Atrophic Body Gastritis: Distinct Features Associated with <i>Helicobacter pylori</i> Infection

Annibale, Bruno; Marignani, Massimo; Azzoni, Cinzia; D’Ambra, G.; Caruana, Pietro; D’Adda, Tiziana; Fave, Gianfranco Delle; Bordi, Cesare

doi:10.1111/j.1523-5378.1997.tb00060.x

Cited by 90 publications

(121 citation statements)

References 27 publications

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“…Criteria for the diagnosis of ABG: The diagnosis of ABG was based on the presence of fasting gastrin above upper normal values, and histological confirmation of gastric body mucosal atrophy, as previously described [24,25] . Briefly, all patients underwent gastroscopy with standardized biopsy sampling from the antrum (n = 3), body (n = 3) for conventional histopathological examination [24,25] .…”

Section: Patientsmentioning

confidence: 99%

“…Briefly, all patients underwent gastroscopy with standardized biopsy sampling from the antrum (n = 3), body (n = 3) for conventional histopathological examination [24,25] . The degree of gastritis was assessed according to the updated Sydney System [26] .…”

Section: Patientsmentioning

confidence: 99%

“…The degree of gastritis was assessed according to the updated Sydney System [26] . Atrophy of the body and antral mucosa was defined as focal or complete replacement of oxyntic or pyloric glands by metaplastic pyloric or intestinal glands, respectively [24,25] . Furthermore, all patients underwent serological studies: fasting gastrin levels were evaluated by means of a specific radioimmunoassay (RIA) using polyclonal antibody No.…”

Section: Patientsmentioning

confidence: 99%

“…Furthermore, all patients underwent serological studies: fasting gastrin levels were evaluated by means of a specific radioimmunoassay (RIA) using polyclonal antibody No. 4562 [24,25] . PepsinogenⅠlevels were measured using a commercial RIA kit (Pepsik, Sorin, Saluggia, Italy) [25] .…”

Section: Patientsmentioning

confidence: 99%

“…PepsinogenⅠlevels were measured using a commercial RIA kit (Pepsik, Sorin, Saluggia, Italy) [25] . Antibodies against anti-parietal cells were assayed using a commercial kit (Autostat, Cogent Diagnostic Ltd, Edinburgh, UK) [24,25] .…”

Section: Patientsmentioning

confidence: 99%

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Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Lahner¹,

Intraligi²,

Buscema³

et al. 2008

WJG

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AIM:To investigate the role of artificial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS:A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artificial neural networks (ANNs) using a data optimisation procedure (standard ANNs, T&T-IS protocol, TWIST protocol). The target variable was the presence of thyroid disease. RESULTS:Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specificity of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy, sensitivity and specificity of 74.7% and 75.8%, 78.8% and 81.8%, and 70.5% and 69.9%, respectively. The increase of sensitivity of the TWIST protocol was statistically significant compared to T&T-IS. CONCLUSION:This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

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Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

See 3 more Smart Citations

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Lahner¹,

Intraligi²,

Buscema³

et al. 2008

WJG

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Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

Centanni¹,

Marignani²,

Gargano³

et al. 1999

Arch Intern Med

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155

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Endocrine cell growths in atrophic body gastritis. Critical evaluation of a histological classification

et al. 1997

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The aim of the present study was to evaluate the correspondence of the classification of non‐antral endocrine cell growths proposed by Solcia and co‐workers with clinical features and non‐endocrine mucosal changes. For this purpose, 94 cases of newly diagnosed atrophic body gastritis were investigated using endoscopic biopsies and compared with 18 control subjects. The patients were subdivided into the following four groups according to the most severe pattern of endocrine cell proliferation found in the body mucosa, as shown by chromogranin A immunostaining: group 1, normal pattern (7 cases, 7·5 per cent); group 2, simple hyperplasia (6 cases, 6·5 per cent); group 3, linear hyperplasia (24 cases, 25·8 per cent); group 4; micronodular hyperplasia (56 cases, 60·2 per cent). Adenomatoid hyperplasia was found in only one case, thus precluding further analysis. Patients in groups 1 and 2 had lower acid secretion, higher gastrin level, and higher mean scores in all histopathological variables of chronic gastritis considered by the Sydney system when compared with controls, but did not differ among them in any parameter investigated. When compared with groups 1 and 2, patients of groups 3 and 4 showed higher values of circulating gastrin, higher scores of glandular atrophy, and lower values of acid secretion and of mononuclear and neutrophil inflammatory cell infiltration. Moreover, group 4 patients differed significantly from those of group 3 in their higher gastrin levels and atrophy scores, and lower scores of neutrophil cell infiltration. On the basis of these results, it is proposed that for practical purposes the normal and the simple hyperplasia patterns may be incorporated into a single group. It is concluded that this classification in its simplified form, based on a qualitative histological approach, shows clinical relevance without the need to perform expensive, time‐consuming morphometric evaluations. © 1997 John Wiley & Sons, Ltd.

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Atrophic Body Gastritis: Distinct Features Associated with Helicobacter pylori Infection

Abstract: Active H. pylori infection, a potential cause of oxyntic gland atrophy, is found in one-fourth of patients with newly diagnosed atrophic body gastritis.

Cited by 90 publications

References 27 publications

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease

Endocrine cell growths in atrophic body gastritis. Critical evaluation of a histological classification

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