Atrophic pigmented dermatofibrosarcoma protuberans misdiagnosed as hyperpigmentation

Lin, Pingping; Yang, Zhiyong; Tu, Ping; Li, Hang

doi:10.25259/ijdvl_713_20

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…Moreover, years after the initial diagnosis, a minority of nearly 6% can invade distant organs such as the lungs [16]. However, one study reported 15% lung metastasis in DFSP cases in correlation with other forms of high-grade sarcomas [6,13,[17][18][19]. Age and gender are not risk factors for DFSP and its recurrence.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…4 Sections of ill-defined mesenchymal neoplasm involving papillary and reticular dermis sign of malignancy in DFSP lesions. It is advised that such patients should be referred to a cancer center with staff members experienced in cases of lesions with suspected sarcoma, for the purpose not only of preoperative microscopic study of the lesions, but also their treatment [8,18,20]. As the DFSP grows to late stages, it can be ulcerative, painful, and bleeding, in contrast to a low-grade lesion [16].…”

Section: Clinical Featuresmentioning

confidence: 99%

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Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

et al. 2023

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Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. Case presentation Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery. Conclusion Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

et al. 2023

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“…A 2020 case out of Bejing, China, by Lin et al, documented a case of DFSP misdiagnosed for 10 years as post-inflammatory hyperpigmentation [ 12 ]. The patient was a 33-year-old female with a 1.6 x 1.3 cm erythematous-to-bluish, ill-defined, depressed plaque on the left upper back.…”

Section: Discussionmentioning

confidence: 99%

A 73-Year-Old Female Diagnosed With Dermatofibrosarcoma Protuberans in the Primary Care Setting: A Case Report and Literature Review of Misdiagnosed Cases

Guerra,

Faraj,

Ainsley

et al. 2024

Cureus

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Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing, malignant tumor in the dermis and subcutaneous fat diagnosed by pathological and immunohistochemical examinations. This case report provides the dermatological findings of a 73-year-old woman with DFSP who presented to a primary care clinic with a longstanding nodular lesion on her left upper thigh. Dermatological examination showed a solitary, skin-colored violaceous/hyperpigmented nodule on the superior anteromedial portion of the left thigh. A punch biopsy revealed spindle cell proliferation, and diffuse CD34 positivity, confirming the diagnosis of DFSP. A dermatology referral was placed for further management and complete surgical excision. Patient underwent wide local excision (WLE) and has no recurrence to date. Unfortunately, DFSP is commonly misdiagnosed before skin biopsy which delays treatment. This case is significant because DFSP is not often diagnosed accurately outside the dermatology specialty and serves as a reminder to practitioners to use biopsies during the diagnostic process of skin findings to prevent the delay in management.

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“…Delayed diagnosis and misdiagnosis are common. 5/8 cases of atrophic pigmented DFSP were misdiagnosed as benign lesions, including nevus of Ota, postinflammatory hyperpigmentation, hemangioma, and lipoatrophy ( 20 , 55 , 61 ). A high index of suspicion and a broad differential diagnosis by dermatologists is necessary.…”

Section: Discussionmentioning

confidence: 99%

Atrophic dermatofibrosarcoma protuberans: Two case reports and literature review

Chen

Nie

et al. 2023

Front. Oncol.

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Dermatofibrosarcoma protuberans is a rare, locally aggressive, slowly growing cutaneous fibroblastic sarcoma with a high recurrence rate and low metastatic potential. Atrophic dermatofibrosarcoma protuberans is a rare variant usually presents as atrophic plaques, easily neglected and misdiagnosed as benign lesions by patients and dermatologists. Here we report two cases of atrophic dermatofibrosarcoma protuberans, one of which was accompanied by pigment, and review other cases have been reported in the literature. Understanding the most up-to-date literature and early identification of these dermatofibrosarcoma protuberans variants can help clinicians avoid delayed diagnosis and improve prognosis.

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Atrophic pigmented dermatofibrosarcoma protuberans misdiagnosed as hyperpigmentation

Cited by 6 publications

References 11 publications

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

A 73-Year-Old Female Diagnosed With Dermatofibrosarcoma Protuberans in the Primary Care Setting: A Case Report and Literature Review of Misdiagnosed Cases

Atrophic dermatofibrosarcoma protuberans: Two case reports and literature review

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