2016
DOI: 10.1016/j.yebeh.2016.04.011
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Attention and executive functions in the early course of pediatric epilepsy

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Cited by 27 publications
(14 citation statements)
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References 36 publications
(73 reference statements)
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“…Children and adolescents with epilepsy present with lower cognitive performance and higher rates of behavioral problems already at epilepsy onset or even before the manifestation of epilepsy compared with their healthy peers. 22,23 In pediatric epilepsy surgery cohorts, significantly lower overall cognitive performance and significantly higher rates of severe mental impairment compared with healthy children are established before surgery, depending on etiology and time variables. 3,4,6,17,24,25 Children with newly diagnosed epilepsy present with a modified pattern of brain development 26 characterized by a delayed increase of white-matter volume compared with peers.…”
Section: Presurgical Findingsmentioning
confidence: 99%
“…Children and adolescents with epilepsy present with lower cognitive performance and higher rates of behavioral problems already at epilepsy onset or even before the manifestation of epilepsy compared with their healthy peers. 22,23 In pediatric epilepsy surgery cohorts, significantly lower overall cognitive performance and significantly higher rates of severe mental impairment compared with healthy children are established before surgery, depending on etiology and time variables. 3,4,6,17,24,25 Children with newly diagnosed epilepsy present with a modified pattern of brain development 26 characterized by a delayed increase of white-matter volume compared with peers.…”
Section: Presurgical Findingsmentioning
confidence: 99%
“…The disturbance of executive functions in epileptic children may be caused by a number of factors, such as the underlying lesion and/or its neuro-developmental effects, interictal epileptic activity, the total drug load, drug interactions, and the lack of drive and motivation due to depression [9][10][11][12][13][14]. Recently, impaired executive functions were reported in newly diagnosed drug naïve epileptic children [15]. In the current study, children treated with AEDs that affected cognitive function or those having secondary epilepsy were excluded so we can assume that epilepsy per se plays a fundamental role in the development of cognitive deficit irrespective of other associated factors including sleep disturbance.…”
Section: Discussionmentioning
confidence: 99%
“…Считается, что при локальности эпилептогенной зоны в эпилептогенезе участвует весь мозг и подобный «эпилептический мозг» отличается от здорового мозга [7]. Нарушение индивидуального развития ребенка связывают с порой необратимым влиянием частых приступов и антиэпилептических препаратов на развивающийся мозг, при этом нередко не так важна этиология эпилепсии [7][8][9][10][11][12][13][14]. Доказано отрицательное влияние тяжести приступов на психосоциальный статус ребенка [10][11][12][13].…”
unclassified
“…Нарушение индивидуального развития ребенка связывают с порой необратимым влиянием частых приступов и антиэпилептических препаратов на развивающийся мозг, при этом нередко не так важна этиология эпилепсии [7][8][9][10][11][12][13][14]. Доказано отрицательное влияние тяжести приступов на психосоциальный статус ребенка [10][11][12][13]. Когнитивное функционирование и поведение детей с эпилепсией нарушены не только при длительном течении заболевания, но и иногда до его манифестации [7].…”
unclassified
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