Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, Le; Wei, Jessica; Liu, Pengda

doi:10.1016/j.semcancer.2021.06.019

Cited by 233 publications

(150 citation statements)

References 447 publications

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“…These processes involve various signaling pathways, including PI3K/Akt/mTOR signaling, Wnt/β-catenin signaling, signaling, and RhoA-ROCK signaling. It has been confirmed that these pathways play indispensable roles in tumorigenesis and disease progression [ 133 , 134 , 135 , 136 ]. However, PCAT6 can regulate the signaling pathways through ceRNA [ 26 ] and other mechanisms [ 28 ].…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers

Jiang

et al. 2021

Cancers

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LncRNAs are involved in the occurrence and progressions of multiple cancers. Emerging evidence has shown that PCAT6, a newly discovered carcinogenic lncRNA, is abnormally elevated in various human malignant tumors. Until now, PCAT6 has been found to sponge various miRNAs to activate the signaling pathways, which further affects tumor cell proliferation, migration, invasion, cycle, apoptosis, radioresistance, and chemoresistance. Moreover, PCAT6 has been shown to exert biological functions beyond ceRNAs. In this review, we summarize the biological characteristics of PCAT6 in a variety of human malignancies and describe the biological mechanisms by which PCAT6 can facilitate tumor progression. Finally, we discuss its diagnostic and prognostic values and clinical applications in various human malignancies.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers

Jiang

et al. 2021

Cancers

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“…The PI3K/AKT/mTOR signaling pathway plays an important role in cell cycle regulation and is involved in cell metabolism, proliferation, apoptosis, and carcinogenesis ( 112 , 113 ). Numerous cell surface RTKs are involved in the pathways, including insulin receptor (InsR), EGFR, platelet-derived growth factor receptor (PDGFR), hepatocyte growth factor receptor (HGFR), discoidin domain receptor (DDR), leukocyte tyrosine kinase (LTK), and others, which have high affinity for numerous polypeptide growth factors, cytokines, and hormones and are activated by them ( 114 ).…”

Section: Action Mechanism Of Iqgaps In Hccmentioning

confidence: 99%

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma

et al. 2022

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IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer initiation and progression has received increasing attention in recent years, especially in hepatocellular carcinoma (HCC), where the aberrant expression of IQGAPs is closely related to patient prognosis. IQGAP1 and 3 are upregulated and are considered oncogenes in HCC, while IQGAP2 is downregulated and functions as a tumor suppressor. This review details the three IQGAP isoforms and their respective structures. The expression and role of each protein in different liver diseases and mainly in HCC, as well as the underlying mechanisms, are also presented. This review also provides a reference for further studies on IQGAPs in HCC.

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“…Certain mechanisms ( Figure 3 ) are involved in chemoresistance of triple-negative breast cancer, and the mTOR signaling pathway is one among these mechanisms. As discussed earlier, the PI3K-AKT-mTORsignaling pathway controls and regulates proliferation, growth, survival, and motility within cellular environment [ 125 ]. Phosphatase and tensin homolog (PTEN) is a tumor suppressor that negatively regulates the activity of the PI3K-AKT-mTOR signaling pathway [ 125 ].…”

Section: Flavonoids Targeting Mtor In Breast Cancer and Chemoresistancementioning

confidence: 99%

Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy

Hussain

Khan

Alam

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cancer is one of the leading causes of death worldwide. Breast cancer is the second leading cause of death in women, with triple-negative breast cancer being the most lethal and aggressive form. Conventional therapies, such as radiation, surgery, hormonal, immune, gene, and chemotherapy, are widely used, but their therapeutic efficacy is limited due to adverse side effects, toxicities, resistance, recurrence, and therapeutic failure. Many molecules have been identified and investigated as potential therapeutic agents for breast cancer, with a focus on various signaling pathways. Flavonoids are a versatile class of phytochemicals that have been used in cancer treatment to overcome issues with traditional therapies. Cell proliferation, growth, apoptosis, autophagy, and survival are all controlled by mammalian target of rapamycin (mTOR) signaling. Flavonoids target mTOR signaling in breast cancer, and when this signaling pathway is regulated or deregulated, various signaling pathways provide potential therapeutic means. The role of various flavonoids as phytochemicals in targeting mTOR signaling pathways in breast cancer is highlighted in this review.

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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Cited by 233 publications

References 447 publications

PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers

PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma

Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy

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