Attempt to control an artificial heart system using sympathetic nervous signals

Mabuchi, Kunihiko; Kanbara, Osamu; Kunimoto, Masanari; Suzuki, Takafumi; Igarashi, Takashi; Haeno, Shigehiko; Genno, Hirokazu

doi:10.1109/iembs.1998.745946

Cited by 5 publications

(4 citation statements)

References 2 publications

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“…A future application of the novel intrafascicular nerve electrode for controlling a total artificial heart (TAH) using autonomic neural information is under development in our group. 2 Although several TAH control methods using cardiac hemodynamic parameters have been proposed, 7,8 a control algorithm similar to that of a natural heart has not been achieved yet. By developing a novel control method using the novel nerve electrode, the autonomic nervous system could control the TAH as is done with a natural heart, improving the quality of life of patients with TAHs.…”

Section: Discussionmentioning

confidence: 99%

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Development of a Novel Intrafascicular Nerve Electrode

Mitsui

Suzuki²,

Mabuchi³

et al. 2005

ASAIO Journal

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Artificial organs could be controlled using autonomic neural signals, because they exhibit rapid responses to physical needs similar to those of natural organs. A nerve electrode must satisfy many requirements to measure autonomous neural signals such as a long lifetime, high signal-to-noise ratio, multichannel recording, simple installation into a nerve fascicle, and good manufacturing productivity. The purpose of our study is to propose and evaluate a novel nerve electrode that satisfies these conditions, which to date has not been developed. A novel intrafascicular nerve electrode was designed, fabricated, and evaluated on autonomic nerves. Conventional extrafascicular and intrafascicular nerve electrodes were fabricated and tested for comparison to our novel intrafascicular nerve electrode. The novel intrafascicular nerve electrode had a 3-week lifetime, whereas the conventional extrafascicular nerve electrode had a 2-week lifetime. The signal-to-noise ratio was improved from 1.6 to 2.0 compared with the conventional extrafascicular nerve electrode. The novel intrafascicular nerve electrode was easier to install into a nerve fascicle and had better manufacturing productivity than the conventional intrafascicular nerve electrode. We succeeded in demonstrating the feasibility of our novel intrafascicular nerve electrode.

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Section: Discussionmentioning

confidence: 99%

“…In our study, the detection of the onset of neural activity is important for controlling artificial internal organs. 2 The signal-to-noise ratio of the conventional extrafascicular nerve electrode was 1.6.…”

mentioning

confidence: 99%

Development of a Novel Intrafascicular Nerve Electrode

Mitsui

Suzuki²,

Mabuchi³

et al. 2005

ASAIO Journal

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“…For example, the National Cardiovascular Center carried out nervus sympathicus recording experiments with mechanical supporting circulation after our reports on the recording of renal sympathetic nerve discharges during ventricular assistance ( 1, 14). The University of Tokyo presented an idea to control an artificial heart with sympathetic nerve information after our reports showing the feasibility of the predictive control of an artificial heart by the use of information of the sympathetic nerve discharges ( 15, 16). However, these reports were only in acute animal experiments, and no report showed the autonomic nerve discharges in chronic animal experiments.…”

Section: Discussionmentioning

confidence: 99%

Vagal Nerve Activity Recording in the Awake Condition for the Control of an Artificial Heart System

et al. 1999

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To detect useful information for an artificial heart control system, we paid attention to the autonomic nervous system. For stable recording, we used vagal nerve activity in chronic animal experiments using healthy adult goats in an awake condition because this nerve was sufficiently bold and large enough. Vagal nerve discharges were successfully recorded from awake goats. They were synchronized with respiration and responded to the hemodynamic changes induced by drug administration, suggesting that they may provide useful information for an artificial heart control algorithm. For automatic control, some time delay plays a vitally important role. Thus, predictive control for an artificial heart system may be desirable. It may be embodied by the use of autonomic nerve information.

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“…As the preliminary step of this research, the authors have already reported an off-line experiment to control an artificial heart system using skin sympathetic nervous signals [4]. In this experiment, we used skin sympathetic nerve activity (SSNA) recorded by microneurography techniques as the parameter to determine the condition of an artificial heart system.…”

Section: Control Of Artificial Hearts Using Autonomic Nervous Signalsmentioning

confidence: 99%

Control of artificial hearts using autonomic nervous signals

Suzuki

Mitsui

Inagaki

et al.

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-In order to develop an artificial heart system capable of being controlled by autonomic nervous signals, we have studied the methods of long-term stable recording of autonomic nervous signals and algorisms to utilize those signals to control an artificial heart system optimally. In this study, we have focused on the feasibility of the control of an artificial heart using the signals recorded from the cardiac sympathetic nerve and other nerves through animal experiments. INTRODUCTIONThe development of a man-machine interface that can allow information to be sent by the human nervous system to control external equipment is extremely important for the development of the next generation of prosthetic devices, including artificial organs and limbs.On the other hand, with regard to the control method of artificial heart systems, no definitive and reliable method has yet been developed, although several methods have been proposed and tested [1] [2]. No methods have the necessary properties to respond to the variable demands of the living body. Our focus is on a method that uses neural information of the living body to control the artificial heart. With this method, we expect to achieve an artificial heart that can be controlled according to the demands of the natural circulatory center (Figure 1).In order to realize neural prosthetic applications like this one, two essential problems are to be solved. They are:1) how to establish a stable interface with the nervous system, and 2) how to translate the recorded nerve signals to control the artificial devices.The first problem is the development of nerve electrodes. In terms of establishing an intimate and stable interfacing with the nervous system for a long term, the present technology of nerve electrodes is insufficient in many ways. In order to cope with this problem, the authors have been developing regeneration electrodes that have multi-channel recording and stimulating sites. The research is in the animal experimental stage [3].Essentially, the target nerves where neural signals are measured are the cardiac nerves. However, it is difficult to measure the signals at this position because after implantation of the artificial heart, the cardiac nerves are too close to it and it is not possible to get a good S/N proportion. Therefore, we have also studied the use of signals recorded from the cervical autonomic nerve. To utilize the signal from this position, the signal should be properly analyzed. The second problem is related to the analysis of the coding rule of nervous systems. To cope with this problem, it is necessary to investigate how control information is expressed in autonomic nervous systems. CONTROL OF ARTIFICIAL HEARTS USING AUTONOMIC NERVOUS SIGNALSAs the preliminary step of this research, the authors have already reported an off-line experiment to control an artificial heart system using skin sympathetic nervous signals [4]. In this experiment, we used skin sympathetic nerve activity (SSNA) recorded by microneurography techniques as the paramet...

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Attempt to control an artificial heart system using sympathetic nervous signals

Cited by 5 publications

References 2 publications

Development of a Novel Intrafascicular Nerve Electrode

Development of a Novel Intrafascicular Nerve Electrode

Vagal Nerve Activity Recording in the Awake Condition for the Control of an Artificial Heart System

Control of artificial hearts using autonomic nervous signals

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