Atrial natriuretic peptide/natriuretic peptide receptor A (ANP/NPRA) signaling pathway: A potential therapeutic target for allergic asthma

Ma, Liwei; Xiang, Xudong

doi:10.1016/j.mehy.2011.07.048

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…There is evidence of many other actions resulting from the stimulation of these receptors; namely decreased cell proliferation [17], apoptosis [7,18], decreased cardiac fibrosis [19], as well as effects on cardiovascular remodelling. NPR-A stimulation may even play a role in immune dysfunction and airway inflammation in conditions such as allergic asthma [20]. NPR-B has vasodilator effects [21], and is also associated with cell proliferation [19] and bone growth [22].…”

Section: Receptor Physiological Functionsmentioning

confidence: 99%

Advances in the Mechanism of Action of Natriuretic Peptides at a Cellular Level

Mannu

Bhalerao

2015

BJMMR

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Background: Natriuretic peptides have a vast array of different actions at numerous sites throughout the human body. There have been rapid advances in understanding their mechanism of action in recent years and this review aimed to collate all available information on this field in order to present the current evidence-base. Method: A two-step process utilising a Medline/PubMed systematic search was conducted. The initial search was undertaken using elementary phrases. The search produced over 4000 published papers on the topic of the mechanisms of action of natriuretic peptides. The resultant abstracts were analysed and appropriate papers were selected. The secondary search was performed by (1) using the reference lists of the chosen articles and (2) by using PubMed weblink for related articles. The studies were selected if they were in English language published in the past 30 years and included the appropriate topics. All of the reports regarding the intracellular and pharmacological mechanisms of action of natriuretic peptides were selected. Conclusions: This review has collected all information on the recent advances in our understanding of the intracellular pathways that allow these peptides to bring about natriuresis, vasodilatation and their many other effects. Although offering significant pharmacological potential, Review Articlethis field remains poorly understood and there is a need for more research using newer research techniques.

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Section: Receptor Physiological Functionsmentioning

confidence: 99%

Advances in the Mechanism of Action of Natriuretic Peptides at a Cellular Level

Mannu

Bhalerao

2015

BJMMR

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“…Atrial natriuretic peptide (ANP), brain or B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are three kinds of NPs [15,16]. Interestingly, it should be noted that the indicative and therapeutic efficacy of NPs are greatly dependent on the natriuretic peptide receptors (NPRs) in individuals [16,17].…”

Section: Classify Cardiovascular Patients Based On the Polymorphisms mentioning

confidence: 99%

“…Interestingly, it should be noted that the indicative and therapeutic efficacy of NPs are greatly dependent on the natriuretic peptide receptors (NPRs) in individuals [16,17]. Generally, the natriuretic peptide receptor A and B (NPRA and NPRB) are responsible for receiving the NP signalings, while the natriuretic peptide receptor C (NPRC) is responsible for the clearance of NPs [13,[18][19][20].…”

Section: Classify Cardiovascular Patients Based On the Polymorphisms mentioning

confidence: 99%

Clinical Benefits of the Classification of Cardiovascular Patients based on the Polymorphisms of Natriuretic Peptide Receptor Genes

Guo¹

2014

J Mol Biomark Diagn

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Natriuretic peptides (NPs NP) are supposed to be important biomarkers as well as therapeutic medicines for cardiovascular diseases, however, there are still some controversies blocking the clinical application of NPs. Especially, natriuretic peptide receptors (NPRs) greatly interfere with the indicative efficiency, therapeutic effectiveness, clinical dosage, and medication time of NPs. Herein, we propose that the classification of cardiovascular patients will effectively promote the clinical utilization of NPs as either biomarkers or medicines. Generally, NPs bind to natriuretic peptide receptor A and B (NPRA and NPRB) to activate cellular signalings, but natriuretic peptide receptor C (NPRC) is mainly responsible for the clearance of NPs. So, it is expected that high NPs-sensitivity group includes individuals carrying the alleles that result in higher activity of NPRA and NPRB and lower activity of NPRC, while low NPs-sensitivity group is the opposite. Theoretically, the classification will improve the diagnostic accuracy of NPs for cardiovascular patients, and personalized administration of NPs-related medicines will benefit more individuals in order to achieve both of the maximum therapeutic efficacy and the minimum side effects.

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Membrane Receptors and Signal Transduction Pathway

Wardhan

Mudgal

2017

Textbook of Membrane Biology

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Atrial natriuretic peptide/natriuretic peptide receptor A (ANP/NPRA) signaling pathway: A potential therapeutic target for allergic asthma

Cited by 8 publications

References 17 publications

Advances in the Mechanism of Action of Natriuretic Peptides at a Cellular Level

Advances in the Mechanism of Action of Natriuretic Peptides at a Cellular Level

Clinical Benefits of the Classification of Cardiovascular Patients based on the Polymorphisms of Natriuretic Peptide Receptor Genes

Membrane Receptors and Signal Transduction Pathway

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