Atrial natriuretic peptide in relation to physical exercise

Bollerslev, Jens; Svanegård, J.; Blaabjerg, Ole; Pindborg, T

doi:10.1080/00365518709168929

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Plasma atrial natriuretic peptide rose during exercise. 2 The term "athelete's heart" was introduced by Henschen in 1899.' In this condition all the chambers of the heart are dilated and there is hypertrophy of the myocardium due to physical training.4"…”

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Physiological hypertrophy of the heart and atrial natriuretic peptide during rest and exercise.

Svanegaard

Angelo-Nielsen

Hansen

1989

Heart

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Atrial natriuretic peptide is a circulating hormone secreted by the atrial myocytes of the heart. It is released in response to increased atrial pressure,' which is generally equal to increased stretch and dilatation of the atrial wall. Plasma atrial natriuretic peptide rose during exercise.2The term "athelete's heart" was introduced byHenschen in 1899.' In this condition all the chambers of the heart are dilated and there is hypertrophy of the myocardium due to physical training.4"The purpose of this study was to determine whether the hypertrophy and dilatation of the heart seen in well trained persons influence the plasma concentration of atrial natriuretic peptide at rest or during exercise.Requests for reprints to Dr Jens Svanegaard, Departnent of Cardiology, Odense University Hospital, Odense C, Denmark DK-5000.Accepteq for publication 27 June 1989 Patients and methods We studied six male footballers who trained strenuously and six normally active healthy matched controls (aged 21-30 years). None was taking medical treatment. The controls did not participate in any form of athletics for more than four hours a week. They all gave informed consent and the study was approved by the local ethics commnittee.All of the investigations were undertaken between 3 pm and 7 pm. Echocardiography, with cross sectional and M mode recordings, was performed with a Hewlett Packard 77020A ultrasonograph and a 3-5 MHz transducer on men in the supine position.All the M mode measurements originated from three or four consecutive cardiac cycles graded according to the system of the American Society of Echocardiography.

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confidence: 99%

Physiological hypertrophy of the heart and atrial natriuretic peptide during rest and exercise.

Svanegaard

Angelo-Nielsen

Hansen

1989

Heart

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“…As a strong stimulation factor, exercise may increase plasma ANP levels, which can be observed in normal people, sporteman and experimental animals. Bollerslev et al (1987) measured plasma ANP levels after healthy young subjects were exercised on a bicycle ergometer until exhaustion, and found that the plasma ANP levels increased significantly and returned to normal after 45 min. Toft et al (1990) reported that 11 elite mid and long‐distance runners had a prominent increase in plasma ANP levels immediately after a 5‐km race, in spite of a high maximal cardiac output.…”

Section: Discussionmentioning

confidence: 99%

Alterations of atrial natriuretic peptide in cardiomyocytes and plasma of rats after different intensity exercise

2007

Scandinavian Med Sci Sports

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To characterize the effect of long-term exercise training at different intensities on endocrine structure and function of the heart, plasma atrial natriuretic peptide (ANP) levels, expression of ANP in cardiomyocytes, and ultrastructure of cardiomyocytes were examined by radioimmunoassay, immunohistochemistry and transmission electron microscopy in Sprague-Dawley rats trained on a treadmill at different intensities for 8 weeks. The plasma ANP increased gradually with increasing exercise intensity. The immunoreactivity of ANP in cardiomyocytes increased in the moderate- and high-intensity exercise group and decreased in the exhaustive exercise group. The ANP electron-dense granules and the quantity and volume of mitochondria increased in moderate and high-intensity exercise group. The ANP electron dense granules decreased and the mitochondria tumefied in the exhaustive exercise group. The changes of plasma ANP have a tendency of increasing gradually with increase in exercise intensity. Moderate and high-intensity exercise increases ANP synthesis and storage in cardiomyocytes and induces adaptive changes in the ultrastructure of cardiomyocytes. The decrease of ANP immunoreactivity in cardiomyocytes after exhaustive exercise is probably the result of massive depletion and induces damaging changes in the ultrastructure of cardiomyocytes.

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“…In healthy volunteers, maximal ANF response appears to correspond to the end of a period of vigorous exercise (Bollerslev et al, 1987;Fyhrquist et al, 1987;Saito et al, 1987;Somers et al, 1986). Recovery to pre-exercise resting ANF concentrations may take over 15 min (Bollerslev et al, 1987). Our aged control subjects produced a 47% increment in ANF above baseline in response to the first-symptom limited exercise test.…”

Section: Discussionmentioning

confidence: 99%

Effect of captopril on functional, physiological and biochemical outcome criteria in aged heart failure patients.

O'neill

Charlett

Dobbs

et al. 1992

Brit J Clinical Pharma

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1 Captopril was evaluated as an adjuvant to diuretic and digoxin therapy in heart failure in old age, using walking ability, minute ventilation and oxygen consumption and plasma atrial natriuretic factor (ANF) (6) years, and the increase on exercise, seen in the controls (P < 0.01), was absent. In the patients the resting plasma ANF concentration was significantly affected by treatment (P = 0.03), being less on both AP, 245 (9), and AA, 214 (9) than on PP, 264 (10) pmol 1-1 (P = 0.02 and 0.03, respectively).7 Baseline serum ACE activity was induced on active treatment. The change in ACE activity at 3 h post an active dose was significantly greater on AP than AA (P = 0.005).The increased sensitivity to inhibition during once daily administration was reflected in mean arterial pressure. The pre-dose standing pressure was less on AP than on PP (P < 0.05), and the change in postural fall (pre-dose minus 2 h post), was greater (P = 0.004), but AA and PP were similar in these respects. 8 A linear model, taking account of structure of the study, change in ACE activity and standing blood pressure, showed a significant effect of treatment on distance walked in the SWT (P = 0.04), enhanced the overall effect on resting ANF (P = 0.02), but failed to reveal any effect on the ventilation to oxygen consumption ratio. 9 Putative adverse effects caused withdrawal in 6/26 patients in the pre-trial period,

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Atrial natriuretic peptide in relation to physical exercise

Cited by 11 publications

References 14 publications

Physiological hypertrophy of the heart and atrial natriuretic peptide during rest and exercise.

Physiological hypertrophy of the heart and atrial natriuretic peptide during rest and exercise.

Alterations of atrial natriuretic peptide in cardiomyocytes and plasma of rats after different intensity exercise

Effect of captopril on functional, physiological and biochemical outcome criteria in aged heart failure patients.

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