Attention and non-REM sleep in neuroleptic-naive persons with schizophrenia and control participants

Forest, Geneviève; Poulin, Julie; D’Aoust, Anne-Marie; Lussier, Isabelle; Stip, Émmanuel; Godbout, Roger

doi:10.1016/j.psychres.2005.11.005

Cited by 56 publications

(55 citation statements)

References 37 publications

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“…Three early studies of small samples (n:511) of APD-naïve first-episode (25, 69) and unmedicated (70, 71) SZ patients did not find a spindle deficit (Table 1). A growing literature, however, reports marked reductions of spindle activity In chronic medicated SZ (31, 72-76) and medicated adolescents with early onset SZ spectrum disorder (77).…”

Section: Sleep Spindle Deficit In Szmentioning

confidence: 98%

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Manoach

Pan

Purcell

et al. 2016

Biological Psychiatry

184

155

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Although schizophrenia is defined by waking phenomena, abnormal sleep is a common feature. In particular, there is accumulating evidence of a sleep spindle deficit. Sleep spindles, a defining thalamocortical oscillation of non-rapid eye movement Stage 2 sleep, correlate with IQ and are thought to promote long-term potentiation and enhance memory consolidation. Here we review evidence that reduced spindle activity in schizophrenia is an endophenotype that impairs sleep-dependent memory consolidation, contributes to symptoms and is a novel treatment biomarker. Studies showing that spindles can be pharmacologically enhanced in schizophrenia and that increasing spindles improves memory in healthy individuals suggest that treating spindle deficits in schizophrenia may improve cognition. Spindle activity is highly heritable and recent large-scale genome-wide association studies have identified schizophrenia risk genes that may contribute to spindle deficits and illuminate their mechanisms. For example, the schizophrenia risk gene CACNA1I encodes a calcium channel that is abundantly expressed in the thalamic spindle generator and plays a critical role in spindle activity in a mouse knockout. Future genetic studies of animals and humans can delineate the role of this and other genes in spindles. Such cross-disciplinary research, by forging empirical links in causal chains from risk genes to proteins and cellular functions, through to endophenotypes, cognitive impairments, symptoms and diagnosis, has the potential to advance the mechanistic understanding, treatment and prevention of schizophrenia. This review highlights the importance of deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and implicates reduced sleep spindles as a potentially treatable mechanism.

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Section: Sleep Spindle Deficit In Szmentioning

confidence: 98%

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Manoach

Pan

Purcell

et al. 2016

Biological Psychiatry

184

155

View full text Add to dashboard Cite

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“…Manoach and colleagues [41] observed impairment of sleep-dependent consolidation of procedural learning. Forest and coworkers [42] demonstrated a negative correlation between the amount of stage 4 sleep and reaction time in a selective attention task. A third study by Gö der and coworkers [43] found that SWS deficits and impaired SE correlated significantly with impaired performance on a test of declarative memory.…”

Section: Clinical and Neuropsychologic Correlations Clinical Correlatesmentioning

confidence: 99%

Sleep in Schizophrenia: Impairments, Correlates, and Treatment

Benson¹

2006

Psychiatric Clinics of North America

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“…Indeed, research has shown that sleep disturbance is associated with impaired quality of life (QoL) and coping in people experiencing psychosis (Ritsner, Kurs, Ponizovsky, & Hadjez, 2004;Hofstetter, Lysaker, & Mayeda, 2005). Neuropsychological findings also demonstrate that sleep disturbance contributes to impaired performance on tasks of sustained 4 attention (Forest et al, 2007), executive functioning (Keshavan, Cashmere, Miewald, & Yeragani, 2004) and IQ (Manoach et al, 2014). However, whether these performance deficits approximate daily functioning remains unclear.…”

mentioning

confidence: 99%

High resolution examination of the role of sleep disturbance in predicting functioning and psychotic symptoms in schizophrenia: A novel experience sampling study.

Mulligan¹,

Haddock²,

Emsley³

et al. 2016

Journal of Abnormal Psychology

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Sleep disturbance is common in schizophrenia, but its role in predicting functioning and psychotic symptoms has yet to be rigorously examined. The purpose of this study was to conduct a prospective, high-resolution examination of the relationship between nightly sleep and next-day functioning and psychotic symptoms in people with a diagnosis of schizophrenia. Experience sampling methodology was integrated with actigraphy and sleep diaries across 7 days in 22 patients with a diagnosis of schizophrenia. Momentary assessments of mood, psychotic symptoms, and functioning were gathered at 5 points each day following pseudorandom schedules. Multilevel modeling was performed to evaluate the links between variables. Objective and subjective sleep disturbance predicted reduced next-day functioning, which remained significant after controlling for psychotic symptom severity. Increased sleep fragmentation and reduced subjective and objective sleep efficiency predicted greater next-day auditory hallucinations, whereas increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control. Negative affect on awakening mediated a proportion of these relationships (range: 17.9 -57.3%). For the first time, we show that sleep disturbance is a predictor of next-day impaired functioning and psychotic symptom severity in people with a diagnosis of schizophrenia. Therefore, interventions targeting sleep may have the potential to directly and indirectly enhance functional and symptomatic recovery in those experiencing psychosis.

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Attention and non-REM sleep in neuroleptic-naive persons with schizophrenia and control participants

Cited by 56 publications

References 37 publications

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Sleep in Schizophrenia: Impairments, Correlates, and Treatment

High resolution examination of the role of sleep disturbance in predicting functioning and psychotic symptoms in schizophrenia: A novel experience sampling study.

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