RETRACTED: Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells

Abstract

SignificancePostoperative cancer recurrence is a major problem following curative cancer surgery. Perioperative systemic inflammation induces the adhesion of circulating tumor cells released from the primary tumor to the vascular endothelium of distant organs, which is the first step in hematogenous metastasis. We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. Here, we demonstrate that cancer recurrence after lung cancer surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). We show that ANP prevents cancer metastasis by suppressing the inflammatory reaction of endothelial cells, thereby inhibiting cancer cell adhesion to vascular endothelial cells.

Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

“…A recent study reported that atrial natriuretic peptide (ANP), a polypeptide hormone that induces cGMP up-regulation through the natriuretic peptide receptor, drastically suppressed the recurrence of lung cancer after curative surgery (45). In this clinical study, the 2-year relapse-free survival rate in the propensity score-matched analysis was also significantly greater in ANP-treated patients than in control patients (91 versus 67%, p ϭ 0.0013).…”

“…Unwilling TLR4 signaling-induced low grade inflammation are widely involved in several types of disease including obesityinduced inflammation (13), atherogenesis (47), Alzheimer's disease (50), tumor metastasis (45), and the adverse effect of opioids (37). However, the effective countermeasures for suppressing TLR4 signaling is not established.…”

Transcriptional Analysis of Endothelial Cell Alternation Induced by Atrial Natriuretic Polypeptide in Human Umbilical Vein Endothelial Cells

“…5,6) To expand the adaptation of ANP for cancer therapy, however, the detailed mechanism of action of ANP should be further investigated. In this study, we explored the effects of ANP on HUVEC cells at different time points, and found that the molecular mechanism underlying the impacts of ANP on endothelial cells may change over time.…”

“…Gene expression profile data: To explore the molecular mechanisms of ANP in vascular endothelial cells, the gene expression data GSE56976 6 for HUVEC was downloaded from NCBI GEO (Gene Expression Omnibus; http://www. ncbi.nlm.nih.gov/geo) as TXT files.…”

“…Nojiri, et al have reported that the expression of E-selectin, a critical component in hematogenous metastasis, was suppressed by ANP in human umbilical vein endothelial cells (HU-VEC). 6) Serafino, et al reported that ANP regulates cellular acidification and the Wnt/β-catenin signaling cascade to produce anti-proliferative effects in colorectal cancer cells. 7) Therefore, ANP could be used in clinical practice for cancer therapy.…”