Atropisomerism and Axial Chirality

Planar Chirality: A Mine for Catalysis and Structure Discovery

“…Asymmetric catalysis is widely recognized as the ideal strategy for the production of enantiomerically enriched compounds [33] . In recent decades, the organic community has made great efforts to develop new efficient asymmetric procedures, mainly devoted to produce molecules with central chirality and, more recently, axial chirality [34] . Meanwhile, planar chirality remains in its infancy and the exploitation of catalysis to induce asymmetry during the formation of planar‐chiral compounds is very uncommon.…”

Engineering of inorganic nanostructures with hierarchy of chiral geometries at multiple scales

“…Axial chirality is a standard geometry of mirror‐asymmetric molecules exemplified by allenes and substituted biphenyls 12 . These molecules do not have a chiral center but an axis of chirality, about which a set of substituents is held in a spatial arrangement that is not superposable on its mirror image.…”

Atroposelective Transfer Hydrogenation of Biaryl Aminals via Dynamic Kinetic Resolution. Synthesis of Axially Chiral Diamines

“…Among the synthetic strategies for the synthesis of axially chiral biaryls, , dynamic kinetic resolution (DKR) of configurationally unstable cyclic biaryl precursors has been exploited with success in several contexts. The “lactone concept” developed by Bringmann and co-workers first exploited the lability of biaryl lactones in transesterification reactions, finding numerous applications in the synthesis of natural products and bioactive substances. , Efficient catalytic variants of this strategy made use of Co-, Ir-, and Cu-catalyzed reductions and a transesterification reaction using a bifunctional thiourea catalyst (Scheme A).…”