Atrophyc humeral shaft nonunion treated with teriparatide (rh PTH 1-34): A case report

Systemic Administration of Sclerostin Antibody Enhances Bone Repair in a Critical-Sized Femoral Defect in a Rat Model

“…However, mixed results have been reported with the use of recombinant human PTH (rhPTH) to promote fracture-healing. In a number of case reports and a randomized clinical trial, intermittent rhPTH enhanced fracture repair [37][38][39][40] . However, in a recent randomized clinical trial, rhPTH did not enhance the healing of distal radial fractures 41 .…”

Successful treatment of nonuniting fracture ICNF with Teriparatide in young adult osteopenic male

“…8 Another study showed a patient with delayed union of a humeral shaft fracture healed after 5 months of therapy with teriparatide, without other interventions. 9 Resmini et al described a 79-year-old osteoporotic lady already on teriparatide treatment who sustained a fracture of the left proximal humerus. 10 She was maintained on teriparatide, and radiographic fracture healing occurred rapidly after 25 days which was attributed to teriparatide treatment.…”

The Role of Parathyroid Hormone in Fracture Healing

“…Case reports and case series have been reported and suggest that PTH analogs aid in the treatment of fractures distributed throughout the body. [47][48][49][50][51] Most of these studies have noted the effect of PTH in the context of problem fractures with nonunions or stress fractures. Oteo-Alvaro et al 47 reported the case of a 32-year-old male who sustained a right diaphyseal humeral shaft fracture while skiing.…”

“…[47][48][49][50][51] Most of these studies have noted the effect of PTH in the context of problem fractures with nonunions or stress fractures. Oteo-Alvaro et al 47 reported the case of a 32-year-old male who sustained a right diaphyseal humeral shaft fracture while skiing. Initially, this humeral fracture was treated surgically with intramedullary osteosynthesis consisting of two elastic nails.…”