conclude that a complex pattern of structural asymmetry, including the parietal lobe and the superior longitudinal fasciculus, is specifically linked to the development of sensitivity to global visual motion. This pattern suggests that individual differences in motion sensitivity are primarily linked to parietal brain areas interacting with frontal systems in making decisions on integrated motion signals, rather than in the extra-striate visual areas that perform the initial integration. The basis of motion processing deficits in neurodevelopmental disorders may depend on these same structures.

show abstract

“…Diffusion and dissection studies indicate that the IFOF connects some of these same inferior frontal regions with ventral occipital areas [Forkel et al, ], implicating relevance in interpretation of facial affect and emotional valuation of visual stimuli [Philippi, Mehta, Grabowski, Adolphs, & Rudrauf, ; Unger et al, ]. While the left SLF has a prominent role in language function [Catani, Jones, & Ffytche, ; Breier, Hasan, Zhang, Men, & Papanicolaou, ; Caverzasi et al, ], the larger group differences ( d > 0.4) occurred in the right hemisphere where SLF may primarily support spatial attention [Gitelman et al, ; Mapstone et al, ; Lunven & Bartolomeo, ] and aspects of communication such as prosody, gesture, and facial expression [Ahern et al, ; Dara, Bang, Gottesman, & Hillis, ; Sammler, Grosbras, Anwander, Bestelmeyer, & Belin, ], which may be impaired in ASD [Mann & Walker, ; Grossman, Edelson, & Tager‐Flusberg, ; Robertson, Kravitz, Freyberg, Baron‐Cohen, & Baker, ; Oerlemans et al, ]. Finally, the forceps major provides interhemispheric integration between left and right visual fields [Aboitiz, Scheibel, Fisher, & Zaidel, ; Gazzaniga, ; Arguin et al, ; Schmahmann & Pandya, ; Yamada et al, ], and any compromise may relate to atypical visual spatial attention and extensive differences in functional asymmetries in ASD [Haist, Adamo, Westerfield, Courchesne, & Townsend, ; Cardinale, Shih, Fishman, Ford, & Müller, ].…”

Section: Discussionmentioning

confidence: 99%

White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging

2017

View full text Add to dashboard Cite

Scientific abstract Background Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. Methods We included 57 ASD and 50 TD participants, comparing 3 subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM). Groups were compared on diffusivity measures using Tract-Based Spatial Statistics (TBSS) and probabilistic tractography. Two methods for estimating diffusivity were compared: dti-fit and restore. Results TBSS: In set FS, FA was reduced in the ASD compared to the TD group throughout the right hemisphere. This effect was less extensive in set QC and absent in set QM. However, effect sizes remained stable or increased with better quality-control in some regions. Tractography: In set QM, MD was significantly higher in ASD overall and RD was higher in bilateral ILF. Effects were more robust in QM than in FS or QC sets. Effect sizes in several tracts increased with stringent quality matching. Restore improved tensor estimates, with some increases in effect sizes, but did not fully compensate for reduced quality. Conclusions Findings suggest that some previously reported DTI findings for ASD may have been confounded by motion. However, effects in tightly matched subset indicate that tract-specific anomalies probably do exist in ASD. Our results highlight the need for careful quality-control and motion-matching.

show abstract

Attention and spatial cognition: Neural and anatomical substrates of visual neglect

Cited by 86 publications

References 55 publications

Anatomical predictors of successful prism adaptation in chronic visual neglect

Anatomical predictors of successful prism adaptation in chronic visual neglect

Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging

Contact Info

Product

Resources

About