Atroposelective Ir-Catalyzed C–H Borylation of Phthalazine Heterobiaryls
Paul Stehrer,
Anke Spannenberg,
Marko Hapke
Abstract:The atroposelective iridium-catalyzed borylation of menthyloxy-substituted
phthalazine heterobiaryls with diborons is reported. Utilizing [Ir(OMe)(COD)]
2
/2-aminopyridine as a rarely used efficient catalyst system,
the heterobiaryls were selectively borylated in the 2-position of
the carbocycle, exclusively yielding only one of the atropisomers,
depending on the substitution of the phthalazine with (+)-menthyl
or (−)-menthyl moieties. Exemplary further functionalization
of a borylated a… Show more
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