Atrial Septal Defect with Mitral Stenosis in a Woman of 81

Abstract

SummaryFour patients suffering from virilism due to adrenocortical hyperplasia were treated with cortisone, hydrocortisone acetate, prednisone, or prednisolone for periods ranging from six to eighteen months. Oral cortisone was effective in reducing to normal the 17-ketosteroid excretion in the two younger patients, aged 31 and 16 years, but was ineffective in the two older patients, aged 19 and 20 years.Prednisone and prednisolone were the most active in depressing the 17-ketosteroid levels, prednisone being about five times more potent in this respect than oral cortisone and having from two-thirds to three-quarters of the activity of prednisolone.Hydrocortisone acetate injected intramuscularly weekly or fortnightly was also effective.Growth of excess hair was retarded to some extent; acne disappeared in three patients in whom it was present; and menstruation was established in one patient with secondary amenorrhoea.We are indebted to Ciba Laboratories Ltd. for supplies of prednisone (" ultracorten ").

Lutembacher's Syndrome - A Case Report

“…Survival to advanced age has also been reported 12 . In one instance an 81-yearold woman experienced no symptoms related to her heart disease until she reached 75 years of age 12 .…”

“…Planimetry and the Doppler continuity equation methods yield an accurate mitral valve area in the Lutembacher syndrome 12,13 . The experience with transcatheter treatment of the Lutembacher syndrome is small 2,3,9, 14-17 .…”

Trans-catheter Treatment of Lutembacher Syndrome -A Case Report

“…7 Survival to advanced age has also been reported in another instance; an 81 years old woman experienced no symptoms related to her heart disease until she reached 75 years of age. 13 These favorable reports, however, should not obscure the fact that the long-term natural history of ASD is unfavorably influenced by MS, which augments the left to right shunt and predisposes to atrial fibrillation and right ventricular failure. 14 So, if patient is diagnosed at late stage, pulmonary hypertension and heart failure develops and the prognosis is bad.…”

Lutembacher's syndrome: a study of 3 cases

“…1 In one instance in an 81 year old experienced no symptoms related to heart disease until she reached 75 years of age. 4 The hemodynamic effects of this syndrome are a result of the interplay between the relative effects of atrial septal defect and mitral stenosis. Mitral stenosis augments the left to right shunt through the ASD.…”