Atropisomerism in bi-1,2,3-triazoles: Detection by 1H NMR using chiral shift reagents and torsional barriers calculations

Santana-Martínez, Ivette; Bautista-Renedo, Joanatan M.; Ayala-Bueno, Sabrina V.; Zavala‐Segovia, Nieves; González‐Rivas, Nelly; Corona‐Becerril, David; Cuevas-Yáñez, Erick

doi:10.1016/j.molstruc.2022.133969

Search citation statements

Order By: Relevance

Paper Sections

Select...

The Copper Catalyzed Azide Alkyne Cycloaddition (Cuaac) and ...1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[29] Noteworthy, the bis-1,2,3-triazoles 22, when properly substituted, exhibit atropoisomerism as detected through a straightforward analysis using Eu(hfc) 3 chiral shift reagent in 1 H-NMR. [32] This atropoisomeric triazoles might be particularly useful as chiral ligands in enantioselective catalysis.…”

Section: The Copper Catalyzed Azide Alkyne Cycloaddition (Cuaac) and ...mentioning

confidence: 97%

Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions

Brunelli,

Russo,

Giustiniano

et al. 2024

Chemistry A European J

View full text Add to dashboard Cite

The particular and unique mechanism of the copper‐catalyzed reaction between azides and alkynes (CuAAC) has not only allowed for the efficient synthesis of 1,2,3‐trisubstituted 1,4‐triazoles in excellent yields and under mild conditions, becoming the quintessential click reaction, but it has also enabled the straightforward formation of a metallocycle intermediate, the copper triazolyl. This, under suitable reaction conditions able to suppress its protonolysis, can be used either for the creation of new bicyclic triazolyl structures or for the generation of novel three or four‐component reactions. The aim of this review is to rationalize and unify all these transformations, which are collectively referred to as “interrupted click reactions”.

show abstract

Section: The Copper Catalyzed Azide Alkyne Cycloaddition (Cuaac) and ...mentioning

confidence: 97%

Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions

Brunelli,

Russo,

Giustiniano

et al. 2024

Chemistry A European J

View full text Add to dashboard Cite

show abstract

Atropisomerism in bi-1,2,3-triazoles: Detection by 1H NMR using chiral shift reagents and torsional barriers calculations

Cited by 1 publication

References 28 publications

Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions

Each Interruption is an Opportunity: Novel Synthetic Strategies Explored Through Interrupted Click Reactions

Contact Info

Product

Resources

About