Atrophy in Alzheimer’s Disease and Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies

Chapleau, Marianne; Aldebert, Joséphine; Montembeault, Maxime; Brambati, Simona Maria

doi:10.3233/jad-160382

Cited by 62 publications

(46 citation statements)

References 110 publications

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“…The primary reason why we conducted VBM analyses is the limited available data regarding structural brain-behavior correlations with svPPA patients. For a meta-analysis of studies on the pattern of atrophy in the svPPA, see Chapleau et al (2016). Behaviorally, we hypothesize that, as compared to the healthy participants, the svPPA group will have a lower reading accuracy for exception words and a greater number of regularization errors (Wilson et al, 2012; Woollams et al, 2014; Boukadi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading

et al. 2017

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The anterior temporal lobes (ATLs) have been consistently associated with semantic processing which, in turn, has a key role in reading aloud single words. This study aimed to investigate (1) the reading abilities in patients with the semantic variant of primary progressive aphasia (svPPA), and (2) the relationship between gray matter (GM) volume of the left ATL and word reading performance using voxel-based morphometry (VBM). Three groups of participants (svPPA, Alzheimer’s Disease, AD and healthy elderly adults) performed a reading task with exception words, regular words and pseudowords, along with a structural magnetic resonance imaging scan. For exception words, the svPPA group had a lower accuracy and a greater number of regularization errors as compared to the control groups of healthy participants and AD patients. Similarly, for regular words, svPPA patients had a lower accuracy in comparison with AD patients, and a greater number of errors related to complex orthography-to-phonology mappings (OPM) in comparison to both control groups. VBM analyses revealed that GM volume of the left ATL was associated with the number of regularization errors. Also, GM volume of the left lateral ATL was associated with the number of errors with complex OPM during regular word reading. Our results suggest that the left ATL might play a role in the reading of exception words, in accordance with its role in semantic processing. Results further support the involvement of the left lateral ATL in combinatorial processes, including the integration of semantic and phonological information, for both exception and regular words.

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Section: Introductionmentioning

confidence: 99%

The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading

et al. 2017

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“…Four millimeter radius spheres centered on the coordinates −26 −6 −22 (left aHip), 26 −6 −22 (right Hp), −28 −35 3 (left pHip) and 28 –35 3 (right pHip) were used as seed regions. The coordinates of the spheres’ centers were based on our previous meta‐analysis, in which we pooled together all the voxel‐based morphometry studies investigating gray matter atrophy in patients with svPPA and Alzheimer's disease (Chapleau et al, ). The coordinate in the aHip sphere's center represents the peak coordinate of hippocampal atrophy in svPPA compared to controls.…”

Section: Methodsmentioning

confidence: 99%

“…The study included 12 patients with a clinical diagnosis of svPPA (Gorno-Tempini et al, 2011;3 women, 9 men; mean age of 65.9 ± 10.8), and 11 cognitively unimpaired CTRLs (4 women, 7 men; mean age of 65.7 ± 8.1) matched for age, sex, and education. SvPPA coordinates of the spheres' centers were based on our previous metaanalysis, in which we pooled together all the voxel-based morphometry studies investigating gray matter atrophy in patients with svPPA and Alzheimer's disease (Chapleau et al, 2016). The coordinate in the aHip sphere's center represents the peak coordinate of hippocampal atrophy in svPPA compared to controls.…”

Section: Methodsmentioning

confidence: 99%

“…The semantic variant of primary progressive aphasia (svPPA) is a neurodegenerative disease characterized by progressive multimodal loss of semantic knowledge (Gorno‐Tempini et al, ; Hodges, Patterson, Oxbury, & Funnell, ; Mesulam, ; Snowden, Goulding, & Neary, ), mainly targeting the anterior temporal regions of the left hemisphere. Early atrophy of the hippocampus, bilaterally but predominantly in the left side, has been recently reported as one of the early anatomical characteristics of svPPA (Chapleau, Aldebert, Montembeault, & Brambati, ).…”

Section: Introductionmentioning

confidence: 98%

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The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting‐state fcMRI study

et al. 2019

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The goal of the study was to determine whether the semantic variant of primary progressive aphasia (svPPA) affects the intrinsic connectivity network anchored to left and right anterior hippocampus, but spares the posterior hippocampus. A resting‐state functional connectivity MRI (rs‐fcMRI) study was conducted in a group of patients with svPPA and in controls, using a seed‐to‐voxel approach. In comparison to controls, massively reduced connectivity was found in the anterior hippocampus, mainly the left one, for svPPA patients but not in the left or right posterior hippocampus. In svPPA, the anterior hippocampus showed reduced functional connectivity with regions implicated in the semantic memory network. Significant correlation was also found between the functional connectivity strength of the left anterior hippocampus and the ventromedial cortex, and performance in semantic tasks. These findings indicate that the functional disconnection of the anterior hippocampus may be a promising in vivo biomarker of svPPA and illustrate the role of this hippocampal subregion in the semantic memory system.

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“…Various neurodegenerative diseases, such as Alzheimer's disease [120] and neuropsychiatric diseases, such as depression [121,122], anxiety disorder [123], post-traumatic stress disorder [124] and schizophrenia [125] lead to structural shrinkage of the hippocampus. In this context, several studies have pointed the positive impact of Hatha Yoga on symptoms in neurological disorders [13,[126][127][128][129].…”

Section: Clinical Contributionmentioning

confidence: 99%

10-Week Hatha Yoga Increases Right Hippocampal Density Compared to Active and Passive Control Groups: A Controlled Structural cMRI Study

Garner¹,

Reith²,

Krick³

2019

J Neuroimaging Psychiatry Neurol

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Background:The current study was designed to evaluate potential Yoga specific changes of brain structure in comparison with an active sport group and a passive control group. Materials and Methods:We conducted a longitudinal structural MRI study to investigate changes in gray matter (GM) density following a Yoga intervention. In order to check the repeatability of the results two data acquisition periods (cohorts) with the same study design were done. Yoga naive subjects (n = 19/n = 20) received a Yoga intervention once a week for 75 minutes over a period of 10 weeks. Control groups included active sport subjects (n = 10/n = 22) and passive subjects (n = 17/n = 14). All participants could choose their group assignment by their own preference. A longitudinal and group comparison was done by voxelbased-morphometric analyses before and after the intervention. In addition, blood pressure was taken before and after the study period as a controlling instrument. Finally, the results of the two cohorts were reported into a comprising data set for a general conclusion on Yoga effects. Results:Initially, hippocampal GM density in the Yoga group was significantly lower than in both control groups already before the intervention. It was equally and independently present in both cohorts. The longitudinal MRI measurements showed a significant increase in the right hippocampal GM density as a specific effect of the Hatha Yoga intervention. Coincidentally, the blood pressure measurement detected a significant reduction in both systolic and diastolic blood pressure in the Yoga group but not in the sport or passive group. Conclusions:Various neurodegenerative and neuropsychiatric diseases as well as long lasting stress lead to structural shrinkage of the hippocampal GM. In contrast, stress reduction was shown to be associated with an increase in the hippocampal GM density. The Yoga specific effect in this study can be considered as positive impact on both stress management and its underlying neural structure. These effects have been already proven in prevention and therapy of neurodegenerative and neuropsychiatric diseases. The Yoga-induced stress reduction can be furthermore supported by the findings of blood pressure reduction. Blood pressure is well known as an indirect indicator for stress reduction. Since the GM density was detected lower in the two Yoga cohorts twice compared to both control groups, one may postulate a pre-existing but unconscious higher stress vulnerability when voluntarily deciding for the Yoga intervention.

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Atrophy in Alzheimer’s Disease and Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies

Cited by 62 publications

References 110 publications

The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading

The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading

The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting‐state fcMRI study

10-Week Hatha Yoga Increases Right Hippocampal Density Compared to Active and Passive Control Groups: A Controlled Structural cMRI Study

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