ATRP-mediated continuous assembly of polymers for the preparation of nanoscale films

Mertz, Damien; Ochs, Christopher J.; Zhu, Zhiyuan; Lee, Lillian; Guntari, Stefanie N.; Such, Georgina K.; Goh, Tor Kit; Connal, Luke A.; Blencowe, Anton; Qiao, Greg G.; Caruso, Frank

doi:10.1039/c1cc15711f

Cited by 46 publications

(64 citation statements)

References 26 publications

(28 reference statements)

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“…27–29 The CAP approach is amenable to a wide range of macrocrosslinkers consisting of pendent vinylic groups and can effectively tune the film composition and thickness. 30,31 Previously, we have demonstrated a near-linear growth of film thickness with the increase in CAP step number for PHEMA, PHEA and poly(methyl methacrylate) (PMMA) polymers.…”

Section: Introductionmentioning

confidence: 99%

The role of capsule stiffness on cellular processing

et al. 2015

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Section: Introductionmentioning

confidence: 99%

The role of capsule stiffness on cellular processing

et al. 2015

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“…(25) (27). White amorphous powder, yield 98% (after chromatography with CHCl 3 /CH 3 1'''), 72.1 (C-5'''), 71.3 (C-3'''), 71.3 (C-11), 69.8 (C-2'''), 68.9 (C-4'''), 63.9 (C-2), 62.9 (C-6''), 61.7 (C-6'''), 56.8 (3', 5'-OCH 3 ), 46.6 (C-4), 45.1 (C-1), 39.9 (C-3), 20 (29). White amorphous powder, yield 96% (after chromatography with (33).…”

Section: Click Chemistry-general Proceduresmentioning

confidence: 99%

“…Compounds 10 and 11 were prepared in 70% yield by treatment of triethylene glycol and hexaethylene glycol with sodium hydride and propargyl bromide as previous described [29,30]. Fisher glycosylation of D-glucose with propargyl alcohols 9-11 in the presence of H 2 SO 4 -silica as a catalyst [31] provided the corresponding glycosides 12-17 as α/β mixtures.…”

Section: Chemical Synthesismentioning

confidence: 99%

Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

Xu²,

et al. 2013

Molecules

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A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Most of these triazole derivatives have good anticancer activity. Among them, compound 35 showed the highest potency against all five cancer cell lines tested, with IC 50 values ranging from 0.59 to 2.90 μM, which is significantly more active than the drug etoposide currently in clinical use. Structure-activity relationship analysis reveals that the acyl substitution on the glucose residue, the length of oligoethylene glycol linker, and the 4'-demethylation of podophyllotoxin scaffold can significantly affect the potency of the anticancer activity. Most notably, derivatives with a perbutyrylated glucose residue show much higher activity than their counterparts with either a free glucose or a peracetylated glucose residue.

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“…This triacyl chloride attaches to the nanocoating through ester bonds with the hydroxyl groups and generates carboxylates after the aqueous workup. The carboxylated coatings further improved the dispersion stability through the combined electrostatic effect of the increased charge from the carboxylates and sterics that result from swelling of the carboxylated β ‐glu coating in aqueous media (Figure b) …”

Section: Resultsmentioning

confidence: 99%

Single‐Pot Encapsulation of Oxide Particles within a Polysaccharide Multilayer Nanocoating

Jankolovits

Gazit

Nigra

et al. 2015

Adv Materials Inter

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We were interested in developing a sustainable polymer encapsulation platform for oxides that allows general tuning of the surface chemistry for dispersing particles in different conditions. Our approach utilizes the synthetic tunability and unique hydrophobicity of abundant and sustainable biomass-derived polysaccharides, particularly poly(1→4)β -glucan ( β -glu) derived from crystalline cellulose. The hydrophobic character of the β -glu is evidenced by its favorable adsorption on graphitic carbon from a good solvent. [ 7 ] Until now, it has not been possible to synthesize polymer coatings directly from βglu without prior derivatization due to the phase separation of individual strands into dense and microcrystalline domains. [ 8,9 ] In this manuscript, we synthesize porous nanocoatings consisting of β -glu multilayers [ 10 ] on an inorganic-oxide particle by leveraging on our demonstrated ability to graft β -glu monolayers. [11][12][13] Our approach (i) is accomplished in a single step and in high yield, (ii) generates uniform porous nanocoatings without the need for catalysts or surfactants, and (iii) offers synthetic tunability of the resulting nanocoating.

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ATRP-mediated continuous assembly of polymers for the preparation of nanoscale films

Cited by 46 publications

References 26 publications

The role of capsule stiffness on cellular processing

The role of capsule stiffness on cellular processing

Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

Single‐Pot Encapsulation of Oxide Particles within a Polysaccharide Multilayer Nanocoating

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