Abstract:2,5-Hexanedione is a n-hexane metabolite with neurotoxic properties. We have previously demonstrated that acute administration of 2,5-hexanedione causes analgesia in the tail-flick test in rats. In the present investigation, we examined the possible involvement of a cholinergic component in the 2,5-hexanedione-induced antinociception, since literature data indicate that this hexacarbon compound may act as a competitive inhibitor of acetylcholinesterase and that cholinesterase inhibitors are analgesic to rodent… Show more
“…Proposed biomarkers for past exposure to n-hexane are the already mentioned pyrrolidation of proteins or the evaluation of increased acetylcholine esterase release from tissues accompanying 2,5-HD intoxication [12,13].…”
“…Proposed biomarkers for past exposure to n-hexane are the already mentioned pyrrolidation of proteins or the evaluation of increased acetylcholine esterase release from tissues accompanying 2,5-HD intoxication [12,13].…”
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