Atrial natriuretic peptide vs.<scp>N</scp>‐terminal‐pro‐atrial natriuretic peptide for the detection of left atrial dilatation in horses

Vekens, Nicky Van Der; Decloedt, Annelies; Clercq, Dominique De; Ven, S.; Sys, Stanislas U.; Loon, Gunther van

doi:10.1111/evj.12362

Cited by 10 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasonography revealed moderate mitral valve regurgitation (MR) with a slightly dilated left atrium (LA) ( Table 1). The LA/Ao end-systolic diameter ratio was increased to 1.32 (reference value: < 1.25) (Van der Vekens et al, 2016).…”

Section: Case Historymentioning

confidence: 91%

Feochromocytoma bij een paard met polymorfe ventriculaire tachycardie

Dufourni¹,

Clercq²,

Vera³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

Self Cite

View full text Add to dashboard Cite

A twenty-four-year-old mare, which had been examined seven years earlier for mitral valve regurgitation and mild left sided cardiomegaly, was presented with tachycardia, profuse sweating and muscle fasciculations. Blood examination revealed an increased packed cell volume, metabolic acidosis, hypocalcemia, hyperglycemia and increased cardiac troponin I concentration. ECG revealed ventricular premature beats and monomorphic ventricular tachycardia followed by polymorphic ventricular tachycardia with R-on-T phenomenon. The horse was treated immediately with hypertonic solution followed by isotonic solution and calcium, but the general condition deteriorated within forty-five minutes after arrival. The horse was euthanized due to poor prognosis. On necropsy, a pheochromocytoma of the left adrenal gland was found. Although this horse had undergone a cardiovascular examination seven and one year prior to the onset of the clinical signs, no indications for a neoplastic process or symptoms of a pheochromocytoma were found at that time. Early diagnosis of pheochromocytoma is based on catecholamine mediated cardiovascular effects, blood examination, blood pressure measurement, rectal palpation and rectal ultrasound of the adrenal gland. Based on a retrospective analysis of echocardiographic images and measurements, no predisposing factors were found. In this article, the importance of including pheochromocytoma as a differential diagnosis is highlighted, especially in older horses with acute polymorphic ventricular tachycardia, sweating, muscle tremors and signs of acute abdominal pain.

show abstract

Section: Case Historymentioning

confidence: 91%

Feochromocytoma bij een paard met polymorfe ventriculaire tachycardie

Dufourni¹,

Clercq²,

Vera³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

Self Cite

View full text Add to dashboard Cite

show abstract

“…Because of this, most of the research which studied plasma concentration of ANP and BNP in horses was performed using human kits (Nakagawa et al, 2019; Van Der Vekens et al, 2013). Evaluation of ANP concentration in horses using nonspecific kits demonstrated higher plasma concentration of ANP in horses with heart diseases and valvular regurgitation, especially mitral valve regurgitation, accompanied by the altered size of the left atrium and ventricle (Leroux et al, 2014; Trachsel et al, 2012, 2013, 2015; Van Der Vekens et al, 2016). However measurement of BNP in horses using kits available for another species does not show any significant differences between healthy horses and horses with cardiovascular diseases (Van Der Vekens, 2015).…”

Section: Introductionmentioning

confidence: 99%

Measurement of ANP, BNP and endothelin‐1 concentrations in jumping horses with heart valvular regurgitation and their correlation with the dimensions of heart structures

Chaleshtori

Dezfouli

Najizadeh

et al. 2022

Equine Veterinary Education

View full text Add to dashboard Cite

Summary Background Natriuretic peptides and endothelin‐1 are used as biochemical biomarkers for the diagnosis and prognosis of heart diseases. Objectives This study aimed to investigate plasma ANP, BNP and endothelin‐1 in jumping horses with various manifestations of heart valve regurgitation and their association with echocardiographic variables. Study design Clinical evaluations including cardiac auscultation were performed in 198 jumping horses, and 30 horses were chosen. Methods Sixteen jumping horses with murmurs of grade 3/6 to 5/6 having various degrees of heart valve regurgitation with the severity of insignificant to moderate on colour Doppler echocardiography were considered as the valvular regurgitation group (average age 9.75 ± 3.28 years and weight 427.43 ± 82.22 kg, and consisting of 10 mares, three stallions and three castrated male horses with breeds of 12 Thoroughbred and four crossbred). Fourteen healthy horses were chosen as the healthy group (average age 8.64 ± 2.44 years and weight 462.14 ± 77.42 kg, and consisting of nine mares, three stallions and two castrated males with breeds of 12 Thoroughbreds, and two crossbred). Blood samples were collected from the jugular vein, and plasma concentration of ANP, BNP and endothelin‐1 was determined using Sandwich ELISA by a horse‐specific kit. Then, the plasma concentration of mentioned peptides and echocardiographic variables were compared between the two groups. Results B‐type natriuretic peptide was significantly increased in horses with valve regurgitation compared to healthy horses, but increases in ANP and endothelin‐1 were insignificant. Also, in the valvular regurgitation group, horses with a pulmonic valve disorder had a significantly higher concentration of BNP and endothelin‐1 than healthy horses. Assessment of the relation between ANP, BNP and endothelin‐1 with echocardiographic variables showed a significant correlation between ANP and right ventricle length (RVL) and left ventricle width (LVW) in systole and endothelin‐1 with right ventricle width (RVW) and left ventricle width in systole, but BNP had no significant correlation. Conclusion and clinical importance According to the study results, it can be assumed that the measurement of these cardiac biomarkers can be helpful in the diagnosis of the jumping horse with cardiac valvular disorders (especially pulmonic valve regurgitation) and changes in the dimensions of the heart ventricle.

show abstract

“…NT-pro-BNP has become the most commonly used cardiac biomarkers due to its proven superiority compared to other biomarkers [37]. In horses, other peptides like atrial natriuretic peptide (ANP), N-terminal-pro-atrial natriuretic peptide (NT-pro-ANP) or the steroid hormone aldosterone have been investigated in horses with cardiac disease but failed to be established [11, 36].…”

mentioning

confidence: 99%

Measurement of plasma endothelin-1 concentration in healthy horses and horses with cardiac disease during rest and after exercise

Gehlen

Shety

El-Zahar

et al. 2019

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

Cardiac biomarkers are important tools for monitoring disease progress and can monitor progression of therapy. Endothelin-1 (ET-1) has been studied for its use as a cardiac biomarker in human and small animal medicine while in horses with cardiac disease it has not been evaluated yet. The objective of the present study was to determine the concentration of plasma ET-1 in healthy horses and compare it with ET-1 concentration in horses with cardiac disease during rest and after exercise. Fifty four horses admitted to the Equine Clinic of Free University of Berlin were used in the present study, of which 15 horses were clinically healthy with no evidence of cardiac disease (Group 1), 22 horses suffered from cardiac disease with normal heart dimensions (Group 2) and 17 horses with cardiac disease and enlarged heart diameters (Group 3). Clinical examination, electrocardiography and echocardiography were performed. Endothelin-1 concentration was determined using ET-1 ELISA kit. The concentration of plasma ET-1 was significantly increased in horses with cardiac disease and normal cardiac dimensions (Group 2) and in horses with cardiac disease and enlargement of the left atrium (Group 3) compared to its concentration in clinically healthy horses (Group 1). In addition, the concentration of plasma ET-1 after exercise was significantly increased in diseased horses compared to its concentration at rest. Detection of ET-1 plasma concentration in horses at rest may be useful for detecting horses with changes in left atrial cardiac dimensions.

show abstract

Atrial natriuretic peptide vs.N‐terminal‐pro‐atrial natriuretic peptide for the detection of left atrial dilatation in horses

Cited by 10 publications

References 44 publications

Feochromocytoma bij een paard met polymorfe ventriculaire tachycardie

Feochromocytoma bij een paard met polymorfe ventriculaire tachycardie

Measurement of ANP, BNP and endothelin‐1 concentrations in jumping horses with heart valvular regurgitation and their correlation with the dimensions of heart structures

Measurement of plasma endothelin-1 concentration in healthy horses and horses with cardiac disease during rest and after exercise

Contact Info

Product

Resources

About