Atrophy rates accelerate in amnestic mild cognitive impairment

Jack, Clifford R.; Weigand, Stephen D.; Shiung, Maria M.; Przybelski, Scott A.; O’Brien, Peter C.; Gunter, Jeffrey L.; Knopman, David S.; Boeve, Bradley F.; Smith, Glenn E.; Petersen, Ronald C.

doi:10.1212/01.wnl.0000281688.77598.35

Cited by 164 publications

(140 citation statements)

References 61 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…The mean MMSE in ADNI is higher than the studies reported above, as ADNI enrolled at an early disease stage. Atrophy rate in early disease has been reported to be lower and this rate increases with severity [5,[33][34][35]. Another study has reported a lower rate of atrophy than our study; Jack et al reported slow-progressing ADs having a median (interquartile range) atrophy rate of 0.6%/ year (0.7%/year) and fast-progressing patients having an atrophy rate of 1.4%/year (1.1%/year) [10].…”

Section: Discussioncontrasting

confidence: 46%

“…Another study reported an overall mean (SD) atrophy rate in MCI of 0.7%/year (0.7%/year) [11]. One recent paper has also demonstrated that because MCI atrophy rates accelerate in those subjects who convert to AD the calculated rate in converters in any study may therefore be dependent upon proximity to conversion [5]. A further paper has shown that higher whole-brain atrophy rates are associated with an increased risk of converting to AD from MCI [12].…”

Section: Discussionmentioning

confidence: 96%

“…At a group level AD is associated with smaller brain volumes and larger ventricles than healthy age-matched controls, while MCI groups have intermediate volumes [5]. However, there is overlap between these measures due to the natural variation in cerebral volumes, morphology and physiological state at the time of MRI.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Volume changes in Alzheimer’s disease and mild cognitive impairment: cognitive associations

et al. 2009

View full text Add to dashboard Cite

Objective: To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. Material and methods: In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. Results: Brain atrophy rates and ventricular enlargement differed between subject groups (p<0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p<0.0005) and ventricular expansion rates (p=0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. Conclusion: Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers.

show abstract

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Volume changes in Alzheimer’s disease and mild cognitive impairment: cognitive associations

et al. 2009

View full text Add to dashboard Cite

show abstract

“…While for CN, the traditional linear model and quadratic provided similar results, it seems that for AD a quadratic model fits better than a linear model. The nonlinear nature of the atrophy related to AD has recently been studied (Frisoni et al, 2010;Frisoni et al, 2009;Jack et al, 2008). As noticed in (Frisoni et al, 2010), while the majority of studies are based on the linear assumption of the AD progression, brain atrophy during AD is not a linear process.…”

Section: Relationship Between Snipe Grade and Agementioning

confidence: 99%

Simultaneous segmentation and grading of anatomical structures for patient's classification: Application to Alzheimer's disease

et al. 2012

View full text Add to dashboard Cite

“…[5][6][7] We examined longitudinal rates of regional neocortical atrophy over 1 year in 137 healthy controls and 335 individuals at different stages of clinical impairment. Annual atrophy rates were of interest because they have demonstrated high sensitivity to subtle brain changes in AD and may discriminate between diagnostic groups better than baseline brain measures.…”

mentioning

confidence: 99%

Regional rates of neocortical atrophy from normal aging to early Alzheimer disease

McDonald

McEvoy²,

Gharapetian³

et al. 2009

Neurology

268

202

View full text Add to dashboard Cite

Objective: To evaluate the spatial pattern and regional rates of neocortical atrophy from normal aging to early Alzheimer disease (AD). Methods:Longitudinal MRI data were analyzed using high-throughput image analysis procedures for 472 individuals diagnosed as normal, mild cognitive impairment (MCI), or AD. Participants were divided into 4 groups based on Clinical Dementia Rating Sum of Boxes score (CDR-SB). Annual atrophy rates were derived by calculating percent cortical volume loss between baseline and 12-month scans. Repeated-measures analyses of covariance were used to evaluate group differences in atrophy rates across regions as a function of impairment. Planned comparisons were used to evaluate the change in atrophy rates across levels of disease severity. Results:In patients with MCI-CDR-SB 0.5-1, annual atrophy rates were greatest in medial temporal, middle and inferior lateral temporal, inferior parietal, and posterior cingulate. With increased impairment (MCI-CDR-SB 1.5-2.5), atrophy spread to parietal, frontal, and lateral occipital cortex, followed by anterior cingulate cortex. Analysis of regional trajectories revealed increasing rates of atrophy across all neocortical regions with clinical impairment. However, increases in atrophy rates were greater in early disease within medial temporal cortex, whereas increases in atrophy rates were greater at later stages in prefrontal, parietal, posterior temporal, parietal, and cingulate cortex.

show abstract

Atrophy rates accelerate in amnestic mild cognitive impairment

Cited by 164 publications

References 61 publications

Volume changes in Alzheimer’s disease and mild cognitive impairment: cognitive associations

Volume changes in Alzheimer’s disease and mild cognitive impairment: cognitive associations

Simultaneous segmentation and grading of anatomical structures for patient's classification: Application to Alzheimer's disease

Regional rates of neocortical atrophy from normal aging to early Alzheimer disease

Contact Info

Product

Resources

About