Attainment of Guideline-Directed Medical Treatment in Stable Ischemic Heart Disease Patients With and Without Chronic Kidney Disease

Koutroumpakis, Efstratios; Gosmanova, Elvira O.; Stahura, Heather; Jou, Stephanie; Alreshq, Rabah; Ata, Ashar; Sidhu, Mandeep S.; Philbin, Edward F.; Boden, William E.; Lyubarova, Radmila

doi:10.1007/s10557-019-06883-z

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Patients with CKD stage 3 received the highest rate of renin-angiotensin system blockers (80.1% for CKD stage 3a and 79.7% for CKD stage 3b), but this rate decreased to 70.4% in patients with eGFR <30mL/min/1.73 m 2 . In addition to the higher burden of comorbidities [20], suboptimal secondary prevention may contribute in part to the higher event rates observed with more advanced CKD [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry

Vidal‐Petiot

Greenlaw

Kalra

et al. 2019

JCM

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Chronic kidney disease (CKD) is associated with an increased cardiovascular risk in a broad spectrum of populations. However, the risk associated with a reduced estimated glomerular filtration rate (eGFR) in patients with stable coronary artery disease receiving standard care in the modern era, independently of baseline cardiovascular disease, risk factors, and comorbidities, remains unclear. We analyzed data from 21,911 patients with stable coronary artery disease, enrolled in 45 countries between November 2009 and July 2010 in the CLARIFY registry. Patients with abnormal renal function were older, with more comorbidities, and received slightly lower-although overall high-rates of evidence-based secondary prevention therapies than patients with normal renal function. The event rate of patients with CKD stage 3b or more (eGFR <45 mL/min/1.73 m 2 ) was much higher than that associated with any comorbid condition. In a multivariable adjusted Cox proportional hazards model, lower eGFR was independently associated with a graded increased risk of cardiovascular mortality, with adjusted HRs (95% CI) of 0.98 (0., and <30 mL/min/1.73 m 2 , compared with eGFR ≥90 mL/min/1.73 m 2 . A strong graded independent relationship exists between the degree of CKD and cardiovascular mortality in this large cohort of patients with chronic coronary artery disease, despite high rates of secondary prevention therapies. Among clinical risk factors and comorbid conditions, CKD stage 3b or more is associated with the highest cardiovascular mortality.

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Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry

Vidal‐Petiot

Greenlaw

Kalra

et al. 2019

JCM

View full text Add to dashboard Cite

show abstract

“…Patients with chronic kidney disease (CKD) have higher burden of cardiovascular events when compared to those without renal dysfunction [1]. The high incidence of traditional cardiovascular risk factors was observed in the CKD population, such as hypertension, diabetes mellitus, hyperlipidemia and so on [2,3]. Besides, CKD itself is an independent risk factor for adverse cardiovascular events, which may lead to poor prognosis [4].…”

Section: Introductionmentioning

confidence: 99%

The relationship between lipoprotein(a) and cardiovascular events in acute coronary syndrome patients with and without chronic kidney disease

Chen

et al. 2022

Atherosclerosis

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Efectividad y seguridad del uso de inhibidores de PCSK9 en el tratamiento de la dislipidemia en el paciente con insuficiencia renal

2020

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Attainment of Guideline-Directed Medical Treatment in Stable Ischemic Heart Disease Patients With and Without Chronic Kidney Disease

Cited by 4 publications

References 33 publications

Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry

Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry

The relationship between lipoprotein(a) and cardiovascular events in acute coronary syndrome patients with and without chronic kidney disease

Efectividad y seguridad del uso de inhibidores de PCSK9 en el tratamiento de la dislipidemia en el paciente con insuficiencia renal

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