Atrial receptors and renal function in conscious dogs

Goetz, K R; As, Hermreck; Slick, GL; Starke, HS

doi:10.1152/ajplegacy.1970.219.5.1417

Cited by 42 publications

(14 citation statements)

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“…The current investigations provide a unique model that is capable of testing the alternative mechanism of atrial stretch versus atrial pressure in regulating ANF release. Employing a modification of the model of tamponade used by Goetz et al 10 to examine the role of atrial transmural pressure in the activation of atrial receptors, the present studies confirm the hypothesis that increased atrial transmural pressure and associated atrial stretch increase ANF. In contrast, an increase in atrial cavitary pressure produced by tamponade without an associated increase in atrial transmural pressure was not associated with ANF release.…”

Section: Discussionsupporting

confidence: 83%

“…Goetz and colleagues 10 reported that alterations in atrial transmural pressure, produced by atrial tamponade, may significantly influence atrial receptors and modulate renal function. These previous studies were performed prior to the recognition of the atrial endocrine system and, hence, the influence of intra-atrial versus transmural pressure on ANF release was not investigated.…”

Section: Deitzmentioning

confidence: 99%

See 1 more Smart Citation

Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor.

Edwards

Zimmerman

Schwab

et al. 1988

Circulation Research

451

161

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The current studies were designed to investigate the mechanisms in the intact anesthetized dog that control the release of atrial natriuretic factor (ANF). In vitro, mechanical stretch of atrial tissue produces an increased release of ANF. In vivo, changes in atrial pressure correlate positively with circulating ANF levels. The present investigations used 6 open-chest anesthetized dogs to evaluate the role of atrial pressure versus atrial stretch, the latter determined by atrial transmural pressure, in the release of ANF. In a paired design, animals underwent cardiac tamponade followed by constriction of the aorta and pulmonary artery. Tamponade produces a balanced increase in intra-atrial and pericardial pressures. Thus, despite an elevated atrial pressure, there is no increase in transmural pressure producing atrial stretch. Great artery constriction increases intra-atrial but not pericardial pressure, resulting in an increase in atrial transmural pressure and atrial stretch. Cardiac tamponade increased right atrial pressure (0.8 +/- 0.3 to G.6 +/- 0.6 mm Hg, p less than 0.001) and pulmonary capillary wedge pressure (3.7 +/- 0.6 to 8.8 +/- 0.6 mm Hg, P less than 0.001). Constriction of the aorta and pulmonary artery also increased right atrial pressure (1.5 +/- 0.8 to 6.3 +/- 0.8 mm Hg, p less than 0.05) and pulmonary capillary wedge pressure (4.6 +/- 0.3 to 7.8 +/- 1.0 mm Hg, p less than 0.05). Atrial transmural pressure increased only during great artery constriction.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 83%

Section: Deitzmentioning

confidence: 99%

Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor.

Edwards

Zimmerman

Schwab

et al. 1988

Circulation Research

451

161

View full text Add to dashboard Cite

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“…Closure of an A-V fistula could be analyzed similarly. If AUN causes only trivial changes in right-sided cardiac pressures, as has been reported to be the case on closure of an A-V fistula (16,17), then antinatriuretic stimuli arising from activation of right atrial receptors would be minimal or absent (19)(20)(21). A further parallel between these two maneuvers is the observation of decreased RPF on closure of an A-V fistula (22).…”

Section: Resultsmentioning

confidence: 93%

Role of Hemodynamic Changes in the Increased Cation Excretion after Acute Unilateral Nephrectomy in the Anesthetized Dog

Humphreys¹,

Ayus²

1978

J. Clin. Invest.

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A B S T R A C T Studies were carried out in anesthetized dogs to characterize the increase in cation excretion which occurs after acute unilateral nephrectomy (AUN). 60 min after AUN, cation excretion had increased from 31.5±2.7 to 66.3±12.0 ueq/min (P < 0.005) and fractional cation excretion had increased from 0.56±0.05 to 1.03±0.14% (P < 0.005), as the glomerular filtration rate was unchanged and renal blood flow fell. The increased cation excretion was accompanied by an increase in fractional phosphate excretion, no change in chloride excretion, and a fall in renin secretion. These alterations in renal function were associated with marked changes in systemic hemodynamics: cardiac output fell from 2.52±0.24 to 1.85+0.16 liters/min (P < 0.001), as diastolic pressure rose without an overall increase in mean arterial pressure, and heart rate fell.To assess the importance of these hemodynamic changes in the renal response, AUN in a separate group of dogs was accompanied by the simultaneous opening of a surgically created femoral artery-to-vein fistula at flow matching the blood flow to the removed kidney. When this was done, no alterations in systemic or renal hemodynamics were observed, and cation excretion did not differ from control. Subsequent closure of the fistula then caused a fall in cardiac output from 2.15±0.25 to 1.77±0.20 liters/min (P < 0.05), and an increase in cation excretion from 34.6±9.5 to This work was presented in part at

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“…Expansion of the extracellular fluid volume fails to elicit an increase in urine flow when atrial stretch is prevented (2). Conversely, inflation of a balloon within the right atrium, even in the absence of extracellular fluid volume expansion, results in enhanced urine flow and salt excretion (3), and natriuresis and diuresis frequently accompany paroxysmal atrial tachyarrhythmias (4,5).…”

Section: Introductionmentioning

confidence: 99%