Attack behaviors in mice: From factorial structure to quantitative trait loci mapping

Roubertoux, Pierre L.; Guillot, Pascale V.; Mortaud, Stéphane; Pratte, M.; Jamon, Marc; Cohen-Salmon, Charles; Tordjman, Sylvie

doi:10.1016/j.ejphar.2005.09.026

Cited by 50 publications

(61 citation statements)

References 73 publications

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“…Miczek et al 2002;Haller and Kruk 2006). Several studies focus on the magnitude of aggression in relation to socioenvironmental (Sprott and Staats 1975), neurological and neuro-pharmacological manipulations (Nikulina 1991;Robertoux et al 2005;Crawley et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Delineation of Violence from Functional Aggression in Mice: An Ethological Approach

et al. 2008

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The present study aims at delineating violence from aggression, using genetically selected high (SAL, TA, NC900) and low (LAL, TNA NC100) aggressive mouse strains. Unlike aggression, violence lacks intrinsic control, environmental constraints as well as functional endpoints. Conventional measures namely latency, frequency and duration were used initially to accomplish the objective of delineation using the above strains. However, these quantitative measures fail to reveal further details beyond the magnitude of differential aggression, especially within the high aggressive mouse strains. Hence, it was necessary to analyze further, the behavioral sequences that make up the agonistic encounter. Novel measures such as threat/ (attack ? chase) (T/AC) and offense/withdrawal (O/W) ratios, context dependency and first-order Markov chain analysis were used for the above purpose. Our present analyses reveal clear qualitative behavioral differences between the three high aggressive selection strains based on the following facets namely structure and context in an agonistic interaction. Structure refers to a detailed study of the agonistic interaction components (ritualistic display, offense and sensitivity to the opponent submission cues) between any two subjects (inter-male interaction for the present study). Context refers to the capacity to identify an opponent by nature of its state (free moving/anesthetized), sex and the environment (home/neutral territory). NC900 displayed context dependency and structurally a rich repertoire of agonistic interaction components with an opponent. SAL failed to show discrimination and its intermale agonistic behavior is restricted to a repetitive and an opponent-insensitive pattern of attack and chase. TA was comparable to SAL in terms of the structure but sensitive to context variables. Thus, SAL seems to display a violent form of aggressive behavior, while NC900 display 'functional' hyperaggression against a docile opponent in an inter-male agonistic interaction.

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Section: Introductionmentioning

confidence: 99%

Delineation of Violence from Functional Aggression in Mice: An Ethological Approach

et al. 2008

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“…physical condition, age, body weight [Bartosˇand Brain, 1986;Hilakivi-Clarke and Lister, 1992] or health status), population density [Greenberg, 1972], territory ownership [Gray et al, 2002;Van Loo et al, 2001], and the presence of food [Bartosˇand Brain, 1993], shelter, and females [Hayashi and Tomihara, 2000]. Therefore, in order to analyze the potential role of factors in modulating male aggressiveness, its complex nature, including both intrinsic and extrinsic factors, needs to be taken into account [Roubertoux et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

“…Genetic studies have suggested that at least two sex-linked and several autosomal loci are associated with variation in fighting behavior [Brodkin et al, 2002;Roubertoux et al, 2005;Selmanoff et al, 1975;Sluyter et al, 1994]. At the individual level, the outcome of male aggression is modulated by a variety of non-genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a,b;Natarajan et al, 2009a], pre-and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g.…”

Section: Introductionmentioning

confidence: 99%

“…At the individual level, the outcome of male aggression is modulated by a variety of non-genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a,b;Natarajan et al, 2009a], pre-and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g. Brain and Parmigiani, 1990;Hoffmann et al, 1993;Roubertoux et al, 2005;Van Loo et al, 2001]. Moreover, the actual level of male aggressiveness is strongly contextdependent, and correlated with the resource holding potential [Parker, 1974] of individual males.…”

Section: Introductionmentioning

confidence: 99%

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No postnatal maternal effect on male aggressiveness in wild-derived strains of house mice

2010

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Male aggressiveness is a complex behavior influenced by a number of genetic and non-genetic factors. Traditionally, the contribution of each of these factors has been established from experiments using artificially selected strains for high/low aggressive phenotypes. However, little is known about the factors underlying aggressive behavior in natural populations. In this study, we assess the influence of genetic background vs. postnatal maternal environment using a set of cross-fostering experiments between two wild-derived inbred strains, displaying high (STRA, derived from Mus musculus domesticus) and low (BUSNA, derived from Mus musculus musculus) levels of aggressiveness. The role of maternal environment was tested in males with the same genetic background (i.e. strain origin) reared under three different conditions: unfostered (weaned by mother), infostered (weaned by an unfamiliar dam from the same strain), and cross-fostered (weaned by a dam from a different strain). All males were tested against non-aggressive opponents from the A/J inbred strain. Resource-holding potential was assessed through body weight gains and territory ownership. The STRA males were shown to be aggressive in both neutral cage and resident-intruder tests. On the contrary, the BUSNA males were less aggressive in all tests. We did not find a significant effect of postnatal maternal environment; however, we detected significant maternal effect on body weight with differences between the strains, fostering type and interactions between these factors. We conclude that the aggressiveness preserved in the two strains has significant genetic component whose genetic basis can be dissected by quantitative trait loci analysis.

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“…In both vertebrate and invertebrate nervous systems, numerous genes of widely varying functions have been identified as important contributors to aggression (2)(3)(4)(5)(6)(7)(8), including small molecules, biogenic amines, and peptide transmitter-related genes, their receptors, and their second messenger targets (9)(10)(11)(12)(13)(14)(15); steroid hormones and their membrane and nuclear receptor targets (16,17); transcription regulators (18); and key metabolic regulators (16,19,20). Many of these genes were identified using transgenic mutants directed at specific genes.…”

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confidence: 99%

Putative transmembrane transporter modulates higher-level aggression in Drosophila

Chowdhury

Chan

Kravitz

2017

Proc. Natl. Acad. Sci. U.S.A.

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By selection of winners of dyadic fights for 35 generations, we have generated a hyperaggressive Bully line of flies that almost always win fights against the parental wild-type Canton-S stock. Maintenance of the Bully phenotype is temperature dependent during development, with the phenotype lost when flies are reared at 19 °C. No similar effect is seen with the parent line. This difference allowed us to carry out RNA-seq experiments and identify a limited number of genes that are differentially expressed by twofold or greater in the Bullies; one of these was a putative transmembrane transporter, CG13646, which showed consistent and reproducible twofold down-regulation in Bullies. We examined the causal effect of this gene on the phenotype with a mutant line for CG13646, and with an RNAi approach. In all cases, reduction in expression of CG13646 by approximately half led to a hyperaggressive phenotype partially resembling that seen in the Bully flies. This gene is a member of a very interesting family of solute carrier proteins (SLCs), some of which have been suggested as being involved in glutamine/glutamate and GABA cycles of metabolism in excitatory and inhibitory nerve terminals in mammalian systems.

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Attack behaviors in mice: From factorial structure to quantitative trait loci mapping

Cited by 50 publications

References 73 publications

Delineation of Violence from Functional Aggression in Mice: An Ethological Approach

Delineation of Violence from Functional Aggression in Mice: An Ethological Approach

No postnatal maternal effect on male aggressiveness in wild-derived strains of house mice

Putative transmembrane transporter modulates higher-level aggression in Drosophila

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