Atteinte des membres dans les DHBN-FN : étude bicentrique entre 2000 et 2017 sur la qualité de vie et impact fonctionnel

Chevet-Noel, Albin; Andreoletti, Jean-Baptiste; Kheloufi, Mohand; Pluvy, I.

doi:10.1016/j.anplas.2019.05.003

Cited by 1 publication

(5 citation statements)

References 21 publications

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“…The main limitations of the study are its monocentric and retrospective nature, with a relatively small sample size. Although the first may limit generalizability of our results, both admission characteristics and QOL measurement are in line with the literature [ 8 , 9 , 25 , 30 ]. We cannot exclude that a lack of statistical power might have accounted for the absence of significant correlation between admission characteristics and long-term QOL, as well as of significant differences in QOL between NSTI and non-NSTI ICU survivors.…”

Section: Discussionsupporting

confidence: 74%

“…MCS mental component summary; PCS physical component summary; SF-36 36-Item Short-Form Health Survey; ICU intensive care unit in terms of severity, although residual confounders may remain, such as other unrecorded comorbidities. Responders and non-responders were comparable on sex (59 vs 51% male, p = 0.440) and severity of illness as assessed by admission SAPS II [25 (18-36) vs 27 (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), p = 0.441], but there was a non-significant trend for non-responders to be older [58 (52-69) vs 66 (53-78) years, p = 0.074], and a selection bias is possible. Finally, we did not assess microbiological characteristics or therapeutic interventions and their association with QOL, although in a small-scale study E. coli infections and an important number of surgical excisions were predictors of poor outcome [30].…”

Section: Discussionmentioning

confidence: 99%

“…Responders and non-responders were comparable on sex (59 vs 51% male, p = 0.440) and severity of illness as assessed by admission SAPS II [25 (18-36) vs 27 (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), p = 0.441], but there was a non-significant trend for non-responders to be older [58 (52-69) vs 66 (53-78) years, p = 0.074], and a selection bias is possible. Finally, we did not assess microbiological characteristics or therapeutic interventions and their association with QOL, although in a small-scale study E. coli infections and an important number of surgical excisions were predictors of poor outcome [30]. Similarly, marital status has been associated with QOL for NSTI survivors, an association we did not evaluate [8,29].…”

Section: Discussionmentioning

confidence: 99%

“…We found no association between admission characteristics and QOL impairment aside from previous cardiac disease, including topographical characteristics of the infection. Although infections of the limbs have been associated with functional limitation [ 7 ], the latter has not been associated with impaired QOL, nor has articular involvement [ 30 ]. Moreover, specific fields of QOL could be affected for perineal infections such as sexual function [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, specific fields of QOL could be affected for perineal infections such as sexual function [ 13 ]. Results regarding the association between the percentage of body surface area affected and QOL are conflicting [ 7 , 8 , 30 ]. Age, although only associated with PCS in univariate analysis in our study, likely because of its interdependence with the variable cardiac disease, has been shown to be the admission characteristic most consistently associated with long-term QOL in other studies [ 8 , 9 , 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Long-term quality of life in necrotizing soft-tissue infection survivors: a monocentric prospective cohort study

Urbina

Canouï‐Poitrine

Chen

et al. 2021

Ann. Intensive Care

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Background Compared to other life-threatening infection survivors, long-term health-related quality of life (QOL) of patients surviving necrotizing soft-tissue infections (NSTI) and its determinants are little known. In this monocentric prospective cohort including NSTI survivors admitted between 2014 and 2017, QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36), the Hospital Anxiety and Depression (HAD), the activity of daily living (ADL), instrumental ADL (IADL) scales and the Impact of Event Scale-Revised (IES-R). The primary outcome measure was the SF-36 physical component summary (PCS). NSTI patients were compared according to intensive care unit (ICU) admission status. ICU survivors were matched on SAPS II with non-NSTI related septic shock survivors. Results Forty-nine NSTI survivors were phone-interviewed and included in the study. Median PCS was decreased compared to the reference population [− 0.97 (− 2.27; − 0.08) SD]. Previous cardiac disease was the only variable associated with PCS alteration [multivariate regression coefficient: − 8.86 (− 17.64; − 0.07), p = 0.048]. Of NSTI survivors, 15.2% had a HAD-D score ≥ 5 and 61.2% an IES-R score ≥ 33. ICU admission was not associated with lower PCS [35.21 (25.49–46.54) versus (vs) 41.82 (24.12–51.01), p = 0.516], but with higher IES-R score [14 (7.5–34) vs 7 (3–18), p = 0.035] and a higher proportion of HAD-D score ≥ 5 (28.6 vs 4.0%, p = 0.036). Compared to non-NSTI septic shock-matched controls, NSTI patients had similar PCS [33.81 (24.58; − 44.39) vs 44.87 (26.71; − 56.01), p = 0.706] but higher HAD-D [3.5 (1–7) vs 3 (1.5–6), p = 0.048] and IES-R scores [18 (8–35) vs 8 (3–19), p = 0.049]. Conclusions Long-term QOL in NSTI survivors is severely impaired, similarly to that of non-NSTI septic shock patients for physical compartments, but with more frequent depressive and/or post-traumatic stress disorders. Only ICU admission and previous cardiac disease were predictive of QOL impairment.

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