Attachment of cartilage wear particles to the synovium negatively impacts friction properties

Estell, Eben G.; Murphy, Lance A.; Gangi, Lianna R.; Shah, Roshan P.; Ateshian, Gerard A.; Hung, Clark T.

doi:10.1016/j.jbiomech.2021.110668

Cited by 11 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no consensus on the coefficient of friction between cartilage. [70][71][72] It has been suggested that the coefficient of friction of the knee joint with lubrication of the joint fluid and hydration of the cartilage is approximately 0.01, 73 and 0.02 was also used in some studies. 74 Finite element software provides a variety of algorithms for the simulation of frictionless and frictional contact.…”

Section: Contact Conditionsmentioning

confidence: 99%

“…The coefficient of friction within the joint is low, and most FEMs of the knee assumed no friction within the joint. There is no consensus on the coefficient of friction between cartilage 70–72 . It has been suggested that the coefficient of friction of the knee joint with lubrication of the joint fluid and hydration of the cartilage is approximately 0.01, 73 and 0.02 was also used in some studies 74 .…”

Section: Model Constructionmentioning

confidence: 99%

See 1 more Smart Citation

Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review

Yan,

Liang,

Zhao

et al. 2024

Orthopaedic Surgery

View full text Add to dashboard Cite

The knee is the most complex joint in the human body, including bony structures like the femur, tibia, fibula, and patella, and soft tissues like menisci, ligaments, muscles, and tendons. Complex anatomical structures of the knee joint make it difficult to conduct precise biomechanical research and explore the mechanism of movement and injury. The finite element model (FEM), as an important engineering analysis technique, has been widely used in many fields of bioengineering research. The FEM has advantages in the biomechanical analysis of objects with complex structures. Researchers can use this technology to construct a human knee joint model and perform biomechanical analysis on it. At the same time, finite element analysis can effectively evaluate variables such as stress, strain, displacement, and rotation, helping to predict injury mechanisms and optimize surgical techniques, which make up for the shortcomings of traditional biomechanics experimental research. However, few papers introduce what material properties should be selected for each anatomic structure of knee FEM to meet different research purposes. Based on previous finite element studies of the knee joint, this paper summarizes various modeling strategies and applications, serving as a reference for constructing knee joint models and research design.

show abstract

Section: Contact Conditionsmentioning

confidence: 99%

Section: Model Constructionmentioning

confidence: 99%

Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review

Yan,

Liang,

Zhao

et al. 2024

Orthopaedic Surgery

View full text Add to dashboard Cite

show abstract

“…However, in a comprehensive perspective, the friction properties of knee joint cartilage should be maintained at a low and stable level. Excessive variations in the friction coefficient can lead to instability in cartilage friction behavior [25][26][27]. Experimental observations have shown that the friction coefficient in the AGA group is more sensitive to changes in scratch velocity, exhibiting larger variations compared to pressure changes.…”

Section: Impact Of Aga On Exercisementioning

confidence: 99%

Alterations in articular cartilage frictional properties in the setting of acute gouty arthritis

Zheng,

Zhang,

Feng

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

The tribological behaviour of articular cartilage plays a key role in joint motion; however, there is a gap in research on the effect of hyperuricemic joint fluid on cartilage friction behaviour in acute gouty arthritis. In this study, we carried out a fixed-load scratch experiment to compare the friction and wear of articular cartilage under the lubrication of gouty arthritis arthritic fluid and normal human arthritic fluid, and the results showed that the cartilage friction coefficient of patients with acute gouty arthritis was significantly larger than that of normal human beings, and that the cartilage friction coefficient decreased with the elevation of normal load and sliding speed, and the change with the sliding speed varied more differently from that of normal human beings, and that the cartilage surface wear was more severe after prolonged friction. The wear and tear of the cartilage surface is more severe after prolonged friction. Patients with gouty arthritis should reduce the sudden speed changes such as fast running and variable speed running to maintain the stability of the cartilage surface friction coefficient.

show abstract

“…Additionally, there is an increase in the secretion of proteolytic enzymes, such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), which disrupts the delicate balance between catabolism and repair in the joint and contributes to cartilage degeneration and bone remodelling. In turn, the products of cartilage degradation further amplify synovial inflammation, creating a vicious circle that, if left untreated, eventually leads to joint destruction [10]. Thus, synovium-targeted therapies hold great potential for the treatment of joint diseases.…”

Section: Introductionmentioning

confidence: 99%

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment

Thompson,

Hopkins,

Bevan

et al. 2023

Biomed. Mater.

View full text Add to dashboard Cite

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis and osteoarthritis. Thus, the synovium is a promising target for the development of novel, disease-modifying therapeutics. However, target exploration is hampered by a lack of good pre-clinical models that accurately replicate human physiology and that are developed in a way that allows for widespread uptake. The current study presents a multi-channel, microfluidic, organ-on-a-chip (OOAC) model, comprising a 3D configuration of the human synovium and its associated vasculature, with biomechanical and inflammatory stimulation, built upon a commercially available OOAC platform. Healthy human fibroblast-like synoviocytes (hFLS) were co-cultured with human umbilical vein endothelial cells (HUVECs) with appropriate matrix proteins, separated by a flexible, porous membrane. The model was developed within the Emulate organ-chip platform enabling the application of physiological biomechanical stimulation in the form of fluid shear and cyclic tensile strain. The hFLS exhibited characteristic morphology, cytoskeletal architecture and matrix protein deposition. Synovial inflammation was initiated through the addition of interleukin−1β (IL−1β) into the synovium channel resulting in the increased secretion of inflammatory and catabolic mediators, interleukin-6 (IL−6), prostaglandin E2 (PGE2), matrix metalloproteinase 1 (MMP−1), as well as the synovial fluid constituent protein, hyaluronan. Enhanced expression of the inflammatory marker, intercellular adhesion molecule-1 (ICAM-1), was observed in HUVECs in the vascular channel, accompanied by increased attachment of circulating monocytes. This vascularised human synovium-on-a-chip model recapitulates a number of the functional characteristics of both healthy and inflamed human synovium. Thus, this model offers the first human synovium organ-chip suitable for widespread adoption to understand synovial joint disease mechanisms, permit the identification of novel therapeutic targets and support pre-clinical testing of therapies.

show abstract

Attachment of cartilage wear particles to the synovium negatively impacts friction properties

Cited by 11 publications

References 38 publications

Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review

Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review

Alterations in articular cartilage frictional properties in the setting of acute gouty arthritis

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment

Contact Info

Product

Resources

About