Attainment of Emulsions with Liquid Crystal from Marigold Oil Using the Required HLB Method

Santos, Orlando David Henrique dos; Miotto, Juliana Violi; Morais, Jacqueline M.; Rocha‐Filho, Pedro Alves da; Oliveira, Wanderley Pereira de

doi:10.1081/dis-200045610

Cited by 50 publications

(31 citation statements)

References 7 publications

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“…The average values concerning the flow index of liquid crystalline systems (Table II) reveal no significant changes during the time of analysis (T7, T15 and T30), while allowing classifying the systems rheologically in pseudoplastic behaviour (where ή <1, and ή = flow index). The pseudoplastic behavior is considered suitable for topical products, because after the application of a shear force, initial resistance for cosmetic flow decreases, reflecting the best application and spreadability of the product, as well as optimizing the sensory thereof (Morais et al, 2005). Table III shows that for both systems studied there was loss of viscosity, particularly after 15 days of preparation of the formulations.…”

Section: Resultsmentioning

confidence: 93%

“…Figure 4 is evidence that, independent of the systems, only the presence of lamellar phases was observed, which is most convenient for dermal and transdermal systems (Chorilli et al, 2011). The liquid crystal lamellar kind is responsible to increase the stability because the lamellar structures make a protection around the globules, inhibiting the adhesion and the coalescence (Morais, 2006;Morais et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…From this point of view, it is possible to recognize and identify structures of intermediate characteristics between the solid and liquid matter state, more commonly known as liquid crystals (LCs), (Nesseem, 2001;Muller-Goymann, 2004;Bechtold, 2005;Souza et al, 2012;Santos et al, 2013). Thus, LCs have been characterized by presenting a intermediate molecular order degree (Bechtold, 2005;Tyle, 1989;Santos et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application

Silva

Lacerda

Bernegossi

et al. 2016

Braz. J. Pharm. Sci.

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Liquid-Crystalline Systems represent active compounds delivery systems that may be able to overcome the physical barrier of the skin, especially represented by the stratum corneum. To obtain these systems, aqueous and oily components are used with surfactants. Of the different association structures in such systems, the liquid-crystalline offer numerous advantages to a topical product. This manuscript presents the development of liquid-crystalline systems consisting, in which the oil component is olive oil, its rheological characterizations, and the location of liquid crystals in its phase map. Cytotoxic effects were evaluated using J-774 mouse macrophages as the cellular model. A phase diagram to mix three components with different proportions was constructed. Two liquid crystalline areas were found with olive oil in different regions in the ternary diagram with two nonionic surfactants, called SLC1 (S1) and SLC2 (S2). These systems showed lamellar liquid crystals that remained stable during the entire analysis time. The systems were also characterized rheologically with pseudoplastic behavior without thixotropy. The texture and bioadhesion assays showed that formulations were similar statistically (p < 0.05), indicating that the increased amount of water in S2 did not interfere with the bioadhesive properties of the systems. In vitro cytotoxic assays showed that formulations did not present cytotoxicity. Olive oil-based systems may be a promising platform for skin delivery of drugs. Uniterms: Liquid-Crystalline Systems/development. Liquid-Crystalline Systems/reology. Drugs/skin delivery. Olive Oil/use/Liquid-Crystalline Systems. Rheology. Cytotoxicity. Bioadhesion. Os cristais líquidos representam um sistema de liberação de substâncias ativas capazes de vencer a barreira cutânea, representada especialmente pelo estrato córneo. Água, óleo e tensoativos são misturados para se obter esses sistemas. Diferentes estruturas podem ser formadas nesses sistemas, as quais oferecem muitas vantagens para os produtos de uso tópico. Esse trabalho visou ao desenvolvimento de sistemas líquido-cristalinos preparados com óleo de oliva, sua caracterização reológica e a identificação das fases cristalinas no diagrama ternário. Efeitos citotóxicos foram avaliados usando células de rato como modelo celular. Construiu-se um diagrama de fases que mistura três componentes em diferentes proporções. Duas áreas de cristal líquido, denominadas SLC1 (S1) e SLC2 (S2), foram encontradas com óleo de oliva em diferentes regiões no diagrama ternário preparado com dois diferentes tensoativos não-iônicos. Esses sistemas mostraram fase cristalina lamelar, que permaneceu estável durante o tempo estudado. Os sistemas foram também caracterizados reologicamente e apresentaram comportamento pseudoplástico com tixotropia. Os ensaios de textura e bioadesão mostraram que as formulações foram similares (p < 0.05), indicando que o aumento da quantidade de água em S2 não interferiu nas propriedades bioadesivas dos sistemas. Os ensaios de citotoxicidade mostra...

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application

Silva

Lacerda

Bernegossi

et al. 2016

Braz. J. Pharm. Sci.

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“…However, there were variations in rheological behavior, due to variation in the surfactants. 82 Santos and Rocha-Filho developed a formulation for previously-identified lamellar LC phases, to ascertain the influence of the length of carbon chain and the number of ethylene oxide units on the stability of a nonionic emulsion, using marigold oil from seeds and flowers of C. officinalis. The system contained marigold oil, distilled water, and several polyoxyethylene alkyl or stearyl ethers (surfactants): polyoxyethylene cetyl ether (Ceteth-2; HLB: 5.1), polyoxyethylene stearyl ether (Steareth-2; HLB: 4.7), polyoxyethylene cetyl ether (Ceteth-10; HLB: 11.0), and polyoxyethylene stearyl ether (Steareth-20; HLB: 15.3).…”

Section: Liquid Crystalline Systemsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems and herbal medicines: a review

Bonifácio¹,

Silva²,

Ramos³

et al. 2013

IJN

251

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Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

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“…Three regions of the slide were evaluated randomly to verify the samples homogeneity. The experiment were conducted at room temperature (25.0 ± 2.0 °C), with further counting of the inner phase droplets performed by the equipment software Image ® Pro Plus (Masson et al, 2005;Santos et al, 2005).…”

mentioning

confidence: 99%

Particle size and morphological characterization of cosmetic emulsified systems by Optical Coherence Tomography (OCT)

Prestes

Peres

Freitas

et al. 2016

Braz. J. Pharm. Sci.

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The physicochemical attributes of emulsified systems are influenced by the characteristics of their internal phase droplets (concentration, size and morphology), which can be modified not only by the formulation components, but also by the analytical methodology employed. Thus, the aim of this work involved the physicochemical characterization of cosmetic emulsions obtained from different surfactants, as well as the introduction of the optical coherence tomography (OCT) as the analytical technique employed for the morphological characterization and particle size determination of the formulations. Three emulsions were prepared, differing at the type and concentration of the surfactant used, and their droplet sizes were evaluated through optical microscopy, laser diffraction and OCT. The microscopic analysis and the laser diffraction techniques provided an average particle size minor than 6.0 µm, not detected by the OCT technique, which could identify only bigger particles of the emulsified systems' internal phase. The results testify that OCT was suitable for the morphological characterization of cosmetic emulsions; however, the technique needs to be improved to ensure a better sensitivity in the analysis of smaller particles.Uniterms: Cosmetic emulsions/physicochemical characterization. Surfactants. Optical coherence tomography/morphological characterization. Optical microscopy/morphological characterization. Laser diffraction/morphological characterization.Os atributos físico-químicos de sistemas emulsionados são influenciados pelas características de suas gotículas de fase interna (concentração, tamanho e morfologia), as quais podem ser modificadas não apenas pelos componentes da formulação, mas também pela metodologia analítica empregada. Desta forma, o objetivo deste trabalho envolveu a caracterização físico-química de emulsões cosméticas obtidas a partir de diferentes tensoativos, bem como a introdução da tomografia de coerência óptica (OCT) como a técnica analítica utilizada para a caracterização morfológica e determinação do tamanho de partícula das formulações. Três emulsões foram preparadas, diferindo no tipo e concentração do tensoativo empregado, e seus tamanhos de gotícula foram avaliados por meio das técnicas de microscopia óptica, difração a laser e OCT. As técnicas de microscopia óptica e difração a laser forneceram tamanhos de partícula médios menores de 6.0 µm, não detectados pela técnica de OCT, que permitiu apenas a identificação de partículas maiores pertencentes à fase interna dos sistemas emulsionados. Os resultados reforçam a introdução da OCT como metodologia promissora para a caracterização morfológica de emulsões cosméticas; no entanto, a técnica requer aprimoramento para garantir maior sensibilidade na análise de partículas de menor tamanho.Unitermos: Emulsões cosméticas/caracterização físico-química. Tensoativos. Tomografia de coerência óptica/caracterização morfológica. Microscopia óptica/ caracterização morfológica. Difração a laser/ caracterização morfológica.

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Attainment of Emulsions with Liquid Crystal from Marigold Oil Using the Required HLB Method

Cited by 50 publications

References 7 publications

Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application

Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application

Nanotechnology-based drug delivery systems and herbal medicines: a review

Particle size and morphological characterization of cosmetic emulsified systems by Optical Coherence Tomography (OCT)

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