Atriocaval Mesothelioma in a Male Sprague-Dawley Rat

Peano, Sergio; Conz, Angelo; Carbonatto, Michela; Goldstein, Jed; Nyska, Abraham

doi:10.1177/019262339802600516

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…Dual immunoreactivity for cytokeratin (epithelial marker) and vimentin (mesenchymal marker) has been reported for some atriocaval mesotheliomas (Alison et al , 1987, Goodall, Christie and Hurley, 1975, Chandra et al , 1993). However, in a previously reported atriocaval mesothelioma in a Sprague-Dawley rat and in the current case, the tumor cells exhibited immunoreactivity for cytokeratin only (Peano et al , 1998). …”

Section: Introductioncontrasting

confidence: 54%

“…It was also reported with lower incidences in the Fischer 344 (F344) (Alison et al , 1987), and Sprague-Dawley rats (Peano et al , 1998). Mesothelioma in the heart region may involve pericardial, epicardial and atriocaval locations.…”

Section: Introductionmentioning

confidence: 89%

“…Atriocaval mesothelioma is a rare heart neoplasm with a significantly high incidence in the inbred NZR/Gd male rat compared to other rat strains (Goodal, Christie, and Hurley 1975;Goodall and Doesburg 1981). It was also reported with lower incidences in the Fischer 344 (F344; Alison et al 1987) and SD rats (Peano et al 1998). Mesotheliomas in the heart region may involve pericardial, epicardial, and atriocaval locations.…”

Section: Straight From the Heartmentioning

confidence: 99%

“…Morphological features include glandular structures lined by nonciliated cuboidal to columnar epithelium supported by a fine fibrovascular stroma admixed with cellular debris, acinar structures filled with eosinophilic amorphous secretory material, extravasated erythrocytes (hemorrhage), hemoglobin crystals, and frequent invasion of the adjacent cardiac musculature (Alison et al , 1987, Goodall, Christie and Hurley, 1975, Goodall and Doesburg, 1981, Peano et al, 1998). Dual immunoreactivity for cytokeratin (epithelial marker) and vimentin (mesenchymal marker) has been reported for some atriocaval mesotheliomas (Alison et al , 1987, Goodall, Christie and Hurley, 1975, Chandra et al , 1993).…”

Section: Introductionmentioning

confidence: 99%

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Proceedings of the 2017 National Toxicology Program Satellite Symposium

Elmore

Aeffner

Bangari³

et al. 2017

Toxicol Pathol

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The 2017 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Montreal, Quebec, Canada, at the Society of Toxicologic Pathology's (STP) 36th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers' talks, along with select images that were used by the audience for voting and discussion. Various lesions and other topics covered during the symposium included renal papillary degeneration in perinatally-exposed animals; an atriocaval mesothelioma; an unusual presentation of an alveolar bronchiolar carcinoma; a paraganglioma of the Organ of Zuckerkandl, also called an extra adrenal pheochromocytoma; the use of human muscle samples to illustrate the challenges of manual scoring of fluorescent staining; intertubular spermatocytic seminomas; medical device pathology assessment and discussion of the approval process; collagen induced arthritis; incisor denticles; ameloblast degeneration and poorly mineralized enamel matrix; connective tissue paragangliomas; microcystin LR toxicity; perivascular mast cells in the forebrain thalamus unrelated to treatment; and two cases that provided a review of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) bone nomenclature and recommended application of the terminology in routine nonclinical toxicity studies.

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Section: Introductioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 89%

Section: Straight From the Heartmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proceedings of the 2017 National Toxicology Program Satellite Symposium

Elmore

Aeffner

Bangari³

et al. 2017

Toxicol Pathol

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“…None of these histological features were noted in the renal tumor and peritoneal nodules. Additionally, peritoneal mesotheliomas are rarely reported in Sprague Dawley rats but occasionally this neoplasm has described within the thoracic cavity 21 , 22 , 23 , 24 . Based on the World Health Organization classification of mesotheliomas in humans, the nature of this tumor is confirmed using a variety of immunohistochemical markers, including pancytokeratin, vimentin, podoplanin, and calretinin 25 .…”

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confidence: 99%

Anaplastic nephroblastoma with peritoneal metastasis in an adult female Sprague Dawley rat

et al. 2020

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Spontaneous nephroblastomas are uncommon tumors of laboratory rats. This report describes a spontaneous nephroblastoma with peritoneal metastasis in an 11-month-old, female Sprague Dawley rat. The rat was part of a breeding program and presented 15 days post parturition with clinical signs including tachypnea, dyspnea and abdominal distension. At necropsy, the right kidney was markedly enlarged by an expansile pale-tan to white multinodular mass with extension into the retroperitoneal space, with multifocal variably sized cystic nodules involving the mesentery, and surface of pancreas, liver, uterus, and ovarian bursa. The rat also had severe bicavitary effusion. Histologically, the renal parenchyma of the affected kidney was replaced by a moderately cellular, poorly-demarcated, nonencapsulated, multilobulated mass that appeared to compress the adjacent renal outer medulla and cortex. Three distinct neoplastic cell populations were identified in this renal tumor: epithelial cells (convoluted and dilated tubules / rare primitive glomeruloid structures), mesenchymal (neoplastic spindle cells in connective tissue), and blastemal cells (primitive neoplastic cells). The extrarenal nodular masses were predominantly composed of neoplastic mesenchymal and pleomorphic blastemal cells. Immunohistochemically, neoplastic epithelial cells in the renal mass were positive for pancytokeratin, and blastemal cells in both renal and extrarenal masses were positive for Wilms tumor 1 protein (WT1) and vimentin. Neoplastic mesenchymal elements in both renal and extrarenal masses were positive for vimentin. The neoplasm was negative for chromogranin A and S100. The tumor was classified as an anaplastic nephroblastoma with metastasis to the mesentery and peritoneal organs.

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