For a long time, the study of heart failure focused on single heart chamber
disease. There is, instead, growing attention on the interplay between the atria
and the ventricles during the cardiac cycle and on the consequences of an altered
chamber coupling on global heart performance and heart failure. This review aimed
to explore the principles of atrioventricular (AV) function and coupling of the
left heart and the consequences that their disruption could have in several
diseases. Furthermore, we will examine echocardiographic tips for analyzing the
chamber function and the AV coupling. Finally, we will explore the most recent
pharmacological acquisitions and the device therapies we have for use.