Atropine use may lead to post-operative respiratory acidosis in neonates receiving ductal ligation: A retrospective cohort study

Chang, Shu−Tong; Lin, Wen-Li; Weng, Chien‐Hsiang; Wu, Shye-Jao; Tsai, Hsiu‐Ming; Wang, Shwu-Meei; Peng, Chun-Chih; Chang, Jui‐Hsing

doi:10.1016/j.pedneo.2017.04.005

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early experimental and clinical studies have reported that structurally-related tropane alkaloids (such as anisodamine, scopolamine, and atropine) have potential undesirable effects on the cardiovascular and respiratory systems. [13][14][15][16][17][18] Thus, it is necessary to investigate the effects of Ani on cardiorespiratory function systematically. Additionally, although some drugs, such as antibiotics, tricyclic antidepressants, and antifungal agents do not act on the cardiovascular system directly based on their mechanism of action, nonetheless they have been reported to lead to life-threatening adverse effects, and some patients have suffered serious heart damage after taking these drugs in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Liu

Wang

Wan

et al. 2020

DDDT

View full text Add to dashboard Cite

Purpose: Anisodine hydrobromide (Ani) is isolated from the medicinal plant Anisodus tanguticus (Maxim.) Pascher for clinical use. Although considerable research regarding Ani has been reported, the safety profiles of Ani are currently unknown. This study investigated the cardiorespiratory effects of Ani in conscious dogs to provide clinicians a detailed safety profile of Ani on the cardiorespiratory system. Materials and Methods: Using the Latin square design, the study was divided into six phases, where in each phase, six telemetered beagle dogs received one dose of normal saline or sotalol hydrochloride or Ani (0.1, 0.4, 1.6, or 6.4 mg/kg). Electrocardiogram, blood pressure (BP) and respiratory parameters were collected before and after administration for 24 hours. Statistical comparisons were performed at scheduled time-points. Results: The heart rate was significantly increased, PR and QT C V intervals were significantly shortened in Ani 0.4, 1.6, 6.4 mg/kg treatment group after drug administration. Compared with the saline group, a significant increase in heart rate and shortening of PR, QT C V intervals were observed in the Ani 1.6, 6.4 mg/kg treatment groups from 5 min to 4 h time-points. Diastolic and mean BP were significantly increased in Ani 1.6, 6.4 mg/kg from 1 h to 2 h time-points compared to those of the saline control. Accelerated breathing was observed in the first 20 min after Ani 0.4, 1.6, and 6.4 mg/kg treatment, although not statistically significant. Furthermore, no significant differences were observed in any of the corresponding indexes of Ani 0.1 mg/kg treatment group at different time-points compared to those of the saline group. Conclusion: Ani may have adverse effects on the cardio-respiratory systems of dogs at doses above 0.4 mg/kg, whereas Ani 0.1 mg/kg was devoid of potentially deleterious effects on cardiorespiratory function.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Liu

Wang

Wan

et al. 2020

DDDT

View full text Add to dashboard Cite

show abstract

Surgical Treatment of Open Ductus Arteriosus in Premature Infants

Aleksi-Meskhishvili

Kozlov

2018

Russian Journal of Pediatric Surgery

View full text Add to dashboard Cite

The choice of tactics for the treatment of open arterial duct (OAD) in newborns is one of the most controversial and debatable topics in neonatal medicine. There are several approaches in the treatment of OAD in small infants: 1) the prophylactic use of cyclooxygenase inhibitors; 2) treatment on the background of maintenance therapy without the medical and surgical intervention; 3) drug stimulation of the closure of the AOA; 4) surgical intervention. Surgical treatment, which can be done with the aid of the open surgery and thoracoscopy, still plays a leading role. Complications associated directly with the operation are minimal. In this study, we present a review of the literature, including current information on the most frequent complications arising from the surgical treatment of OAD in newborns - damage to the lungs with the development of pneumothorax, damage to the great vessels with circulatory disorders, wound to the left phrenic nerve followed by paresis of the left diaphragm dome, damage to the recurrent nerve with impaired function of the left vocal cords, damage to the thoracic lymphatic duct with the development of chylothorax, damage to the muscles with development of functional scoliosis. Special attention is paid to the prognosis of the course of the disease and the survival rate of low birth weight infants.

show abstract

Atropine use may lead to post-operative respiratory acidosis in neonates receiving ductal ligation: A retrospective cohort study

Abstract: The use of atropine as premedication in general anesthesia for neonatal PDA ligation is associated with higher risk of respiratory acidosis, which worsens with the combined use of ketamine.

Cited by 2 publications

References 19 publications

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Surgical Treatment of Open Ductus Arteriosus in Premature Infants

Contact Info

Product

Resources

About