Atrophic Gastritis and Gastric Cancer Risk amongst Diabetes Mellitus Type 2 Subjects and Controls in Yaounde Cameroon Using a Panel of Serum Biomarkers (PGI, G-17)

Ebule, IA; Djune, Fak; Njeambosay, BA; Befolo, Mhdm; Nkayo, M; Metaghue, G; Majuikouo, L; Tanni, B; Heugueu, C; Feuatsapk, C; Noah, ND; Paloheimo, Lea; Syrjänen, Kari

doi:10.23937/2469-584x/1510052

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The multivariate regression analysis showed that cardiovascular disease and respiratory disease lost statistical significance in patients that were 65 years of age or older, implying that age > 65 years was a confounding factor. Diabetes mellitus is no longer significantly correlated with anemia in the presence of premalignant gastric lesions, with other studies demonstrating different results [28], [29].…”

Section: Discussionmentioning

confidence: 77%

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Munteanu,

Cozac-Szőke,

Mocan

et al. 2023

Acta Marisiensis - Seria Medica

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Objective: The objective of the present study is to clarify the value of clinic, endoscopic, and histologic variables that may predict anemia in patients performing esophagogastroduodenoscopy for gastrointestinal complaints in the absence of bleeding signs or lower digestive disease. Methods: This study included 654 patients referred for endoscopy that were divided based on biological parameters performed in the same day in the study group (306 patients diagnosed with anemia) and the control group (348 patients without anemia). Results: Anemia is frequent in elderly patients, especially in the presence of premalignant gastric lesions, and it is associated with multiple comorbidities. In two multivariate regression models antivitamin K oral anticoagulants were found to be independently associated with anemia (p = 0.01), but not with antiplatelet therapy, or with non-antivitamin K anticoagulants. Multiple regression models support that epigastric pain and heartburn are inversely associated with anemia, while weight loss remained an independent predictor for simultaneous anemia and premalignant lesions. Non-infectious chronic gastritis (p<0.001) is an independent predictor for anemia and premalignant gastric lesions, increasing the odds of anemia by 2.2 times, while reactive gastropathy is inversely associated. Gastric erosions and ulcer remained independent predictors for concomitant anemia and premalignant lesions. Conclusions: Chronic inactive gastritis and premalignant gastric histologic lesions are predictors for anemia in endoscopic population, while active H. pylori infection is not. Dyspeptic symptoms, epigastric pain (p<0.001,OR 0.2-0.5) and heartburn (p<0.001,OR 0.07-0.3) are inversely associated with anemia alone or associated with premalignant gastric lesions.

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Section: Discussionmentioning

confidence: 77%

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Munteanu,

Cozac-Szőke,

Mocan

et al. 2023

Acta Marisiensis - Seria Medica

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“…Patients with diabetes were found to be at higher risk for developing peptic ulcers [5]. In addition to this, a case-control study revealed that diabetic patients had a higher propensity to atrophic corpus gastritis, a significant risk factor for distal gastric cancer [6]. Therefore, the evidences raised the question whether anti-diabetic agents had protective effects against gastric diseases, especially gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Comparing the risks of new-onset gastric cancer or gastric diseases in type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1A: a population-based cohort study

Chou

Chauhan

Chung³

et al. 2023

Preprint

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Objective: To compare the risks of gastric cancer and other gastric diseases upon exposed to sodium-glucose cotransporter 2 inhibitors (SGLT2I), dipeptidyl peptidase-4 inhibitors (DPP4I) and glucagon-like peptide-1 receptor agonists (GLP1A). Design: This was a retrospective population-based cohort study of prospectively recorded data on type-2 diabetes mellitus (T2DM) patients prescribed either SGLT2I or DPP4I between January 1st 2015 and December 31st 2020 from Hong Kong. The primary outcome was new-onset gastric cancer, peptic ulcer (PU), acute gastritis, non-acute gastritis, and gastroesophageal reflux disease (GERD). Propensity score matching (1:1 ratio) using the nearest neighbour search was performed and multivariable Cox regression was carried out. A three-arm analysis including the GLP1A cohort was subsequently conducted. Results: A total of 62858 T2DM patients (median age: 62.2 years old [SD: 12.8]; 55.93% males; SGLT2I: n=23442; DPP4I: n=39416) were included. After matching, the incidence of gastric cancer was significantly lower in SGLT2I users (Incidence rate, IR: 0.32; 95% confidence interval, CI: 0.23-0.43) than DPP4I users (IR: 1.22; CI: 1.03-1.42). SGLT2I use was associated with lower risks of gastric cancer (HR: 0.30; 95% CI: 0.19-0.48) after adjusting for significant covariates compared to DPP4I use. SGLT2 use was also associated with lower risks of PU, acute gastritis, non-acute gastritis, and GERD (all p<0.05). The three-arm analysis demonstrated higher risks of gastric cancer and GERD in GLP1A than in SGLT2I. Conclusions: SGLT2I was associated with lower risks of new-onset gastric cancer, PU, acute gastritis, non-acute gastritis, and GERD after matching and adjustments compared to DPP4I.

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Atrophic Gastritis and Gastric Cancer Risk amongst Diabetes Mellitus Type 2 Subjects and Controls in Yaounde Cameroon Using a Panel of Serum Biomarkers (PGI, G-17)

Cited by 2 publications

References 15 publications

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Comparing the risks of new-onset gastric cancer or gastric diseases in type 2 diabetes mellitus patients exposed to SGLT2I, DPP4I or GLP1A: a population-based cohort study

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