Attempts to Improve Lipophilic Drugs’ Solubility and Bioavailability: A Focus on Fenretinide
Silvana Alfei,
Guendalina Zuccari
Abstract:The development of numerous drugs is often arrested at clinical testing stages, due to their unfavorable biopharmaceutical characteristics. It is the case of fenretinide (4-HPR), a second-generation retinoid, that demonstrated promising in vitro cytotoxic activity against several cancer cell lines. Unfortunately, response rates in early clinical trials with 4-HPR did not confirm the in vitro findings, mainly due to the low bioavailability of the oral capsular formulation that was initially developed. Capsular … Show more
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